131 Hepatic Stellate Cell Activation: An Important Contributor to Persistent Hepatic Resistance in Small-for-Size Livers After Extended Partial Hepatectomy in the Rat

Modeling the Impact of Partial Hepatectomy on the Hepatic Hemodynamics Using a Rat Model

“…A subset of the boundary conditions was defined by using results of in vivo rat hepatectomy experiments by Fan et al according to the surgical procedure as described in [20] and [37]. During these experiments, the PV pressure P PV and total PV flow Q PV,total as well as the HA flow Q HA,total were measured before and after 70%, 80%, and 90% hepatectomy (see Table II).…”

“…Both the pressure-and flow-driven models were initially solved and, subsequently, tuned to be in accordance with the pressure and flow measurements performed by Fan et al [20] for a healthy total rat liver (see Table II). …”

“…Since results of the initial model showed some differences between model-predicted hemodynamics and those measured by Fan et al [20] before hepatectomy, the exponential trend lines with the highest degree of uncertainty (mainly due to the finite spatial scanning resolution) were adjusted as in [31] in order to improve the physiological accuracy of the model. This resulted in the a and b values of Table III.…”

“…For instance, Fan et al [20] and Vanheule et al [37] resected the LML, RML, LLL, IRL, AC, and PC to do a 90% resection, while in contrast, Dahmen et al [14] removed the LML, RML, LLL, SRL, and IRL (see Fig. 2).…”

“…2). In this study, the resection method of Fan et al [20] was applied virtually to the 3-D reconstructions of the vascular trees. Consequently, a resection of 70% corresponds with the removal of the LML, RML, and LLL (see Fig.…”