131I-labeled PEG and folic acid co-functionalized graphene quantum dots for tumor-targeted imaging

Wang, Yunhan; Song, Huacan; Wang, Guanquan; Xia, Yang; Wang, Jing; Wei, Hongyuan

doi:10.1007/s10967-019-06434-8

Cited by 24 publications

(10 citation statements)

References 20 publications

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“…Hence, the intrinsic fluorescence and superparamagnetic property make MGQDs a promising contrast agent for dual-modal Fl/OCT imaging. Recently, using 131 I-labeled FA-GQDs, Wei's group demonstrated targeted single-photon emission computed tomography (SPECT) imaging in vivo (Wang et al, 2019c). Owing to FA targeting, the 131 I-labeled FA-GQDs were preferentially uptaken by the HeLA cells, while after i.v.…”

Section: Dual-modal Imagingmentioning

confidence: 99%

Recent Advances on Graphene Quantum Dots for Bioimaging Applications

et al. 2020

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Being a zero-dimensional (0D) nanomaterial of the carbon family, graphene quantum dots (GQDs) showed promising biomedical applications owing to their ultra-small size, non-toxicity, biocompatibility, excellent photo stability, tunable fluorescence, and water solubility, etc., thus capturing a considerable attention in biomedical field. This review summarizes the recent advances made in the research field of GQDs and place special emphasis on their bioimaging applications. We briefly introduce the synthesis strategies of GQDs, including top-down and bottom-up strategies. The bioimaging applications of GQDs are also discussed in detail, including optical [fluorescence (FL)], two-photon FL, magnetic resonance imaging (MRI), and dual-modal imaging. In the end, the challenges and future prospects to advance the clinical bioimaging applications of GQDs have also been addressed.

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Section: Dual-modal Imagingmentioning

confidence: 99%

Recent Advances on Graphene Quantum Dots for Bioimaging Applications

et al. 2020

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“…In terms of imaging, a study from Wang et al endorsed the idea once they synthesized GQDs co-functionalized with PEG and FA to improve the capacity for biocompatibility and to target tumors, respectively [ 257 ]. Subsequently, the nanocomposites were radiolabeled with I-131 to assess biological behavior.…”

Section: Reviewmentioning

confidence: 99%

Graphene and its derivatives: understanding the main chemical and medicinal chemistry roles for biomedical applications

et al. 2021

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Graphic abstract Over the past few years, there has been a growing potential use of graphene and its derivatives in several biomedical areas, such as drug delivery systems, biosensors, and imaging systems, especially for having excellent optical, electronic, thermal, and mechanical properties. Therefore, nanomaterials in the graphene family have shown promising results in several areas of science. The different physicochemical properties of graphene and its derivatives guide its biocompatibility and toxicity. Hence, further studies to explain the interactions of these nanomaterials with biological systems are fundamental. This review has shown the applicability of the graphene family in several biomedical modalities, with particular attention for cancer therapy and diagnosis, as a potent theranostic. This ability is derivative from the considerable number of forms that the graphene family can assume. The graphene-based materials biodistribution profile, clearance, toxicity, and cytotoxicity, interacting with biological systems, are discussed here, focusing on its synthesis methodology, physicochemical properties, and production quality. Despite the growing increase in the bioavailability and toxicity studies of graphene and its derivatives, there is still much to be unveiled to develop safe and effective formulations.

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“…GQDs functionalized by PEG and FA were synthesized and labelled with 131 I for biological behaviour evaluation, showing low cytotoxicity and high biocompatibility. [ 105 ] Tumour‐bearing mice were intravenously injected via the tail, and by using SPECT imaging, the uptake of 131 I‐GQDs‐PEG‐FA at tumour tissues can be undoubtedly detected. This result suggests that 131 I‐GQDs‐PEG‐FA can be used as a probe for clinical application.…”

Section: Tumour Diagnosis Of Cdsmentioning

confidence: 99%

Applications of carbon dots on tumour theranostics

et al. 2021

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Carbon dots (CDs) have been extensively investigated as prime candidates for developing tumour theranostic platform due to their tunable fluorescence emission and excitation, good photostability, high water solubility and biocompatibility. Herein, we will update the recent research and latest development on the preparation, hydrophilicity, biotoxicity and optical property of CDs, as well as their applications in multimodal bioimaging and anticancer drug delivery. We will mainly highlight their applications in in vivo imaging and tumour‐targeted theranostics with a special emphasis on large amino acid‐mimicking carbon quantum dots‐based tumour theranostics through a large neutral amino acid transporter 1 (LAT1)‐mediated targeted strategy. Finally, we will also discuss the current status, key challenges and future directions of CDs in tumour theranostics. We expect that this review will summarize recent advances to inspire more researches on CDs for biomedical and clinical applications in the near future.

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131I-labeled PEG and folic acid co-functionalized graphene quantum dots for tumor-targeted imaging

Cited by 24 publications

References 20 publications

Recent Advances on Graphene Quantum Dots for Bioimaging Applications

Recent Advances on Graphene Quantum Dots for Bioimaging Applications

Graphene and its derivatives: understanding the main chemical and medicinal chemistry roles for biomedical applications

Applications of carbon dots on tumour theranostics

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