131I treatment in Differentiated Thyroid Cancer and End-Stage Renal Disease

Martínez-Ortega, Antonio Jesús; Vázquez, Ricardo; Cuenca, J.I. Cuenca; Brocca, María Asunción Martínez; Castilla, J.D. López; Martı́nez, J.; González, Elena Navarro

doi:10.1016/j.remn.2015.05.008

Cited by 2 publications

(3 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A reduction of the empirical I 131 dose should be considered in CKD patients, achieving a 50% in hemodialysis patients that should be treated 48 h before and after the administration of the radioisotope [ 32 , 33 ]. A similar dose reduction is also required in peritoneal dialysis patients [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

“…A 50% I 131 dose reduction has been suggested in patients on haemodialysis. It is recommended that each I 131 infusion should be preceded and followed at 48 h by a haemodialysis session [ 32 , 33 ]. In patients on peritoneal dialysis, the clearance of I 131 was found to be less than 20% compared to normal renal function patients [ 34 ], suggesting a proportional dose reduction even in this patient typology.…”

Section: I 131 Radiotherapymentioning

confidence: 99%

See 1 more Smart Citation

Impact of Thyroid Cancer Treatment on Renal Function: A Relevant Issue to Be Addressed

Paola

Capasso

et al. 2023

JPM

View full text Add to dashboard Cite

Thyroid cancers require complex and heterogeneous therapies with different impacts on renal function. In our systematic literature review, we analyzed several aspects: renal function assessment, the impact of radiotherapy and thyroid surgery on kidney functioning, and mechanisms of nephrotoxicity of different chemotherapy, targeted and immunologic drugs. Our study revealed that the renal impact of thyroid cancer therapy can be a limiting factor in all radiotherapy, surgery, and pharmacological approaches. It is advisable to conduct a careful nephrological follow-up imposing the application of body surface based estimated Glomerular Filtration Rate (eGFR) formulas for the purpose of an early diagnosis and treatment of renal failure, guaranteeing the therapy continuation to thyroid cancer patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: I 131 Radiotherapymentioning

confidence: 99%

Impact of Thyroid Cancer Treatment on Renal Function: A Relevant Issue to Be Addressed

Paola

Capasso

et al. 2023

JPM

View full text Add to dashboard Cite

show abstract

“…Enlargement of cervical lymph nodes is the first sign in about 10 % of cases. Despite progress in the treatment of DTC recently, including surgery, radioactive iodine therapy and endocrine therapy using levothyroxine, the overall survival rate of patients with DTC is still far from satisfactory [11] . I 131 therapy has become the preferred clinical treatment method for DTC, which can well improve the prognosis of disease.…”

Section: Discussionmentioning

confidence: 99%

Effects of Hypothyroidism on Quality of Life of Differentiated Thyroid Carcinoma Patients undergoing Postoperative Iodine-131 Therapy

Que¹,

Fan²,

Wang³

et al. 2021

ijps

View full text Add to dashboard Cite

To evaluate the effects of hypothyroidism on the quality of life of differentiated thyroid carcinoma patients undergoing postoperative iodine-131 (I 131 ) therapy. A total of 140 thyroid carcinoma inpatients treated in our hospital from January 2016 to June 2017 were collected. All patients were treated with postoperative I 131 therapy, and followed up for 3 years. The effect of I 131 therapy on hypothyroidism was observed from the perspectives of gender, age, course of disease and I 131 . On this basis, multivariate logistic regression analysis was performed to screen the influencing factors for hypothyroidism in differentiated thyroid carcinoma patients undergoing postoperative I 131 therapy, and the predictive model was established. Quality of life of patients was compared before and after I 131 therapy, and the correlation between thyroid function indices and quality of life was further analyzed. The predictive value of I 131 therapy after differentiated thyroid carcinoma surgery for the levels of thyroid function indices and quality of life was evaluated using receiver operating characteristic curve. A total of 140 patients undergoing I 131 therapy after differentiated thyroid carcinoma surgery were enrolled. It was found through follow-up that the incidence rate of hypothyroidism was 35.00 % (49/140). The incidence of hypothyroidism after I 131 therapy was related to the thyroid quality, course of disease, cumulative dose of I 131 and operation method (p<0.01), but not related with gender, age or pathological type (p>0.05). The forest plot of multivariate logistic regression analysis results showed that thyroid quality, course of disease, I 131 dose and operation method were independent risk factors for hypothyroidism after postoperative I 131 therapy. Compared with before I 131 therapy, each index of quality of life was significantly increased in differentiated thyroid carcinoma patients after postoperative I 131 therapy (p<0.05). The results of correlation analysis revealed that some indices of quality of life (physical function, bodily pain, social function and mental health) were all positively correlated with thyroid function indices total triiodothyronine, free triiodothyronine, free thyroxine, total thyroxine and thyroid stimulating hormone (p<0.05 or p<0.01). Other indices of quality of life (role physical, general health, vitality and role emotional) had no significant correlations with triiodothyronine, free triiodothyronine, free thyroxine, total thyroxine or thyroid stimulating hormone (p>0.05). The area under receiver operating characteristic curve of thyroid stimulating hormone level in differentiated thyroid carcinoma patients was 0.819 (95 % CI: 0.744-0.893), and the optimal cutoff value was 0.63 mU/L. The cutoff value of I 131 dose was 7.35 GBq, and the area under receiver operating characteristic curve was 0.726 (95 % CI: 0.623-0.830). Hypothyroidism in differentiated thyroid carcinoma patients undergoing postoperative I 131 therapy has a significant impact on quality of life. There are co...

show abstract

131I treatment in Differentiated Thyroid Cancer and End-Stage Renal Disease

Cited by 2 publications

References 31 publications

Impact of Thyroid Cancer Treatment on Renal Function: A Relevant Issue to Be Addressed

Impact of Thyroid Cancer Treatment on Renal Function: A Relevant Issue to Be Addressed

Effects of Hypothyroidism on Quality of Life of Differentiated Thyroid Carcinoma Patients undergoing Postoperative Iodine-131 Therapy

Contact Info

Product

Resources

About