1340 Non-invasive evaluation of skin biophysical properties of striae distensae

Abstract

Striae distensae are skin lesions which occur in rapid tissue expansion such as pregnancy, puberty, obesity as well as in medical use of corticosteroids. They appear as parallel inflammatory streaks aligned perpendicular to the direction of skin tension. In early stage, striae distensae are raised and erythematous (rubra), but they develop into chronic phase of hypopigmented, atrophic scars (alba). Measurements of striae distensae are essential to research the aetiological mechanism or to evaluate the clinical efficacy of treatments. The objective of this study was to investigate skin biophysical properties of striae distensae in vivo. Volunteers with striae rubra or alba on different locations of the body participated. Noninvasive measurements including skin surface structure, skin lightness, and hydration were conducted on striae distensae and compared to adjacent normal skin. As a result, striae alba had a wrinkled, atrophied structure, and the wrinkle depth and depressed volume were higher than normal skin. Striae rubra were slightly raised, and the volume of elevation could be measured quantitatively. As for the blob pattern of skin surface, striae distensae were more anisotropic and directional, and showed more irregular polygonal pattern of each segmented unit than normal skin. The average area of each blob was higher and the number of blob per unit area was less than normal skin. In addition, striae alba showed increased lightness (L*) and decreased redness (a*), whereas striae rubra had decreased L* and increased a* when compared to normal skin. Difference in skin hydration was not detected between striae distensae and adjacent skin. In conclusion, we measured the various skin biophysical properties of striae distensae including rubra and alba, and found out significant differences in skin color and various surface structures when compared to the adjacent normal skin. These features were proved to be reliable evaluation parameters for striae distensae severity. 1341 CXCL12 enhances migration of Multilineage-differentiating stress enduring cells and induces Wnt3a to maintains cell plasticity of fibroblasts

A Narrative Review of Current Striae Treatments

“…Stretch marks are caused by rapid tissue expansion, a process that can occur during pregnancy, puberty, obesity, and in diseases whose treatment requires the use of corticosteroids [ 16 ]. The most common risk factors for developing stretch marks include young age, skin phototype, maternal and family history of stretch marks, higher pre-pregnancy, and pre-labour weight [ 14 ].…”

“…Initially, striae present erythematous lesions ( rubrae ), but, in the chronic phase, they develop into hypopigmented atrophic scars ( albae ) [ 16 ]. Kim, M., Kim, S., and Jung, Y., et al decided to evaluate the biophysical properties of striae distensae , rubrae , and albae to understand the etiological mechanism and evaluate the efficacy of treatments, considering skin surface structure, skin lightness, and hydration, and found significant differences in the colour of the skin and in various surface structures compared to adjacent normal skin [ 16 ]. Regarding skin surface patches, striae were more anisotropic and directional, with a more irregular polygonal pattern of each segmented unit compared to the normal skin [ 16 ].…”

“…Kim, M., Kim, S., and Jung, Y., et al decided to evaluate the biophysical properties of striae distensae , rubrae , and albae to understand the etiological mechanism and evaluate the efficacy of treatments, considering skin surface structure, skin lightness, and hydration, and found significant differences in the colour of the skin and in various surface structures compared to adjacent normal skin [ 16 ]. Regarding skin surface patches, striae were more anisotropic and directional, with a more irregular polygonal pattern of each segmented unit compared to the normal skin [ 16 ]. Regarding the results of striae albae, they showed a wrinkled and atrophied structure, deeper and more voluminous than normal skin [ 16 ].…”

“…Regarding skin surface patches, striae were more anisotropic and directional, with a more irregular polygonal pattern of each segmented unit compared to the normal skin [ 16 ]. Regarding the results of striae albae, they showed a wrinkled and atrophied structure, deeper and more voluminous than normal skin [ 16 ]. In addition, while the striae albae showed more brightness and less redness, the striae rubra did not [ 16 ].…”

“…Regarding the results of striae albae, they showed a wrinkled and atrophied structure, deeper and more voluminous than normal skin [ 16 ]. In addition, while the striae albae showed more brightness and less redness, the striae rubra did not [ 16 ].…”