1341 Performance of Non-Invasive Liver Fibrosis Tests in Predicting Death Rate in Patients With Alcoholic Cirrhosis

Bertrais, Sandrine; Couffon, Caroline; Rondeau, L; Favre, M; Oberti, Frédéric; Fouchard-Hubert, I.; Dib, Nina; Boursier, Jérôme; Calès, Paul

doi:10.1016/s0168-8278(12)61352-x

Cited by 1 publication

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“…Four other studies 23–26 reported AUROCs for predicting mortality or LREs using continuous liver stiffness measurements, with AUROCs of 0.65, 0.675, 0.7, and 0.76. Two of these four studies 23,26 also reported liver stiffness thresholds, with one using a threshold of 25 kPa, finding a significant difference in mean incidence of LRE of 4.5% in the < 25‐kPa cohort as compared with 15.5% in the > 25‐kPa cohort 26 .…”

Section: Resultsmentioning

confidence: 99%

Systematic review: Investigating the prognostic performance of four non‐invasive tests in alcohol‐related liver disease

Rhodes

Trembling

Panovska‐Griffiths

et al. 2021

J of Gastro and Hepatol

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Background and Aim Mortality of alcohol‐related liver disease (ArLD) is increasing, and liver fibrosis stage is the best mortality predictor. Non‐invasive tests (NITs) are increasingly used to detect fibrosis, but their value as prognostic tests in chronic liver disease, and in particular in ArLD, is less well recognized. We aimed to describe the prognostic performance of four widely used NITs (Fibrosis 4 test [FIB4], Enhanced Liver Fibrosis [ELF] test, FibroScan, and FibroTest) in ArLD. Methods Applying systematic review methodology, we searched four databases from inception to May 2020. Inclusion/exclusion criteria were applied to search using Medical Subject Heading terms and keywords. The first and second reviewers independently screened results, extracted data, and performed risk‐of‐bias assessment using Quality in Prognosis Studies tool. Results Searches produced 25 088 articles. After initial screening, 1020 articles were reviewed independently by both reviewers. Eleven articles remained after screening for eligibility: one on ELF, four on FibroScan, four on FIB4, one on FIB4 + FibroScan, and one on FibroTest + FIB4. Area under the receiver operating characteristic curves for outcome prediction ranged from 0.65 to 0.76 for FibroScan, 0.64 to 0.83 for FIB4, 0.69 to 0.79 for FibroTest, and 0.72 to 0.85 for ELF. Studies scored low–moderate risk of bias for most domains but high risk in confounding/statistical reporting domains. The results were heterogeneous for outcomes and reporting, making pooling of data unfeasible. Conclusions This systematic review returned 11 papers, six of which were conference abstracts and one unpublished manuscript. While the heterogeneity of studies precluded direct comparisons of NITs, each NIT performed well in individual studies in predicting prognosis in ArLD (area under the receiver operating characteristic curves >0.7 in each NIT category) and may add value to prognostication in clinical practice.

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Section: Resultsmentioning

confidence: 99%