(138) Running Out of Options: A Case of DRESS with Possible Neosensitization to Lurasidone in an Acutely Manic, Psychotic, and Catatonic Patient

Bryant, Cody A.; Cinibulk, Margaret; Manchee, Charles; Cho, Stephanie H.

doi:10.1016/j.jaclp.2022.10.140

Cited by 2 publications

(1 citation statement)

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“…Study showed a case of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome with possible neosensitization to lurasidone in a patient with BD. The patient was developed DRESS syndrome after risperidone and valproate treatment, and subsequent rash recurrence when lurasidone trial [ 32 ]. Although the cutaneous eruption has also been described as a maculopapular or erythematous rash in case reports of DRESS syndrome [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Rash caused by lurasidone in old chinese patient with bipolar disorder: case-based review

Yang,

Hu,

Zheng

et al. 2024

BMC Psychiatry

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Background Rash is one of common adverse drug reaction and which have been reported in typical and atypical antipsychotics. Reports of lurasidone induced skin reactions are sparse. In this study, we report a case of rash caused by lurasidone. Case presentation A 63-year-old man with bipolar disorder (BD) who is treated by lurasidone. However, the patient presents a rash all over after lurasidone dose increasing from 40 mg/day to 60 mg/day. With the diagnosis of drug induced rash, lurasidone was discontinued, and the rash complete disappears within 2 weeks. In addition, all case reports about antipsychotics associated rash were reviewed by searching English and Chinese database including Pubmed, Embase, Cochrane Library, CNKI and Wanfang database. A total of 139 articles contained 172 patients were included in our study. The literature review and our case suggest that the cutaneous adverse events caused by antipsychotic drugs should not be ignored, particularly for the patient who was first use or at dose increasing of antipsychotic. Conclusions In conclusion, we report a case of lurasidone related rash and review rash caused by antipsychotics. Psychiatrists should be alert to the possibility of the rash caused by antipsychotics, especially the patient was first use of antipsychotics or the antipsychotic dose was increasing.

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Section: Discussionmentioning

confidence: 99%