1384P Prognostic factors for survival in patients with metastatic lung adenocarcinoma: Analysis of the SEER database

Abstract

characteristics and treatment. All cases were re-reviewed by an expert adjudicator. Accuracy and concordance between automated and manual methods are reported. Results: Automated extraction required significantly less time (<72 hours) than manual extraction (225 person-hours). Collection of demographic data (age, sex, diagnosis) was highly accurate and concordant with both methods, (96-100%). Accuracy and concordance were lower for unstructured data elements in EHR, such as ECOG performance status, date of stage IV diagnosis and smoking status (automated accuracy: 94%, 93%, 88% respectively; manual accuracy: 83%, 78% and 94%). Detection of biomarker testing was highly accurate and concordant (96-98%), although detection of final results was more variable (accuracy 84-100%, concordance 84-99%). Automated extraction identified metastatic sites more accurately than manual (concordance 70-99%), with the exception of lymph node metastasis (automated 66%, manual 92%, concordance 58%), due to use of analogous terms in radiology reports not included in the gold standard definition. Concurrent medications (86-100%) and comorbid conditions (96-100%), were reported with high accuracy and concordance. Treatment details were also accurately captured with both methods (84-100%) and highly concordant (83-99%). Conclusions: Automated data abstraction from unstructured EHR is highly accurate and faster than manual abstraction. Key challenges include poorly structured EHR and use of analogous terms beyond the gold standard definition. Legal entity responsible for the study: The authors.

The nomogram for the prediction of overall survival in patients with metastatic lung adenocarcinoma undergoing primary site surgery: A retrospective population-based study

“…NAKAZAWA et al results suggested that existing liver and bone metastasis adversely affected the outcome of the disease (28). The presence of liver metastases was found to be the worst prognostic factor in patients with metastatic lung adenocarcinoma (29). As stated by RIIHIMÄKI et al, patients with liver and bone metastases had a decreased survival rate when they had metastatic lung cancer (30).…”