139. Occult breast lesion localization and concomitant sentinel lymph node biopsy in early breast cancer (SNOLL)

Bordea, C; Blidaru, Alexandru; Condrea, Ileana; Gociman, A; Gherghe, Mirela

doi:10.1016/j.ejso.2014.08.136

Cited by 4 publications

(3 citation statements)

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“…Disease staging and sentinel lymph node biopsy were also studied by Carter [ 70 ], Gherghe [ 71 ], and Bordea [ 72 ], who show that standard treatment for women with clinically N0 breast cancer is sentinel lymph node biopsy (SLNB) and that it can also be associated, during the same intervention, with the localization of an occult breast lesion. However, there are no randomized controlled trials determining the optimal surgical management of the axilla in men.…”

Section: Resultsmentioning

confidence: 99%

An Update on the General Features of Breast Cancer in Male Patients—A Literature Review

et al. 2022

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Male breast cancers are uncommon, as men account for less than 1 percent of all breast carcinomas. Among the predisposing risk factors for male breast cancer, the following appear to be significant: (a) breast/chest radiation exposure, (b) estrogen use, diseases associated with hyper-estrogenism, such as cirrhosis or Klinefelter syndrome, and (c) family health history. Furthermore, there are clear familial tendencies, with a higher incidence among men who have a large number of female relatives with breast cancer and (d) major inheritance susceptibility. Moreover, in families with BRCA mutations, there is an increased risk of male breast cancer, although the risk appears to be greater with inherited BRCA2 mutations than with inherited BRCA1 mutations. Due to diagnostic delays, male breast cancer is more likely to present at an advanced stage. A core biopsy or a fine needle aspiration must be performed to confirm suspicious findings. Infiltrating ductal cancer is the most prevalent form of male breast cancer, while invasive lobular carcinoma is extremely uncommon. Male breast cancer is almost always positive for hormone receptors. A worse prognosis is associated with a more advanced stage at diagnosis for men with breast cancer. Randomized controlled trials which recruit both female and male patients should be developed in order to gain more consistent data on the optimal clinical approach.

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Section: Resultsmentioning

confidence: 99%

An Update on the General Features of Breast Cancer in Male Patients—A Literature Review

et al. 2022

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“…However, this practice has raised challenges in clinical decision-making, particularly concerning the identification and biopsy of the sentinel node, as false-negative results have been observed [18]. SLNB has been named as "the gold standard" for axillary staging in early BC patients with clinically negative lymph nodes, resulting in significant morbidity decrease, as well as life quality improvement without the loss of diagnostic accuracy and prognostic information [48,49]. With the increasing use of NAC, questions have arisen about the accuracy of SLNB in this particular context, especially in patients with larger tumours, but several trials have demonstrated that SLNB can be safely performed after NAC in these patients [15,50,51].…”

Section: Discussionmentioning

confidence: 99%

Feasibility of Sentinel Lymph Node Biopsy in Breast Cancer Patients with Axillary Conversion after Neoadjuvant Chemotherapy—A Single-Tertiary Centre Experience and Review of the Literature

Lazar,

Mutuleanu,

Spiridon

et al. 2023

Diagnostics

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(1) Introduction: Sentinel lymph node biopsy (SLNB) is widely used in breast cancer patients who undergo neoadjuvant chemotherapy (NAC), replacing axillary lymph node dissection. While commonly accepted for cN0 patients, its role in cN1/2 patients remains controversial. Our study aims to investigate the role of SLNB in BC patients who underwent prior NAC and compare our results to those of other studies presented in the literature. (2) Materials and methods: Our retrospective study included 102 breast cancer patients who received NAC before 99mTc-albumin Nanocolloid SLN mapping and SLNB was performed, completed or not with axillary dissection. A review based on the PRISMA statement was also carried out, encompassing 20 studies. (3) Results: The lymphoscintigraphy performed after the administration of NAC presented an identification rate (IR) of 93.13%. IR for SLNB was 94.11%, with a false-negative rate (FNR) of 7.4%. After a median follow-up of 31.3 months, we obtained a distant disease-free survival rate of 98%. The results obtained by other groups were similar to those of our study, presenting IR in the range 80.8–96.8%, with FNR varying from 0 to 22%. (4) Conclusions: on conclusion, SLNB can accurately determine the lymph node status, with an acceptable FNR and maintain its expected prognostic role with low recurrence rates, and our results are comparable to those obtained by other studies.

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“…This comes as a surprise, since in Romania access to healthcare is guaranteed by the constitution, the healthcare system is based on equality of accessibility to medical services regardless of financial contribution of each citizen and many underprivileged citizens are freely insured for healthcare. The statefunded system provides free access to preventive medical services; diagnostic procedures and investigations (including complex imaging that can help in differentiating between metastatic lesions and primary/other lesions [95,96] or diagnostic synchronous lesions [97]); all treatment options for both precursor lesions and for invasive cancer and simultaneous treatment of primary and metastatic lesions [98] through national treatment programs [99] (surgery-including novel techniques such as laparoscopy for both oncologic diagnosis and staging, radical or palliative treatment [100], robotic surgery, novel surgical techniques for cancer [101], sentinel lymph node identification with radioactive material, which has become the standard of care for some cancers [102], or indocyanine green [103], reconstructive surgery, identification of occult cancer lesions using radioactive colloids [104], radiotherapy, chemotherapy, immunotherapy [105], personalized oncological treatments and so on); and also for follow-up procedures and investigations. All being said, it becomes apparent that focused information campaigns are of paramount importance for resolving the problems that cervical cancer is causing in Romania, as health illiteracy is the primary reason for the current situation.…”

Section: Other Deterrents Of Attendance For Screening and Hpv Vaccine...mentioning

confidence: 99%

Inequities in Screening and HPV Vaccination Programs and Their Impact on Cervical Cancer Statistics in Romania

Simion,

Rotaru,

Cirimbei

et al. 2023

Diagnostics

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(1) Introduction: A Romanian woman is diagnosed with cervical cancer every two hours; the country ranks second in Europe in terms of the mortality and incidence rate of this disease. This paper aims to identify the main reasons that have led to this situation, focusing on the measures taken by the Romanian Ministry of Health for the prevention of this type of cancer—national programs for cervical cancer screening and HPV vaccination. (2) Materials and methods: We performed a study based on the available secondary data from the National Statistics Institute, World Health Organization and Bucharest Institute of Oncology in order to assess the burden associated with cervical cancer and place it in the context of known global and European incidence and mortality rates, thus evaluating the importance of this health issue in Romania. The second component of our study was a cross-sectional study. Here, we used a 14-question questionnaire applied to the women participating in the National Screening Program for Cervical Cancer and aimed to evaluate the women’s level of knowledge about screening and HPV vaccination and their access cervical-cancer-specific healthcare services. (3) Results: The results of this research show that a high percentage of women postpone routine checks due to a lack of time and financial resources and indicate that a low level of knowledge about the disease and the specific preventive methods determines the low participation in screening and HPV vaccination programs implemented in Romania, contributing to the country’s cervical cancer situation. (4) Conclusions: The national programs have complicated procedures, are underfunded and do not motivate healthcare workers enough. This, combined with the lack of information for the eligible population, adds up to an extremely low number of women screened and vaccinated. Our conclusion is that the Romanian Ministry of Health must take immediate action by conducting major awareness campaigns, implementing measures to make the programs functional and ensuring coherent funding.

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139. Occult breast lesion localization and concomitant sentinel lymph node biopsy in early breast cancer (SNOLL)

Cited by 4 publications

References 0 publications

An Update on the General Features of Breast Cancer in Male Patients—A Literature Review

An Update on the General Features of Breast Cancer in Male Patients—A Literature Review

Feasibility of Sentinel Lymph Node Biopsy in Breast Cancer Patients with Axillary Conversion after Neoadjuvant Chemotherapy—A Single-Tertiary Centre Experience and Review of the Literature

Inequities in Screening and HPV Vaccination Programs and Their Impact on Cervical Cancer Statistics in Romania

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