13C NMR of flavonoids—II

Markham, Kenneth R.; Ternai, B.

doi:10.1016/0040-4020(76)88036-2

Cited by 255 publications

(80 citation statements)

References 8 publications

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“…UV spectrum was determined with a JASCO V-530 spectrophotometer. Nuclear magnetic resonance (NMR) spectra for 1 H, and 13 C were taken on Varian UNITY plus 300 spectrometer and Varian Unity INOVA 500 spectrometer. Chemical shifts were expressed in parts per million (ppm) relative to TMS as the internal standard and coupling constants (J) were given in Hz.…”

Section: Methodsmentioning

confidence: 99%

Cytotoxic Allyl Retrochalcone from the Roots of Glycyrrhiza inflata

2005

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Section: Methodsmentioning

confidence: 99%

Cytotoxic Allyl Retrochalcone from the Roots of Glycyrrhiza inflata

2005

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“…The known compounds were identified as quercetin 3-O-b-D-(6 00 -n-butyl glucuronide) (2) (6), quercetin-3-Oa-rhamnopyranoside (quercitrin) (7) (Badria et al 2007), astragalin (8) (Markham & Ternai 1976), (Badria et al 2007), taxifolin (10) (Kim et al 2009), (+)-catechin (11), dehydrodicatechin A (12), quercetin (13), kaempferol (14) (Badria et al 2007) based on spectroscopic analysis and comparison with literature data.…”

Section: Isolation Of Flavonoids From C Polygonoidesmentioning

confidence: 99%

Flavonoids ofCalligonum polygonoidesand their cytotoxicity

Ahmed

Moawad

Owis

et al. 2016

Pharmaceutical Biology

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Context Calligonum polygonoides L. subsp. comosum L' Hér. (Polygonaceae), locally known as ''arta'', is a slow-growing small leafless desert shrub. Objective Isolation, structure elucidation and evaluation of cytotoxic activity of flavonoids from C. polygonoides aerial parts. Materials and methods Flavonoids in the hydroalcoholic extract of the of C. polygonoides were isolated and purified using column chromatography and preparative HPLC. The structures of the isolated flavonoids were elucidated on the basis of spectroscopic data including 2D NMR techniques. The cytotoxic activity of the isolated flavonoids (6.25, 25, 50 and 100 mg/mL) was evaluated against liver HepG2 and breast MCF-7 cancer cell lines using sulphorhodamine-B assay.00 -n-butyl glucuronide) (1), and 13 known flavonoids, quercetin 3-O-b-D-(6 00 -n-butyl glucuronide) (2), kaempferol-3-O-b-D-(6 00 -methyl glucuronide) (3), quercetin-3-O-b-D-(6 00 -methyl glucuronide) (4), quercetin-3-O-glucuronide (5), kaempferol-3-O-glucuronide (6), quercetin-3-O-a-rhamnopyranoside (7), astragalin (8), quercetin-3-O-glucopyranoside (9), taxifolin (10), (+)-catechin (11), dehydrodicatechin A (12), quercetin (13), and kaempferol (14), were isolated from the aerial parts of C. polygonoides. Quercetin showed significant cytotoxic activity against HepG2 and MCF-7 cell lines with IC 50 values of 4.88 and 0.87 mg/mL, respectively. Structure-activity relationships were analyzed by comparing IC 50 values of several pairs of flavonoids differing in one structural element. Discussion and conclusion The activity against breast cancer cell lines decreased by glycosylation at C-3. The presence of 2,3-double bond in ring C, carbonyl group at C-4 and 3',4'-dihydroxy substituents in ring B are essential structural requirements for the cytotoxic activity against breast cancer cells. ARTICLE HISTORY

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“…Other more recent studies, which are not inevitably on the OMWW but on some compounds, belong to the same family [39,[57][58]. According to the work in the literature on organic compounds, polyphenols and flavonoids (antioxidants) [9,[39][40]47,53,[56][57][58][59][60][61][62][63][64][65][66]. Typical 13 C NMR spectra are presented in (Fig.…”

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confidence: 99%