13N-Ammonia Combined With 18F-FDG Could Discriminate Between Necrotic High-Grade Gliomas and Brain Abscess

Abstract

13N-ammonia is effective in distinguishing brain abscess from necrotic high-grade gliomas, and its combination with 18F-FDG could further elevate the diagnostic accuracy.

Differentiation of suprasellar meningiomas from non-functioning pituitary macroadenomas by 18F-FDG and 13N-Ammonia PET/CT

“…For NFPMAs, there were 2(14.3%), 8(57.1%), 4(28.6%) of the 14 cases showed low, moderate and high metabolism respectively on 18 F-FDG images and 3(21.4%), 8(57.1%), 3(21.4%) of the 14 cases showed low, moderate and high metabolism respectively on 13 N-ammonia images. For SSMs, there were 7(63.6%), 4(36.4%) of the 11 cases showed low and moderate metabolism respectively on 18 F-FDG images and 11(100%) of the 11 cases showed high metabolism on 13 N-ammonia images.…”

“…About Forty-five minutes after an intravenous injection of 18 F-FDG (5.18 MBq/kg) and five minutes after an intravenous injection of 13 N-ammonia (370-740 MBq), a 10-minute PET/CT scan started. 18 F-FDG and 13 Nammonia studies were performed at least 24h apart.…”

“…MRI should be complemented by PET in whether diagnosis and staging before treatment or postoperative therapeutic effectiveness monitoring [9] . 13 N-ammonia is suggested to be a contrast-enhanced radiotracer which is more sensitive and specific than Gadolinium-Diethylenetriaminepentaacetic acid (Gd-DTPA) [10] . We have reported the clinical usefulness of 13 N-ammonia in many brain tumors through a series of studies [11][12][13][14] .…”

“…13 N-ammonia is suggested to be a contrast-enhanced radiotracer which is more sensitive and specific than Gadolinium-Diethylenetriaminepentaacetic acid (Gd-DTPA) [10] . We have reported the clinical usefulness of 13 N-ammonia in many brain tumors through a series of studies [11][12][13][14] . In addition, 13 Nammonia is also a potential tracer targeting glutamine synthetase (GS) expression which is associated with ammonia-glutamine synthesis reaction [15] .…”

“…We have reported the clinical usefulness of 13 N-ammonia in many brain tumors through a series of studies [11][12][13][14] . In addition, 13 Nammonia is also a potential tracer targeting glutamine synthetase (GS) expression which is associated with ammonia-glutamine synthesis reaction [15] . In this study, we aimed to investigate the combined efficiency of 18 F-FDG and 13 N-ammonia PET/CT in distinguishing SSMs from NFPMAs.…”