13N-ammonia positron emission tomography-derived left-ventricular strain in patients after heart transplantation validated using cardiovascular magnetic resonance feature tracking as reference

Kawakubo, Masateru; Nagao, Michinobu; Kikuchi, Noriko; Yamamoto, Atsushi; Nakao, Risako; Matsuo, Yosuke; Kaneko, Koichiro; Watanabe, Eri; Sasaki, Masayuki; Nunoda, Shinichi; Sakai, Shuji

doi:10.1007/s12149-021-01686-5

Cited by 7 publications

(4 citation statements)

References 22 publications

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“…This method was also used to evaluate right ventricular myocardial longitudinal strain to detect reduced right ventricular myocardial motion due to ischemia in the right coronary artery territory (29). Separately, Kawakubo et al evaluated the LV strain in heart transplant patients and validated 13 N-ammonia PET strains using CMR feature tracking strains (29). Compared with previous studies, our study validates PET MPI-derived strain measurements with resting 2D TTE-derived strain.…”

Section: Discussionsupporting

confidence: 55%

“…The use of PET imaging to measure LV strain has not been well established for routine clinical practice, but some publications demonstrated PET study-derived stain in potential clinical settings. Recent publications from Kawakubo et al (28,29) showed the utility of 13 N-ammonia PET MPI to measure LV strain. They studied endocardial strain and used it to compare blood flow and myocardial motility in ischemic patients (28).…”

Section: Discussionmentioning

confidence: 99%

“…They studied endocardial strain and used it to compare blood flow and myocardial motility in ischemic patients (28). This method was also used to evaluate right ventricular myocardial longitudinal strain to detect reduced right ventricular myocardial motion due to ischemia in the right coronary artery territory (29). Separately, Kawakubo et al evaluated the LV strain in heart transplant patients and validated 13 N-ammonia PET strains using CMR feature tracking strains (29).…”

Section: Discussionmentioning

confidence: 99%

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Left Ventricular Strain from Myocardial Perfusion PET Imaging: Method Development and Comparison to 2-Dimensional Echocardiography

et al. 2022

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This study aimed to develop a measure of longitudinal, radial, and circumferential myocardial strain at rest and regadenoson during pharmacologic stress using 82 Rb PET electrocardiography-gated myocardial perfusion imaging (MPI). Methods: We retrospectively identified 80 patients who underwent rest and regadenoson-stress CT attenuationcorrected 82 Rb PET and had a standard resting transthoracic echocardiogram (TTE) with global longitudinal strain (GLS) analysis within 3 mo. A method was developed to compute longitudinal, radial, and circumferential strain from PET MPI at stress and rest. PET MPI-derived strain and left ventricular function were compared with resting TTE measures as the clinical reference standard. Interobserver agreement of PET MPI strain and left ventricular ejection fraction processing was reported. Results: Longitudinal strain assessed with resting TTE GLS showed good correlation with PET MPI at stress (r 5 0.68, P , 0.001) and rest (r 5 0.58, P , 0.001). Resting TTE GLS also correlated with PET MPI radial strain at stress (r 5 20.70, P , 0.001) and rest (r 5 20.59, P , 0.001) and circumferential strain at stress (r 5 0.67, P , 0.001) and rest (r 5 0.69, P , 0.001). The left ventricular ejection fraction showed good correlation between resting TTE and PET MPI at stress (r 5 0.83, P , 0.001) and rest (r 5 0.80, P , 0.001). Bland-Altman analysis indicated positive bias of TTE GLS compared with PET MPI longitudinal strain at stress (mean difference 5 5.1%, 95% CI 5 [22.5, 12.7]) and rest (mean difference 5 4.2%, 95% CI 5 [24.3, 12.8]). Reproducibility of PET MPI longitudinal strain showed good agreement at stress (concordance correlation coefficient 5 0.73, P , 0.001) and rest (concordance correlation coefficient 5 0.74, P , 0.001), with Bland-Altman analysis showing a small bias in the longitudinal direction at stress (mean difference 5 20.2%) and rest (mean difference 5 21.0%). Conclusion:Strain measured with PET MPI using an automated technique correlated well with resting GLS strain obtained by TTE, and the measure is reproducible. Strain from PET MPI should be investigated further to establish reference ranges and assess its value in routine clinical practice.

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Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Left Ventricular Strain from Myocardial Perfusion PET Imaging: Method Development and Comparison to 2-Dimensional Echocardiography

et al. 2022

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“…Time resolution is an important factor in strain analysis, and the 16 frames/cycle time resolution is inferior to echocardiography, making strain rate evaluation difficult. However, PET strain has been proven to have a significant correlation with cine MRI strain with comparable temporal resolution of 20 frames/cycle (9). In terms of objectivity and reproducibility, it is considered to be no less than echocardiography.…”

Section: Discussionmentioning

confidence: 99%

Myocardial Strain Derived from <sup>13</sup>N-ammonia Positron Emission Tomography

Nagao

Kawakubo

Yamamoto

et al. 2022

Annals of Nuclear Cardiology

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Background: Due to the limitation of spatial resolution, cardiac nuclear medicine images have not been applied to feature-tracking method to automatic extraction of myocardial contours. We have successfully applied the feature-tracking method to high-resolution cine 13 N-ammonia positron emission tomography (PET) images to calculate the regional myocardial strains. Here, we investigate the potential of 13 N-ammonia PET-derived strain to detect ischemia-related wall motion abnormality. Methods: Data of adenosine-stress/rest 13 N-ammonia PET for 95 coronary artery disease patients was retrospectively analyzed. Using an original algorithm dedicated to 13 N-ammonia PET, the longitudinal strain (LS) corresponding to the three main coronary artery territories [right coronary artery (RCA), left anterior descending artery (LAD), and left circumflex coronary artery (LCX)] was calculated from semi-automatic endocardial contours extraction on cine 13 N-ammonia PET images of the left ventricular long-axis. The presence of ischemia in three main territories was determined from rest and stress-perfusion images. Results: In all three coronary territories, LS at stress was significantly smaller at rest in the ischemic region RCA:-19.2±8.0% vs. -22.7±6.1%, LAD: -19.0±6.9% vs. -24.4±6.4%, LCX: -20.5%±7.6% vs. -22.6±6.9%). In contrast, in the non-ischemic region, there was no significant difference between the LS at stress and at rest. Receiver-operating-characteristic analysis revealed that using the optimal cutoff of the LS ratio of stress to rest, ischemia could be diagnosed with area under the curve of 0.82 in the RCA, 0.86 in the LAD, and 0.69 in the LCX. Conclusions: Myocardial strain derived from endocardial feature-tracking of 13 N-ammonia PET cine imaging is reduced in the ischemia induced by adenosine-stress. The LS ratio of stress to rest may detect wall motion abnormality related to ischemia.

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Feasibility of position emission tomography derived endocardial wall strain: direct comparison with magnetic resonance using hybrid 13N ammonia PETMR system

Katahira,

Fukushima,

Endo

et al. 2024

Ann Nucl Med

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13N-ammonia positron emission tomography-derived left-ventricular strain in patients after heart transplantation validated using cardiovascular magnetic resonance feature tracking as reference

Abstract: N-ammonia positron emission tomography-derived left ventricular strain in patientsafter heart transplantation validated using cardiovascular magnetic resonance feature tracking as reference

Cited by 7 publications

References 22 publications

Left Ventricular Strain from Myocardial Perfusion PET Imaging: Method Development and Comparison to 2-Dimensional Echocardiography

Left Ventricular Strain from Myocardial Perfusion PET Imaging: Method Development and Comparison to 2-Dimensional Echocardiography

Myocardial Strain Derived from <sup>13</sup>N-ammonia Positron Emission Tomography

Feasibility of position emission tomography derived endocardial wall strain: direct comparison with magnetic resonance using hybrid 13N ammonia PETMR system

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