13N-NH3 Versus F-18 FDG in Detection of Intracranial Meningioma

Zhang, Xiangsong; Xingchong, Shi; Chen, Yi; Wang, Xiaoyan; Chen, Zhifeng

doi:10.1097/rlu.0b013e3182291c2a

Cited by 25 publications

(30 citation statements)

References 21 publications

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“…11C-acetate, another lipid PET tracer, showed high uptake in all 20 meningiomas, in contrast to the low uptake in surrounding normal brain tissue19, whereas with FDG 17 foci appeared photopenic and 3 hyper-intense. 13N-ammonia also had relatively greater uptake in 10 meningiomas when compared with FDG 20. Aminoacid PET tracers are also capable of demonstrating meningiomas: for delineation of gross tumour volume in stereotactic radiotherapy using 11 C-methionine21, or in recurrent cases using 18 F-fluoroethyltyrosine22, or in one patient referred to FDOPA PET for Parkinson’s disease 23.…”

Section: Discussionmentioning

confidence: 99%

Incidental uptake of ¹⁸F-fluorocholine (FCH) in the head or in the neck of patients with prostate cancer

Hodolič

Huchet

Balogova

et al. 2014

Radiology and Oncology

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BackgroundPositron emission tomography-computed tomography (PET/CT) with 18F-fluorocholine (FCH) is routinely performed in patients with prostate cancer. In this clinical context, foci of FCH uptake in the head or in the neck were considered as incidentalomas, except for those suggestive of multiple bone metastases.ResultsIn 8 patients the incidental focus corresponded to a benign tumour. The standard of truth was histology in two cases, correlative imaging with MRI in four cases, 99mTc-SestaMIBI scintigraphy, ultrasonography and biochemistry in one case and biochemistry including PTH assay in one case. The final diagnosis of benign tumours consisted in 3 pituitary adenomas, 2 meningiomas, 2 hyperfunctioning parathyroid glands and 1 thyroid adenoma.Malignancy was proven histologically in 2 other patients: 1 papillary carcinoma of the thyroid and 1 cerebellar metastasis.ConclusionsTo the best of our knowledge, FCH uptake by pituitary adenomas or hyperfunctioning parathyroid glands has never been described previously. We thus discuss whether there might be a future indication for FCH PET/CT when one such tumour is already known or suspected: to detect a residual or recurrent pituitary adenoma after surgery, to guide surgery or radiotherapy of a meningioma or to localise a hyperfunctioning parathyroid gland. In these potential indications, comparative studies with reference PET tracers or with 99mTc-sestaMIBI in case of hyperparathyroidism could be undertaken.

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Section: Discussionmentioning

confidence: 99%

Incidental uptake of ¹⁸F-fluorocholine (FCH) in the head or in the neck of patients with prostate cancer

Hodolič

Huchet

Balogova

et al. 2014

Radiology and Oncology

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“…Meanwhile, 2 out of 16 grade II lesions displayed higher uptake of 13 N-ammonia than normal gray matter, one of which also displayed avid uptake of 18 F-FDG and was confirmed with inflammatory infiltration finally (Fig. 14,16 However, most meningiomas have extremely high uptake of 13 Nammonia and very low uptake of 18 F-FDG, while PCNSLs have highest uptake of 18 F-FDG and relatively lower uptake of 13 Nammona. Macrophages are not only avid glucose consumers; they also disrupt the BBB and facilitate the uptake of 13 N-ammonia.…”

Section: Discussionmentioning

confidence: 91%

The Comparison of 13N-Ammonia and 18F-FDG in the Evaluation of Untreated Gliomas

Shi

Liu

Zhang

et al. 2013

Clinical Nuclear Medicine

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“…Apart from abnormal metabolic processes, CNS tumors also show increased perfusion, which can be visualized using [ 13 N]ammonia ([ 13 N]NH 3 ). The use of [ 13 N]NH 3 to study cerebral blood flow has been performed in patients with glioma, brain metastases, and meningioma [87][88][89][90][91]. Xiangsong et al showed increased tracer uptake to be present in 95% of MR contrast-enhancing lesions, suggesting BBB dependency [88].…”

Section: Diagnostic Imaging Of Increased Perfusionmentioning

confidence: 99%

The Added Value of Diagnostic and Theranostic PET Imaging for the Treatment of CNS Tumors

Pruis

Dongen

Zanten

2020

IJMS

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This review highlights the added value of PET imaging in Central Nervous System (CNS) tumors, which is a tool that has rapidly evolved from a merely diagnostic setting to multimodal molecular diagnostics and the guidance of targeted therapy. PET is the method of choice for studying target expression and target binding behind the assumedly intact blood–brain barrier. Today, a variety of diagnostic PET tracers can be used for the primary staging of CNS tumors and to determine the effect of therapy. Additionally, theranostic PET tracers are increasingly used in the context of pharmaceutical and radiopharmaceutical drug development and application. In this approach, a single targeted drug is used for PET diagnosis, upon the coupling of a PET radionuclide, as well as for targeted (nuclide) therapy. Theranostic PET tracers have the potential to serve as a non-invasive whole body navigator in the selection of the most effective drug candidates and their most optimal dose and administration route, together with the potential to serve as a predictive biomarker in the selection of patients who are most likely to benefit from treatment. PET imaging supports the transition from trial and error medicine to predictive, preventive, and personalized medicine, hopefully leading to improved quality of life for patients and more cost-effective care.

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13N-NH3 Versus F-18 FDG in Detection of Intracranial Meningioma

Abstract: These preliminary results suggest that (13)N-NH(3) has relatively greater uptake in meningiomas in comparison with F-18 FDG. Clinical applications of (13)N-NH(3) PET for grading and follow-up of meningiomas need to be assessed in further studies.

Cited by 25 publications

References 21 publications

Incidental uptake of ¹⁸F-fluorocholine (FCH) in the head or in the neck of patients with prostate cancer

Incidental uptake of ¹⁸F-fluorocholine (FCH) in the head or in the neck of patients with prostate cancer

The Comparison of 13N-Ammonia and 18F-FDG in the Evaluation of Untreated Gliomas

The Added Value of Diagnostic and Theranostic PET Imaging for the Treatment of CNS Tumors

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13N-NH3 Versus F-18 FDG in Detection of Intracranial Meningioma

Abstract: These preliminary results suggest that (13)N-NH(3) has relatively greater uptake in meningiomas in comparison with F-18 FDG. Clinical applications of (13)N-NH(3) PET for grading and follow-up of meningiomas need to be assessed in further studies.

Cited by 25 publications

References 21 publications

Incidental uptake of 18F-fluorocholine (FCH) in the head or in the neck of patients with prostate cancer

Incidental uptake of 18F-fluorocholine (FCH) in the head or in the neck of patients with prostate cancer

The Comparison of 13N-Ammonia and 18F-FDG in the Evaluation of Untreated Gliomas

The Added Value of Diagnostic and Theranostic PET Imaging for the Treatment of CNS Tumors

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Product

Resources

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Incidental uptake of ¹⁸F-fluorocholine (FCH) in the head or in the neck of patients with prostate cancer

Incidental uptake of ¹⁸F-fluorocholine (FCH) in the head or in the neck of patients with prostate cancer