14-3-3η in “Seronegative” Rheumatoid Arthritis

Naides, Stanley J.; Marotta, A.

doi:10.3899/jrheum.150330

Cited by 8 publications

(7 citation statements)

References 2 publications

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“…However, in both early and established RA, a higher prevalence of 14-3-3h (68%) was reported compared to our pediatric population [21,22]. In a previous report, 14-3-3h was positive in 21% of patients with early RA who were seronegative for RF and CCP antibodies, and in 67% of patients with seronegative established RA and in a pediatric study, 31% of PJIA RF-patients had positive 14-3-3h levels [16,23]. This differs from our results, which showed a much lower frequency (8%) in the PJIA RFgroup.…”

Section: Discussionmentioning

confidence: 48%

“…Serum 14-3-3h was found to be a predictive biomarker to determine evolving RA and radiographic changes in early RA [11,12]. Even though elevated 14-3-3h was reported to be associated with radiographic damage and disease progression in adults with established RA, no signi cant association between positive 14-3-3h and Disease Activity Score -28 (DAS28) was reported [10,23]. In our cohort, we also did not note any association between positive 14-3-3h and JADAS-71 in children with JIA [10].…”

Section: Discussionmentioning

confidence: 99%

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Prevalence and Significance of Serum 14-3-3η in Juvenile Idiopathic Arthritis

Reyhan¹,

Zhukov²,

Lagier³

et al. 2020

Preprint

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Background: Prompt diagnosis of juvenile idiopathic arthritis (JIA) is important to avoid long term complications. Elevated serum 14-3-3η levels improve the diagnostic sensitivity of rheumatoid factor (RF) and cyclic citrullinated peptide (CCP) antibody in adult rheumatoid arthritis (RA), and have been associated with more severe phenotype. We investigated the prevalence and clinical significance of serum 14-3-3η in different types of JIA.Methods: JIA patients (n=151) followed by the Pediatric Rheumatology Core at Children’s Hospital of Los Angeles were categorized into 5 groups: polyarticular JIA RF+ (PJIA RF+; n=39), PJIA RF- (n=39), psoriatic arthritis (PsA; n=19), enthesitis-related arthritis (ERA; n=18), and oligoarticular JIA (OJIA [control group]; n=36). RF, CCP antibody, and 14-3-3η were measured for all patients. 14-3-3η serum levels >0.2ng/mL were considered positive. Disease activity was assessed by the Juvenile Arthritis Disease Activity Score-71 (JADAS-71). Results: Elevated 14-3-3h levels were detected in 34/151 (23%) patients, and across all groups tested. Most patients with 14-3-3h had titers ≥4 times above the cutoff value. The majority (22, 65%) of 14-3-3h-positive patients were also positive for RF or CCP antibodies, 16 (47%) were positive for all 3, and 12 (35%) were single-positive for 14-3-3η. The highest prevalence of 14-3-3η was in PJIA RF+ patients (49%), followed by OJIA (22%). Positivity for 14-3-3h was not significantly associated with disease activity or age at diagnosis. Conclusion: Serum 14-3-3h can be detected in all forms of JIA tested but appears to be most common in PJIA RF+. 14-3-3h does not appear to correlate with disease activity in JIA.

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Section: Discussionmentioning

confidence: 48%

Section: Discussionmentioning

confidence: 99%

Prevalence and Significance of Serum 14-3-3η in Juvenile Idiopathic Arthritis

Reyhan¹,

Zhukov²,

Lagier³

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, in both early and established RA, a higher prevalence of 14-3-3η (68%) was reported compared to our pediatric population [17,18]. In a previous report, 14-3-3η was positive in 21% of patients with early RA who were seronegative for RF and CCP antibodies, and in 67% of patients with seronegative established RA and in a pediatric study, 31% of PJIA RF-patients had positive 14-3-3η levels [15,19]. This differs from our results, which showed a much lower frequency (8%) in the PJIA RF-group.…”

Section: Discussionmentioning

confidence: 50%

“…Serum 14-3-3η was found to be a predictive biomarker to determine evolving RA and radiographic changes in early RA [10,11]. Even though elevated 14-3-3η was reported to be associated with radiographic damage and disease progression in adults with established RA, no significant association between positive 14-3-3η and Disease Activity Score -28 (DAS28) was reported [9,19]. In our cohort, we also did not note any association between positive 14-3-3η and JADAS-71 in children with JIA [9].…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Significance of Serum 14-3-3η(eta) in Juvenile Idiopathic Arthritis

Reyhan

Zhukov

Lagier

et al. 2020

Preprint

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Background Prompt diagnosis of juvenile idiopathic arthritis (JIA) is important to avoid long term complications. Elevated serum 14-3-3η levels improve the diagnostic sensitivity of rheumatoid factor (RF) and cyclic citrullinated peptide (CCP) antibody in adult rheumatoid arthritis (RA), and have been associated with more severe phenotype. We investigated the prevalence and clinical significance of serum 14-3-3η in different types of JIA.Methods JIA patients (n = 152) followed by the Pediatric Rheumatology Core at Children’s Hospital of Los Angeles were categorized into 5 groups: polyarticular JIA RF+ (PJIA RF+; n = 39), PJIA RF- (n = 39), psoriatic arthritis (PsA; n = 20), enthesitis-related arthritis (ERA; n = 18), and oligoarticular JIA (OJIA [control group]; n = 36). RF, CCP antibody, and 14-3-3η were measured for all patients. 14-3-3η serum levels ≥ 0.2 ng/mL were considered positive. Disease activity was assessed by the Juvenile Arthritis Disease Activity Score-71 (JADAS-71).Results Elevated 14-3-3η levels were detected in 35/152 (23%) patients, and across all groups tested. Most patients with 14-3-3η had titers ≥ 4 times above the cutoff value. The majority (23, 67%) of 14-3-3η-positive patients were also positive for RF or CCP antibodies, 17 (49%) were positive for all 3, and 12 (8%) were single-positive for 14-3-3η. The highest prevalence of 14-3-3η was in PJIA RF + patients (49%), followed by OJIA (22%). Positivity for 14-3-3η was not significantly associated with disease activity or age at diagnosis.Conclusion Serum 14-3-3η can be detected in all forms of JIA tested but appears to be most common in PJIA RF+. 14-3-3η does not appear to correlate with disease activity in JIA.

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“…However, in both early and established RA, a higher prevalence of 14–3-3η (68%) was reported compared to our pediatric population [ 21 , 22 ]. In a previous report, 14–3-3η was positive in 21% of patients with early RA who were seronegative for RF and CCP antibodies, and in 67% of patients with seronegative established RA and in a pediatric study, 31% of PJIA RF- patients had positive 14–3-3η levels [ 16 , 23 ]. This differs from our results, which showed a much lower frequency (8%) in the PJIA RF- group.…”

Section: Discussionmentioning

confidence: 97%

Prevalence and significance of serum 14–3-3η in juvenile idiopathic arthritis

et al. 2021

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Background Prompt diagnosis of juvenile idiopathic arthritis (JIA) is important to avoid long term complications. Elevated serum 14–3-3η levels improve the diagnostic sensitivity of rheumatoid factor (RF) and cyclic citrullinated peptide (CCP) antibody in adult rheumatoid arthritis (RA), and have been associated with more severe phenotype. We investigated the prevalence and clinical significance of serum 14–3-3η in different types of JIA. Methods JIA patients (n = 151) followed by the Pediatric Rheumatology Core at Children’s Hospital of Los Angeles were categorized into 5 groups: polyarticular JIA RF+ (PJIA RF+; n = 39), PJIA RF- (n = 39), psoriatic arthritis (PsA; n = 19), enthesitis-related arthritis (ERA; n = 18), and oligoarticular JIA (OJIA [control group]; n = 36). RF, CCP antibody, and 14–3-3η were measured for all patients. 14–3-3η serum levels > 0.2 ng/mL were considered positive. Disease activity was assessed by the Juvenile Arthritis Disease Activity Score-71 (JADAS-71). Results Elevated 14–3-3η levels were detected in 34/151 (23%) patients, and across all groups tested. Most patients with 14–3-3η had titers ≥4 times above the cutoff value. The majority (22, 65%) of 14–3-3η-positive patients were also positive for RF or CCP antibodies, 16 (47%) were positive for all 3, and 12 (35%) were single-positive for 14–3-3η. The highest prevalence of 14–3-3η was in PJIA RF+ patients (49%), followed by OJIA (22%). Positivity for 14–3-3η was not significantly associated with disease activity or age at diagnosis. Conclusion Serum 14–3-3η can be detected in all forms of JIA tested but appears to be most common in PJIA RF+. 14–3-3η does not appear to correlate with disease activity in JIA.

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14-3-3η in “Seronegative” Rheumatoid Arthritis

Cited by 8 publications

References 2 publications

Prevalence and Significance of Serum 14-3-3η in Juvenile Idiopathic Arthritis

Prevalence and Significance of Serum 14-3-3η in Juvenile Idiopathic Arthritis

Prevalence and Significance of Serum 14-3-3η(eta) in Juvenile Idiopathic Arthritis

Prevalence and significance of serum 14–3-3η in juvenile idiopathic arthritis

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