14. Taurine affects hematologic properties and diseases

Roysommuti, Sanya; Wyss, J. Michael

doi:10.3920/978-90-8686-822-3_14

Cited by 3 publications

(4 citation statements)

References 49 publications

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“…Metabolites showing negative correlation with Hct were alanine, glutamine, dimethylglycine, methionine, uric acid, isoleucine, phenylalanine, gamma-glutamyl-leucine (gamma-glu-leu), hippuric acid, taurocholic acid (TCA), glycocholic acid (GCA), taurochenodeoxycholic acid (TCDCA), and glycochenodeoxycholic acid (GCDCA). Previous studies have indicated that carnosine, taurine, creatine, and acetylcarnitine predominantly existed in red blood cells, − and the intensities of these compounds were increased with the increase of the Hct level. Amino acids including alanine, glutamine, methionine, isoleucine, and phenylalanine were reported to be highly concentrated in plasma compared to RBC. , Due to their high concentrations in plasma, the increase in the Hct value decreased their overall signal intensities.…”

Section: Resultsmentioning

confidence: 95%

Improved Dried Blood Spot-Based Metabolomics Analysis by a Postcolumn Infused-Internal Standard Assisted Liquid Chromatography-Electrospray Ionization Mass Spectrometry Method

Chepyala

Kuo

et al. 2019

Anal. Chem.

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Dried blood spots (DBSs) have gained increasing attention recently with their growing importance in precision medicine. DBS-based metabolomics analysis provides a powerful tool for investigating new biomarkers. Until now, very few studies have discussed measures for improving analytical accuracy with the consideration of the special characteristics of DBSs. The present study proposed a postcolumn infused-internal standard (PCI-IS) assisted strategy to improve data quality for DBS-based metabolomics studies. An efficient sample preparation protocol with 80% acetonitrile as the extraction solvent was first established to improve the metabolite recovery. The PCI-IS assisted liquid chromatography-electrospray ionization mass spectrometry (LC-ESI-MS) method was used to simultaneously estimate the blood volume and correct the signal change caused by ion source contamination and the matrix effect to evaluate the spot volume effect and hematocrit (Hct) variation effect on target metabolites. Phenylalanine-d 8 was selected as the single PCI-IS to correct the matrix effect. For calibration of errors caused by the blood volume difference, 75% of the test metabolites showed good correlation (R 2 ≥ 0.9) between the spot volume and the signal intensity after PCI-IS correction compared to less than 50% metabolites with good correlation before calibration. The spot volume was further calibrated by the same PCI-IS. Investigation of the Hct variation effect on target metabolites revealed that it affected the concentrations of metabolites in the DBS samples depending on their abundance in the red blood cell (RBC) or plasma; it is essential to preinvestigate the distribution of metabolites in blood to minimize the comparison bias in metabolomics studies. Finally, the PCI-IS assisted method was applied to study acetaminophen-induced liver toxicity. The results indicated that the proposed PCI-IS strategy could effectively remove analytical errors and improve the data quality, which would make the DBS-based metabolomics more feasible in real-world applications.

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Section: Resultsmentioning

confidence: 95%

Improved Dried Blood Spot-Based Metabolomics Analysis by a Postcolumn Infused-Internal Standard Assisted Liquid Chromatography-Electrospray Ionization Mass Spectrometry Method

Chepyala

Kuo

et al. 2019

Anal. Chem.

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“…Therefore, the strong positive association between PLT and AMP might be interpreted as intrinsic clot preventing process. Not at least, taurine was reported to influence PLT activity and aggregation . Interestingly, low PLT taurine was reported in diabetes and supplementation of taurine restored PLT dysfunction .…”

Section: Discussionmentioning

confidence: 99%

“…Not at least, taurine was reported to influence PLT activity and aggregation. 41 Interestingly, low PLT taurine was reported in diabetes and supplementation of taurine restored PLT dysfunction. 42 We like to note, that the PLT associations with taurine or serotonin did not translate to urine levels of these metabolites (both P > 0.20) further arguing for a local effect.…”

Section: Putative Surrogates Of Platelet Activationmentioning

confidence: 99%

Metabolic signature associated with parameters of the complete blood count in apparently healthy individuals

Masuch

Budde

Kastenmüller

et al. 2019

J Cellular Molecular Medi

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Metabolomics studies now approach large sample sizes and the health characterization of the study population often include complete blood count (CBC) results. Upon careful interpretation the CBC aids diagnosis and provides insight into the health status of the patient within a clinical setting. Uncovering metabolic signatures associated with parameters of the CBC in apparently healthy individuals may facilitate interpretation of metabolomics studies in general and related to diseases. For this purpose 879 subjects from the population‐based Study of Health in Pomerania (SHIP)‐TREND were included. Using metabolomics data resulting from mass‐spectrometry based measurements in plasma samples associations of specific CBC parameters with metabolites were determined by linear regression models. In total, 118 metabolites significantly associated with at least one of the CBC parameters. Strongest associations were observed with metabolites of heme degradation and energy production/consumption. Inverse association seen with mean corpuscular volume and mean corpuscular haemoglobin comprised metabolites potentially related to kidney function. The presently identified metabolic signatures are likely derived from the general function and formation/elimination of blood cells. The wealth of associated metabolites strongly argues to consider CBC in the interpretation of metabolomics studies, in particular if mutual effects on those parameters by the disease of interest are known.

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“…Taurine has also been linked to sperm preservation in hypothermia 62,64 . Hemato-protective effects: Taurine is required by blood cells, particularly neutrophils, lymphocytes and platelets 73 . Taurine is an essential component of energy drinks and healthy foods 74 .…”

Section: Treatment Of Metabolic Diseasesmentioning

confidence: 99%

Physio-Pharmacological Potentials of Taurine: A Review in Animal and Human Studies

Obukohwo

2023

Asian J. Biol. Sci

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Taurine, a sulfur-containing non-protein amino acid is one of the most prevalent amino acids in all mammalian plasma and tissues. The objective is to identify the therapeutic role of taurine in animal models and human systemic physiology. Various electronic databases, including author, year of publication, country, purpose, data collection, significant findings and research focus/domain were used in search of published material referencing assessment of the physio-pharmacological potentials of taurine. Taurine protects against a wide range of pathophysiological conditions, including neurological abnormalities, mitochondrial malfunction, metabolic disease, reproductive failure and poor fetal development. Taurine was also reviewed to possess antioxidant, reno-protective, hemo-protective, hepato-protective and anti-inflammatory potentials as well as cardio-protective and anti-aging effects. Taurine, found in excitable tissues, protects systemic physiology against maladaptive responses. Further research is needed to determine if taurine insufficiency can monitor maladaptive responses. Although, clinical trials are also needed to determine optimal therapeutic doses.

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14. Taurine affects hematologic properties and diseases

Cited by 3 publications

References 49 publications

Improved Dried Blood Spot-Based Metabolomics Analysis by a Postcolumn Infused-Internal Standard Assisted Liquid Chromatography-Electrospray Ionization Mass Spectrometry Method

Improved Dried Blood Spot-Based Metabolomics Analysis by a Postcolumn Infused-Internal Standard Assisted Liquid Chromatography-Electrospray Ionization Mass Spectrometry Method

Metabolic signature associated with parameters of the complete blood count in apparently healthy individuals

Physio-Pharmacological Potentials of Taurine: A Review in Animal and Human Studies

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