140 Variation of Erythropoietin Levels in Children With Chronic Renal Failuredefect of Direct Hematologic Compensation in Renalanemia

Abstract

U n i v e r s i t y o f Hamburg, 0-2000 Hamburg 20, FRG. P a t i e n t s with c l a s s i c a l HUS (n=22; median age 2;2 y r s ) were p r o s p e c t i v e l y s t u d i e d a t o u r i n s t i t u t i o n s i n c e 1986. SLT-association was e s t a b l i s h e d by c y t o t o r i c i t y a s s a y s o f f e c a l f i l t r a t e s , b a c t e r i a l i s o l a t i o n o r colony-blot-hybridizati-o n w i t h SLT-specific DNA probes. S e r i a l serum samples from 1 2 p t s and a p p r o p r i a t e c o n t r o l s were s t u d i e d f o r SLT I and I1 n e u t r a l i z i n g a n t i b o d i e s (NAB) and f o r h e m a g g l u t i n a t i n g a n t i b od i e s (HA) u s i n g e r y t h o c y t e s c o a t e d with p u r i f i e d LPS from E . c o l i 0157:H7 and o t h e r s e r o v a r s . SLT a s s o c i a t i o n was demonstrated i n 13/22 c h i l d r e n 159%); E.coli i s o l a t e s (n=6 p t s ) included serogroups 026, 055, 0111 and 0157; f e c a l SLT a l o n e was p r e s e n t i n 7 a d d i t i o n a l c a s e s . 4 p t s developed r i s i n g NAB-titers a g a i n s t SLT I o r 11; 9 p t s (75%) p r e s e n t e d w i t h h i g h LPS-0157-HA a t t h e time o f t h e d i a g n o s i s o f HUS t h a t r a p i d l y d e c l i n e d d u r i n g convalescence.Thus i n N o r t h e r n Germany a n a s s o c i a t i o n o f t h e c l a s s i c a l HUS w i t h in-vivo SLT p r o d u c t i o n h a s been confirmed. D e t e c t i o n o f LPS-0157-AB a p p e a r s t o be a new, v a l u a b l e s e r o l o g i c a l marker f o r t h i s subgroup o f HUS. F u r t h e r s t u d i e s a r e needed t o e l u c i d a t e a p o s s i b l e p r o t e c t i v e o r pathogenic r o l e o f SLT-and LPS-specific AB. Sauer. Sophia Children's Hosp., Rotterdam. The Netherlands. Furmulas specially designed for preterm infants contain up to 50% MCT because of their almost complete absorption. The effects of ,MCT(C8 and C10) on mineral absorption were studied in infants receiving formula (Nutricia,Holland) with 5%(LCT group) or 40C,(MCT group) of fat as MCT, providing 80 mg P-, I52 mg Ca-and 120 kcal/kg.d,+ 600 IU/day vit D. 72 hr balance studies were performed at 4 weeks of age. Values:mean 2 lsd or median with interquartile range. Plasma levels (MCT vs LCT) of Ca(2.42 0.1 vs 2.4f 0.1 mmol/L). P(2.2f 0.3 vs 2.320.2 mmol/L) and Alkaline Phosphatase ( 2 7 3 2 7 4~s 295f43 IU/L) were in the normal range. NITROGEN AND FAT DEPOSITION IN PRETERhI INFANTS FEDMCT on regular dialysis therapy (II). 34 after uanrplanution (Ul):variation of EPO concentration in children with these various slager of chronic renal failure (CRF) were compved to 40 conuols with nomcnal ancmia(1V)and healthy conuols ( V) .-0: relative EPO deficiency could be detected in I and less after renal mansplanration , an absolute deficiency wrr found on regular dialyris.An inverse linear melation between EPO levels and hemoglobin in IV Q E C W C~ however in Il the rise of EPO war LuuEciat mmpared to 1V.h our swdy we could demomuate successfully a feedback mechanism between EPO...