142 Efficacy and Safety of Traditional Chinese Medicine Qiaoshao Formula Combined with Dapoxetine in the Treatment of Premature Ejaculation in Chinese Men: a Real-world Study

Guo, Jing; Zhou, Qingde; Zhang, R.; Zhang, C.H.; Xuan, Zhihua; Cai, Jun; Zeng, X.B.; Bin, Bum-Ho; Chen, W.T.; Wang, F.; Qiu, Jun-Feng; Yan, Bin; Gao, Qi; Zhang, X.J.; Liu, Y.

doi:10.1016/j.jsxm.2018.04.144

Cited by 2 publications

(2 citation statements)

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“…In China, traditional herbs or formulas to treat ED are widespread and recognized for their effectiveness [12, 13]. The basic pathogenesis of ED after radical prostatectomy, in terms of traditional Chinese medicine, is considered a Qi deficiency and dysregulated blood stasis [14].…”

Section: Introductionmentioning

confidence: 99%

Effect of HongJing I in Treating Erectile Function and Regulating RhoA Pathway in a Rat Model of Bilateral Cavernous Nerve Injury

Zhao

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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HongJing I (HJI), a traditional Chinese herbal formula, has been confirmed to be effective for the clinical treatment of erectile dysfunction (ED). However, the mechanism of action of HJI remains unclear. Here, we aimed to investigate the effect and underlying mechanisms of HJI against ED in a rat model of bilateral cavernous nerve injury (BCNI). Rats were divided into five groups: normal control (NC), BCNI-induced ED model (M), M + low-dose HJI (HL), M + medium-dose HJI (HM), and M + high-dose HJI (HH). All groups were treated with normal saline or the relevant drug for 28 consecutive days after inducing BCNI-ED. At the end of the treatment period, the intracavernous pressure (ICP) was recorded, and histological examination was conducted using Masson’s trichrome staining. Immunofluorescence staining and western blotting were applied to detect the changes in fibrosis protein and Ras homolog A (RhoA), Rho-associated protein kinase 1 (ROCK1), and ROCK2 expression. We found that HJI effectively improved the ICP in the treatment groups. In addition, RhoA, ROCK1, and ROCK2 expression levels were increased upon BCNI-ED induction, and HJI successfully inhibited cavernosum fibrosis and the activation of RhoA/ROCK2 signaling. Overall, these results suggest that the effects of HJI in attenuating ED may be caused, at least in part, by the suppression of RhoA/ROCK2 signaling and alleviation of fibrosis. However, the precise mechanism surrounding this requires further investigation in future studies.

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Section: Introductionmentioning

confidence: 99%

Effect of HongJing I in Treating Erectile Function and Regulating RhoA Pathway in a Rat Model of Bilateral Cavernous Nerve Injury

Zhao

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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“…[6] In addition, Guo et al found that a formula containing Paeonia lactiflora and Cyperus rotundus could prolong IELT in PE rats, possibly related to an increase in 5-HT levels. [7] Han et al postulated that a formula to soothe the liver and benefit the gallbladder could improve behavioral characteristics in PE rats, reduce the expression of dopamine receptor messenger ribonucleic acid (mRNA) and protein, and simultaneously enhance the levels of dopamine transporter. [8] External treatment-herbal sprays, soaking therapy, and massage treatment External treatment in TCM for PE is characterized by distinct features, namely simplicity, efficacy, and excellent safety.…”

Section: Oral Treatment-herbal Decoctionsmentioning

confidence: 99%

A Review of Studies on the Treatment of Premature Ejaculation with Traditional Chinese Medicine

Ma,

Wang,

Wang

et al. 2024

Integr Med Nephrol Androl

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By combing the literature and analyzing the current status of traditional Chinese medicine (TCM) treatment for premature ejaculation (PE), the strengths and shortcomings of the existing studies were identified. Building upon this assessment, we put forward a prospect for the establishment of TCM-specific strategies for PE, including more targeted and individualized comprehensive diagnosis and treatment approaches for PE, the establishment of a TCM hierarchical management program, and the exploration of the most effective entry points for collaborative treatment of PE using both TCM and Western medicine. Indeed, integrating therapeutical strategies from the two perspectives in a multifaceted and complex symptom such as PE, would enhance the possibility of success, possibly also reducing side effects. Moreover, with the help of well-established and new scientific and technological tools, we can explore the key links and targets in treating PE by TCM. At the same time, the mechanism of TCM treatment for PE could and should be examined in depth to lay the foundation for widespread clinical application. Finally, we suggest conducting multicenter, nationwide standardized clinical studies on treating PE with TCM. These studies should employ high-quality randomized controlled trial designs to obtain robust evidence-based medical data.

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142 Efficacy and Safety of Traditional Chinese Medicine Qiaoshao Formula Combined with Dapoxetine in the Treatment of Premature Ejaculation in Chinese Men: a Real-world Study

Cited by 2 publications

References 0 publications

Effect of HongJing I in Treating Erectile Function and Regulating RhoA Pathway in a Rat Model of Bilateral Cavernous Nerve Injury

Effect of HongJing I in Treating Erectile Function and Regulating RhoA Pathway in a Rat Model of Bilateral Cavernous Nerve Injury

A Review of Studies on the Treatment of Premature Ejaculation with Traditional Chinese Medicine

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