145 POSTER Marked therapeutic efficacy of a novel poly(ethylene-glycol) conjugated SN38 conjugate in xenograft models of breast and colorectal cancers

Sapra, Puja; Longley, Clifford; Zhang, Z.; Zhao, Haijun; Rubio, B; Mehlig, Mary; Malaby, Jennifer; Conover, Cheryl A.; Greenberger, Lee M.; Horak, Ivan D.

doi:10.1016/s1359-6349(06)70151-3

Cited by 1 publication

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“…PEG-SN38 (EZN-2208): On November 9 th , 2006, Enzon Pharmaceutical Inc. announced new data providing preclinical proof-of-concept in breast, colorectal and pancreatic cancer for PEG-SN38. The data were presented at the 18 th EORTC-NCI-AACR annual meeting in Prague (38).…”

Section: Polymer-camptothecin Conjugatesmentioning

confidence: 99%

Polymer-drug conjugates: current status and future trends

Greco

Vicent²

2008

Front Biosci

104

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Polymer conjugates are nano-sized, multi-component constructs already in the clinic as anticancer compounds, both as single agents or as elements of combinations. They have the potential to improve pharmacological therapy of a variety of solid tumors. Polymer-drug conjugation promotes passive tumor targeting by the enhanced permeability and retention (EPR) effect and allows for lysosomotropic drug delivery following endocytic capture. In the first part of this review, we analyze the promising results arising from clinical trials of polymer-bound chemotherapy. The experience gained on these studies provides the basis for the development of a more sophisticated second-generation of polymer conjugates. However, many challenges still lay ahead providing scope to develop and refine this field. The ''technology platform'' of polymer therapeutics allows the development of both new and exciting polymeric materials, the incorporation of novel bioactive agents and combinations thereof to address recent advances in drug therapy. The rational design of polymer drug conjugates is expected to realize the true potential of these "nanomedicines".

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Section: Polymer-camptothecin Conjugatesmentioning

confidence: 99%