145. Temporal associations between IL-6 and cortisol production in response to acute psychosocial stress

Gawuga, Cyrena E; Tyrka, Audrey R.; Price, Lawrence H.; Carpenter, Linda L.

doi:10.1016/j.bbi.2012.07.169

Cited by 1 publication

(1 citation statement)

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“…Research findings are inconsistent regarding the relationship between IL-6 and cortisol. Some researchers suggest IL-6 and cortisol are positively correlated (Steensberg et al, 2003) while others suggest an inverse relationship exists between the two (Gawuga et al, 2012). In a review of the effects of stress on the GI tract, Mayer et al (2000) stated that the activation of the sympathetic nervous system stimulates the release of IL-6 which then activates the HPA axis.…”

Section: Discussionmentioning

confidence: 99%

Feeding intolerance, inflammation, and neurobehaviors in preterm infants

Moore

Pickler

2017

Journal of Neonatal Nursing

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Purpose Identifying relationships between feeding intolerance (FI), inflammation, and early measures of neurodevelopment may provide the basis for clinically relevant assessments for NICU clinicians and staff. The purpose of this secondary analysis was to examine the relationship of FI to inflammatory markers and/or neurobehaviors in the first week of life. Methods This was a retrospective, matched case-control design with data drawn from 114 infants born at ≤32 weeks gestation. Results Eight infants developed FI prior to full enteral feedings. These infants were more likely to have dysregulated levels of cytokines, specifically IL6, and lower neurodevelopmental scores compared to infants without FI. Conclusions Results suggest physiologic dysregulation and an immature nervous system may contribute to the phenomenon of FI in preterm infants. Further research to identify the role of the brain-gut-immune axis on FI and other GI complications in this population is warranted.

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Section: Discussionmentioning

confidence: 99%