1468P Characteristics and prognosis of gastric cancer (GC) in adolescents and young adults (AYA) in Singapore

Wong, Evelyn; Goh, Wei Lin; Hong, Jung Hee; Lam, Y.C.J.; Ng, Michael; Poon, Eileen

doi:10.1016/j.annonc.2020.08.1974

Cited by 2 publications

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“…This information shows that young female patients are predominantly diagnosed at metastatic disease stage (59%), with tumor location at stomach (70%), histological classification of diffuse type (68%), signet ring cell component (72%); and poor differentiation (90%). All clinical features related to a bad prognosis of OS and outcome in other studies worldwide ( 14 , 24 , 35 ). Thus, we performed a sub-analysis regarding clinical stage of the disease.…”

Section: Discussionmentioning

confidence: 77%

“…This study describes the incidence and mortality of Latin patients diagnosed with GC.This type of cancer is the second most common neoplasm within gastrointestinal pathologies in our hospital and one of the leading cancer diagnoses and mortality in our country and the Latin Hispanic population ( 21 , 22 ). Even though the incidence and mortality of GC is mostly in patients aged 50 years or more, in the past 30 years, the diagnosis of GC has increased in younger adults ( 5 , 23 , 24 ). In the present study the incidence of GC in younger population increased from 2% up to 18% between 2004 and 2019.…”

Section: Discussionmentioning

confidence: 99%

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Latin American young patients with gastric adenocarcinoma: worst prognosis and outcomes

Calderillo-Ruíz,

Díaz-Romero,

Carbajal-López

et al. 2023

J Gastrointest Oncol

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Background Incidence of young patients (aged 40 years or younger) diagnosed with gastric carcinoma has increased worldwide. Young GC diagnosis, have clinicopathological features that differ from elderly, and is correlated with bad prognosis factors. The purpose of this work is to describe the prevalence, clinic-pathological features, and prognosis of overall survival (OS) of young Latin-American patients with GC. Methods Retrospective, observational study. Included patients treated at the National Cancer Institute [2004–2020]. Statistical analysis: χ 2 and t -test, Kaplan-Meier, Log-Rank and Cox-Regression. Statistical significance differences were assessed when P was bilaterally <0.05. Results A total of 2,543 patients fulfilled the inclusion criteria. Young-patients were predominantly female (54%), with diffuse-type adenocarcinoma (68%), signet-ring-cell (72%), poor-differentiation (90%), and metastatic (79%). In OS analysis, patients with metastatic disease, showed differences regarding age, young patients reported a median-OS of 8 versus 13 months for elderly patients (P=0.001). Among young patients, differences were also observed regarding gender, young-female patients had a median-OS of 5 versus 11 months for young-man (P=0.001). Conclusions This is one of the pioneer studies correlating age with gender and the prognostic features of bad prognosis in Latin-American population. Besides, supports the idea that a global effort is required to improve awareness, prevention, and early diagnosis of GC.

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Latin American young patients with gastric adenocarcinoma: worst prognosis and outcomes

Calderillo-Ruíz,

Díaz-Romero,

Carbajal-López

et al. 2023

J Gastrointest Oncol

View full text Add to dashboard Cite

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Risk of early death in adolescents and young adults with cancer: a population-based study

Berkman

Andersen

Hildebrandt

et al. 2023

JNCI: Journal of the National Cancer Institute

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Background Advancements in treatment and supportive care have led to improved survival for adolescents and young adults (AYAs) with cancer; however, a subset of those diagnosed remain at risk for early death (within 2 months of diagnosis). Factors that place AYAs at increased risk of early death have not been well studied. Methods The Surveillance, Epidemiology, and End Results registry was used to assess risk of early death in AYAs with hematologic malignancies, central nervous system tumors, and solid tumors. Associations between age at diagnosis, sex, race, ethnicity, socioeconomic status, insurance status, rurality, and early death were assessed. Results A total of 268 501 AYAs diagnosed between 2000 and 2016 were included. Early death percentage was highest in patients diagnosed with hematologic malignancies (3.1%, 95% confidence interval [CI] = 2.9% to 3.2%), followed by central nervous system tumors (2.5%, 95% CI = 2.3% to 2.8%), and solid tumors (1.0%, 95% CI = 0.9% to 1.0%). Age at diagnosis, race, ethnicity, lower socioeconomic status, and insurance status were associated with increased risk of early death in each of the cancer types. For AYAs with hematologic malignancies and solid tumors, risk of early death decreased statistically significantly over time. Conclusions A subset of AYAs with cancer remains at risk for early death. In addition to cancer type, sociodemographic factors also affect risk of early death. A better understanding of the interplay of factors related to cancer type, treatment, and health systems that place certain AYA subsets at higher risk for early death is needed to address these disparities and improve outcomes.

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1468P Characteristics and prognosis of gastric cancer (GC) in adolescents and young adults (AYA) in Singapore

Cited by 2 publications

References 0 publications

Latin American young patients with gastric adenocarcinoma: worst prognosis and outcomes

Latin American young patients with gastric adenocarcinoma: worst prognosis and outcomes

Risk of early death in adolescents and young adults with cancer: a population-based study

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