149P Clinical implications of serum mi-RNA -155 and mi-RNA- 92a in diffuse large B cell lymphoma

Abstract

Results: Alpha diversity was higher in non-metastasis cohort than that in metastasis cohort, but no significance (observed species P ¼ 0.08, and Shannon index P ¼ 0.03). Beta diversity was higher in non-metastasis cohort than that in metastasis cohort significantly (weighted unifrac p<0.01). Compared to non-metastasis cohort, the relative abundance rate of familie verrucomicrobia (metastasis cohort 0.056 and nonmetastasis cohort 0.022, p<0.05) was greater in metastasis cohort, of which Akkermansia muciniphila (metastasis cohort 0.057 and non-metastasis cohort 0.023, p<0.05) was significantly different between the two cohorts. Conclusions:We demonstrated, for the first time, a potential relationship between the microbe Akkermansia muciniphila in lung adenocarcinoma tissues and lymph node metastasis in lung adenocarcinoma, which needs to be confirmed in a larger study.