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Adams, Nicholas W. H.; Kramer, James R.

doi:10.1023/a:1009699617808

Cited by 71 publications

(23 citation statements)

References 10 publications

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“…61 The database file minteq.v4.dat of the software 61 was used for the calculations since some amino acids and other organic components were already included in this database. Modifications to the database were applied to account for the complexation equilibria of cysteine with silver ions 13,62 and with the test media components magnesium, calcium, manganese, copper, zinc, iron and cobalt using the NIST standard database 46.8, 63 and data of Berthon et al 64 and Goldberg et al 65 The data for Ag + -cysteine binding were also used to describe the binding of Ag + to Table 1 Main components of the test media and durations of the tests, important reducing agents are marked in bold and oxidising agents are marked in italics. Ionic strengths were calculated using the software PHREEQCi (v.3).…”

Section: Numerical Speciationmentioning

confidence: 99%

Predictability of silver nanoparticle speciation and toxicity in ecotoxicological media

Köser

Engelke

Hoppe

et al. 2017

Environ. Sci.: Nano

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Section: Numerical Speciationmentioning

confidence: 99%

Predictability of silver nanoparticle speciation and toxicity in ecotoxicological media

Köser

Engelke

Hoppe

et al. 2017

Environ. Sci.: Nano

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“…Cysteine has three functional groups: NH 2 , C(O)OH, and SH, which can coordinate metal ions and produce metal complexes. [49][50][51] Since the concentrations of reagents used for CSS are within the range where Ag-thiol complexes prevail due to the high affinity of thiols for silver, 52 thiol groups are coordinated by metal ions. This leads to the formation of SM zwitterions.…”

Section: Model Of Gelation In Cssmentioning

confidence: 99%

Mechanism of gelation in low-concentration aqueous solutions of silver nitrate with l-cysteine and its derivatives

et al. 2017

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We discuss the results of experimental studies of the processes of gelation in aqueous solutions of silver nitrate with l-cysteine and its derivatives. We focus on understanding what determines if these small molecules will self-assemble in water at their extremely low concentration to form a gel. A mechanism of gel formation in a cysteine-silver solution (CSS) is proposed. The analysis of the results indicates that filamentary aggregates of a gel network are formed via interaction of NH and C(O)O groups that belong to neighboring silver mercaptide (SM) aggregates. In turn, formation of sulphur-silver bonds between silver mercaptide molecules is responsible for self-assembling these molecules into SM aggregates which can be considered as supramonomers. Free polar groups located on the surfaces of the aggregates can form hydrogen bonds with water molecules, which explains the unique ability of CSS hydrogels to trap water at low concentrations of low-molecular-weight hydrogelators.

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“…The binding of thiols to AuNP surfaces has been well investigated [51–57]. As the most abundant intracellular biothiols are cysteine (CYS) and glutathione (GSH), their role in intracellular sulfidation and/or adsorption on the surface of NPs should be considered during the evaluation of efficacy, safety and behavior of AgNPs and AuNPs in vivo [47,58]. The biological effects of GSH-coated AuNPs and the potential for their biomedical use have been assessed [55–57].…”

Section: Introductionmentioning

confidence: 99%

Toxicity and safety study of silver and gold nanoparticles functionalized with cysteine and glutathione

Pem¹,

Pongrac²,

Ulm³

et al. 2019

Beilstein J. Nanotechnol.

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This study was designed to evaluate the nano–bio interactions between endogenous biothiols (cysteine and glutathione) with biomedically relevant, metallic nanoparticles (silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs)), in order to assess the biocompatibility and fate of nanoparticles in biological systems. A systematic and comprehensive analysis revealed that the preparation of AgNPs and AuNPs in the presence of biothiols leads to nanoparticles stabilized with oxidized forms of biothiols. Their safety was tested by evaluation of cell viability, reactive oxygen species (ROS) production, apoptosis induction and DNA damage in murine fibroblast cells (L929), while ecotoxicity was tested using the aquatic model organism Daphnia magna. The toxicity of these nanoparticles was considerably lower compared to their ionic metal forms (i.e., Ag+ and Au3+). The comparison with data published on polymer-coated nanoparticles evidenced that surface modification with biothiols made them safer for the biological environment. In vitro evaluation on human cells demonstrated that the toxicity of AgNPs and AuNPs prepared in the presence of cysteine was similar to the polymer-based nanoparticles with the same core material, while the use of glutathione for nanoparticle stabilization was considerably less toxic. These results represent a significant contribution to understanding the role of biothiols on the fate and behavior of metal-based nanomaterials.

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Cited by 71 publications

References 10 publications

Predictability of silver nanoparticle speciation and toxicity in ecotoxicological media

Predictability of silver nanoparticle speciation and toxicity in ecotoxicological media

Mechanism of gelation in low-concentration aqueous solutions of silver nitrate with l-cysteine and its derivatives

Toxicity and safety study of silver and gold nanoparticles functionalized with cysteine and glutathione

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