Untitled

Synthesis and anti-bacterial screening of ethyl 6-oxo-3-phenyl-1,6-dihydropyrano[3,2-e]indole-2-carboxylate and 7-phenyl-5H-pyrano [3′,2′:4,5]indolo[1,2-a]quinoxaline-6,10-dione

“…[13][14][15][16][17] The result of the variety of the physiological activity of pyrroloindole derivatives [18][19] and also the possibility of their use in the synthesis of alkaloids and alkaloid related substances. We report here the synthesis of quinoxalin-6,10-dione 5a-c from ethyl 1-(2-nitrophenyl)-6-oxo-3-phenyl-1,6-dihydropyrano [3,2-e] indole-2-carboxylate 4a-c.…”

“…Coumarins constitute an important class of naturally occurring compounds with useful pharmacological activity [1][2][3][4][5][6] as antibacterial [7][8][9][10][11][12] and antifungal agents. [13][14][15][16][17] The result of the variety of the physiological activity of pyrroloindole derivatives [18][19] and also the possibility of their use in the synthesis of alkaloids and alkaloid related substances. We report here the synthesis of quinoxalin-6,10-dione 5a-c from ethyl 1-(2-nitrophenyl)-6-oxo-3-phenyl-1,6-dihydropyrano [3,2- N-Nitroarylation of carboxylates 3a-c was achieved via Ullamann reaction [20][21] by refluxing pyranoindole-2-carboxylate 3a-c with 2-choronitrobenzene using anhydrous K 2 CO 3 and cupric oxide in dry pyridine to afford ethyl…”