14C-Eugenol: I. Synthesis, Polymerization, and Use

Weinberg, Jacob E.; Rabinowitz, Joseph L.; Zanger, Murray; Gennaro, Alfonso R.

doi:10.1177/00220345720510041101

Cited by 26 publications

(5 citation statements)

References 12 publications

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“…Historically eugenol has been used to treat dental problems due to its analgesic, anesthetic, anti-inflammatory and antibacterial effects 41 42 . Previous studies have shown that eugenol is absorbed into the tissues of rats, including the intestine 43 44 . Given this, we appreciate the possibility that the effects we describe of diet supplementation with eugenol may be a direct interaction with intestinal tissue stimulating mucus secretion, independent of the microbial changes we characterize.…”

Section: Discussionmentioning

confidence: 99%

Phytonutrient diet supplementation promotes beneficial Clostridia species and intestinal mucus secretion resulting in protection against enteric infection

Wlodarska

Willing

Bravo³

et al. 2015

Sci Rep

137

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Plant extracts, or phytonutrients, are used in traditional medicine practices as supplements to enhance the immune system and gain resistance to various infectious diseases and are used in animal production as health promoting feed additives. To date, there are no studies that have assessed their mechanism of action and ability to alter mucosal immune responses in the intestine. We characterized the immunomodulatory function of six phytonutrients: anethol, carvacrol, cinnamaldehyde, eugenol, capsicum oleoresin and garlic extract. Mice were treated with each phytonutrient to assess changes to colonic gene expression and mucus production. All six phytonutrients showed variable changes in expression of innate immune genes in the colon. However only eugenol stimulated production of the inner mucus layer, a key mucosal barrier to microbes. The mechanism by which eugenol causes mucus layer thickening likely involves microbial stimulation as analysis of the intestinal microbiota composition showed eugenol treatment led to an increase in abundance of specific families within the Clostridiales order. Further, eugenol treatment confers colonization resistance to the enteric pathogen Citrobacter rodentium. These results suggest that eugenol acts to strengthen the mucosal barrier by increasing the thickness of the inner mucus layer, which protects against invading pathogens and disease.

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Section: Discussionmentioning

confidence: 99%

Phytonutrient diet supplementation promotes beneficial Clostridia species and intestinal mucus secretion resulting in protection against enteric infection

Wlodarska

Willing

Bravo³

et al. 2015

Sci Rep

137

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“…29 Even after the end of the setting reaction, eugenol release leads to selfoxidation and becomes darker with time. 30 Moreover, ZOE sealers present increased solubility. 31,32 This type of crown discoloration has been characterized as chemical discoloration.…”

Section: Discussionmentioning

confidence: 99%

Crown Discoloration Induced by Endodontic Sealers: Spectrophotometric Measurement of Commission International de I'Eclairage's L, a, b* Chromatic Parameters

Ioannidis

Beltes

Lambrianidis

et al. 2013

Operative Dentistry

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This study emphasizes the need for attention after root canal obturation. The prevention of tooth staining post-operatively is still a clinical issue that affects patients and dentists. Clinicians must be able to recognize the etiology of local intrinsic staining and even in cases of sealer-induced discoloration must be able diagnose the type of sealer that was used. The prevention of crown discoloration in endodontically-treated teeth is currently taught in all accredited graduate and post-graduate programs. ABSTRACTDespite the improvement of endodontic materials, crown discoloration induced by root *Konstantinos Ioannidis, DDS, MSc in Endodontology, specialist in Endodontics (GDC,

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“…Free or even bound eugenol changes chemically (oxidizes) and darkens with time. [1023] Although AH Plus is silver-free and advertised as nonstaining compared to its predecessor AH26, it caused more overall coronal discoloration (grayish discoloration) than Apexit Plus sealer (reddish brown discoloration). Some authors found the same results but with AH26 sealer.…”

Section: Discussionmentioning

confidence: 99%

Coronal discoloration effect of three endodontic sealers: An in vitro spectrophotometric analysis

Sayed

Etemadi

2013

J Conserv Dent

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Aim:This in vitro study compared the coronal discoloration effect of three endodontic sealers at short-time intervals.Materials and Methods:The crowns of 50 extracted premolars were cut and their pulp chambers were cleaned and randomly divided into five groups (n = 10). The following materials were placed into the pulp chambers: Group I: AH Plus, group II: Apexit Plus, group III: Sultan, group IV: Amalgam, and group V: Distilled water. The color of the crowns was measured using Shadepilot™ spectrophotometer (DeguDent, Hanau, Germany) prior and after the placement of experimental materials within pulp chambers. Color changes (ΔE values) and shades were recorded in 3, 10, and 17 days. A Kruskal-Wallis and Mann-Whitney tests were used to assess significant differences between the sealers. Wilcoxon test was used to compare color changes at different periods within each group.Results:All sealers showed significant discoloration effect that increased over the time. At the end of the observation period, Apexit Plus showed the lowest coronal discoloration effect (ΔE = 6.38 ± 0.55).Conclusions:All sealers used in the current study may cause a progressive coronal discoloration effect over 10-17 days. Apexit Plus sealer showed the lowest coronal discoloration effect.

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14C-Eugenol: I. Synthesis, Polymerization, and Use

Cited by 26 publications

References 12 publications

Phytonutrient diet supplementation promotes beneficial Clostridia species and intestinal mucus secretion resulting in protection against enteric infection

Phytonutrient diet supplementation promotes beneficial Clostridia species and intestinal mucus secretion resulting in protection against enteric infection

Crown Discoloration Induced by Endodontic Sealers: Spectrophotometric Measurement of Commission International de I'Eclairage's L, a, b* Chromatic Parameters

Coronal discoloration effect of three endodontic sealers: An in vitro spectrophotometric analysis

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14C-Eugenol: I. Synthesis, Polymerization, and Use

Cited by 26 publications

References 12 publications

Phytonutrient diet supplementation promotes beneficial Clostridia species and intestinal mucus secretion resulting in protection against enteric infection

Phytonutrient diet supplementation promotes beneficial Clostridia species and intestinal mucus secretion resulting in protection against enteric infection

Crown Discoloration Induced by Endodontic Sealers: Spectrophotometric Measurement of Commission International de I'Eclairage's L*, a*, b* Chromatic Parameters

Coronal discoloration effect of three endodontic sealers: An in vitro spectrophotometric analysis

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Product

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Crown Discoloration Induced by Endodontic Sealers: Spectrophotometric Measurement of Commission International de I'Eclairage's L, a, b* Chromatic Parameters