15-Epi-lipoxin A4 inhibits the progression of endometriosis in a murine model

Chen, Qionghua; Zhou, Weidong; Pu, Demin; Huang, Qiansheng; Tian, Li; Chen, Qing‐Xi

doi:10.1016/j.fertnstert.2009.01.107

Cited by 24 publications

(27 citation statements)

References 33 publications

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“…Values shown are the mean ± SEM. *p<0.01 versus sham and #p<0.01 versus MCAO MMP-9 activity and mRNA expression in a murine model of endometriosis (Chen et al 2010). In addition, ATL-1, an analog of aspirin-triggered LXA 4 , attenuated MMP-9 increases induced by vascular endothelial growth factor in endothelial cells (Cezar-de-Mello et al 2008).…”

Section: Discussionmentioning

confidence: 99%

A Lipoxin A4 Analog Ameliorates Blood–Brain Barrier Dysfunction and Reduces MMP-9 Expression in a Rat Model of Focal Cerebral Ischemia–Reperfusion Injury

Wang

Guo

et al. 2011

J Mol Neurosci

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LXA(4) methyl ester (LXA(4)ME), a lipoxin A(4) analog, reduces ischemic insult in the rat models of transient or permanent cerebral ischemic injury. We investigated whether LXA(4)ME could ameliorate blood-brain barrier (BBB) dysfunction after stroke by reducing matrix metalloproteinase (MMP)-9 expression. Adult male rats were subjected to 2-h middle cerebral artery occlusion (MCAO) followed by 24-h reperfusion. Brain infarctions were detected by triphenyltetrazolium chloride (TTC) staining. BBB dysfunction was determined by examining brain edema and Evans Blue extravasation. Temporal expression of MMP-9 was determined by zymography and Western blot. The presence of tissue inhibitors of metalloproteinase-1 (TIMP-1) was also determined by Western blot in tissue protein sample. Brain edema and Evans Blue leakage were significantly reduced after stroke in the LXA(4)ME group and were associated with reduced brain infarct volumes. MMP-9 activity and expression were inhibited by LXA(4)ME after stroke. In addition, LXA(4)ME significantly increased TIMP-1 protein levels. Our results indicate that LXA(4)ME reduces brain injury by improving BBB function in a rat model of MCAO, and that a relationship exists between BBB permeability and MMP-9 expression following ischemic insult. Furthermore, these results suggest that LXA(4)ME-mediated reduction of MMP-9 following stroke are attributed to increased TIMP-1 expression.

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Section: Discussionmentioning

confidence: 99%

A Lipoxin A4 Analog Ameliorates Blood–Brain Barrier Dysfunction and Reduces MMP-9 Expression in a Rat Model of Focal Cerebral Ischemia–Reperfusion Injury

Wang

Guo

et al. 2011

J Mol Neurosci

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“…Direct evidence for the therapeutic potential of resolution mediators is provided by the demonstration that endometriosis progression in a mouse model was inhibited by exogenous ATL administration (Chen et al 2009). This was accompanied by decreased pro-inflammatory cytokine formation as well as reduced lesion production of MMP2 and MMP9 (Chen et al 2010b). The effects of lipoxins on endothelial cell function may also be relevant, since angiogenesis is a known feature of endometriosis.…”

Section: Menstrual Functionmentioning

confidence: 96%

Molecular regulators of resolution of inflammation: potential therapeutic targets in the reproductive system

Hutchinson

Rajagopal²,

Sales³

et al. 2011

Reproduction

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Inflammatory processes are central to reproductive events including ovulation, menstruation, implantation and labour, while inflammatory dysregulation is a feature of numerous reproductive pathologies. In recent years, there has been much research into the endogenous mechanisms by which inflammatory reactions are terminated and tissue homoeostasis is restored, a process termed resolution. The identification and characterisation of naturally occurring pro-resolution mediators including lipoxins and annexin A1 has prompted a shift in the field of anti-inflammation whereby resolution is now observed as an active process, triggered as part of a normal inflammatory response. This review will address the process of resolution, discuss available evidence for expression of pro-resolution factors in the reproductive tract and explore possible roles for resolution in physiological reproductive processes and associated pathologies. Reproduction (2011) 142 15-28

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“…116,117 It is noteworthy that LXA 4 and its analogs decrease MMP expression and activity in many different cell types 118,119 and also in peritoneal fluid cells in a mouse model of endometriosis, 120,121 of which macrophages comprise a major component.…”

Section: Macrophages As a Lxa4 Targetmentioning

confidence: 99%

The role of Lipoxin A4 in endometrial biology and endometriosis

Canny

Lessey

2013

Mucosal Immunology

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Lipoxin A4 (LXA4), an endogenous anti-inflammatory and immunomodulatory mediator studied in many disease states, is recently appreciated as a potentially significant player in the endometrium. This eicosanoid, synthesized from arachidonic acid via the action of lipoxygenase enzymes, is likely regulated in endometrial tissue during the menstrual cycle. Recent studies revealed that LXA4 acts as an estrogen receptor agonist in endometrial epithelial cells, antagonizing some estrogen-mediated activities in a manner similar to the weak estrogen estriol, with which it shares structural similarity. LXA4 may also be an anti-inflammatory molecule in the endometrium, though its precise function in various physiological and pathological scenarios remains to be determined. The expression patterns for LXA4 and its receptor in the female reproductive tract suggest a role in pregnancy. The present review provides an oversight of its known and putative roles in the context of immuno-endocrine crosstalk. Endometriosis, a common inflammatory condition and a major cause of infertility and pain, is currently treated by surgery or anti-hormone therapies that are contraceptive and associated with undesirable side effects. LXA4 may represent a potential therapeutic and further research to elucidate its function in endometrial tissue and the peritoneal cavity will undoubtedly provide valuable insights.

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15-Epi-lipoxin A4 inhibits the progression of endometriosis in a murine model

Cited by 24 publications

References 33 publications

A Lipoxin A4 Analog Ameliorates Blood–Brain Barrier Dysfunction and Reduces MMP-9 Expression in a Rat Model of Focal Cerebral Ischemia–Reperfusion Injury

A Lipoxin A4 Analog Ameliorates Blood–Brain Barrier Dysfunction and Reduces MMP-9 Expression in a Rat Model of Focal Cerebral Ischemia–Reperfusion Injury

Molecular regulators of resolution of inflammation: potential therapeutic targets in the reproductive system

The role of Lipoxin A4 in endometrial biology and endometriosis

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