15-Ketodihydro-PGF2α and cortisol plasma concentrations in newborn foals after spontaneous or oxytocin-induced parturition

Panzani, S.; Villani, M.; Govoni, Nadia; Kindahl, H.; Faustini, M.; Romano, G.; Veronesi, M.C.

doi:10.1016/j.theriogenology.2008.09.053

Cited by 10 publications

(18 citation statements)

References 23 publications

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“…The cortisol concentrations found in the present study were higher than the values reported for the plasma of full--term foals at birth and 30 minutes (Silver et al 1991, Panzani et al 2009), and in another study realized in foals fur, at birth (Comin et al 2012). It is well known that, during the first few hours after parturition, newborns have high cortisol levels in response to the stress of labor, birth, and adaptation to extrauterine life (Elverson & Wilson 2005).…”

Section: Discussioncontrasting

confidence: 62%

“…These results differed from values reported in foals also born from natural delivery (Panzani et al 2009) but were similar to those reported for newborn foals at the same periods of evaluation (Comin et al 2012). The variation observed between the analyzed time points corresponds to the period of adaptation to extra--uterine life, where spontaneous breathing and adjustment of the cardiocirculatory and respiratory systems, among other functions previously performed by the placenta, are established.…”

Section: Discussionsupporting

confidence: 59%

“…The stimulation of the hypothalamic-pituitary-adrenal (HPA) axis and increased cortisol concentrations in fetal plasma are associated with neonatal maturity, viability, and adaptation to independent life in horses (Panzani et al 2009). In order to evaluate the longer-duration of dynamic changes in cortisol secretion attributed to stress responses and to avoid stress caused by repeated blood collections some authors establish the determination of cortisol through salivary analysis (Nagel et al 2015), assessment of fur cortisol concentrations in foals (Montillo et al 2014), calculation of average daily cortisol concentrations via an indwelling catheter (Malarkey et al 1995), or measurement of fecal cortisol metabolites (Schmidt et al 2010).…”

Section: Discussionmentioning

confidence: 99%

“…In calves, the opposite effect on plasma cortisol levels is observed, and the release of catecholamines during delivery can increase and then decrease after birth (Aurich et al 1993). Cortisol concentrations were the highest in the first 4 hours of life (Rossdale et al 1984), which corresponds to the period of adaptation to extrauterine life and the stress caused by labor (Panzani et al 2009, Elverson & Wilson 2005; therefore, cortisol analysis should not be considered the only method to evaluate the health of the newborn. Other health evaluations are recommended.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of neonatal vitality and blood glucose, lactate and cortisol concentrations in foals of the Paint Horse breed

et al. 2017

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RESUMO.-[Avaliação dos padrões de vitalidade neonatal, glicemia, lactato e cortisol em potros da raça PaintHorse.] A avaliação clínica dos recém-nascidos, bem como a definição da conduta terapêutica adotada representam expressivos desafios ao Médico Veterinário. O objetivo deste estudo foi avaliar a vitalidade neonatal pelo escore de Apgar modificado, glicemia, lactatemia e cortisol em neonatos equinos. Para tal, foram utilizados 20 potros da raça Paint Horse, nascidos em eutocia, durante as primeiras 48 horas de vida. O escore de Apgar modificado foi realizado ao nascimento e 10 minutos após, atribuindo-se notas de 0 a 10. As colheitas das amostras de sangue, para a realização das análises laboratoriais, ocorreram nos momentos ao nascimento, 4, 8, 12, 20 16, 20, 24, 36 Clinical evaluations of newborns, as well as defining the therapeutic decision, represent significant challenges to the veterinarian. This study aimed to evaluate neonatal vitality using the modified Apgar score and blood glucose, lactate, and cortisol concentrations in newborn equines. Twenty foals of the Paint Horse breed born by normal delivery were evaluated during the first 48 hours of life. The modified Apgar score was determined at birth and 10 minutes later, with values ranging from 0 to 10. Blood samples for the laboratory tests were collected at birth and at 4, 8, 12, 16, 20, 24, 36, and 48 hours. The mean Apgar score was significantly lower at birth than at 10 minutes (p < 0.001). Blood glucose concentrations increased significantly between birth (98.90 ± 35.97 mg/dL) and 8 hours (127.90 ± 27.15 mg/dL), stabilizing after the first 12 hours (148.95 ± 29.59 mg/dL). Serum lactate concentrations showed a significant decrease across the time points tested, with the highest value occurring at birth (5.48 ± 2.17 mmol/L) and stabilizing after 24 hours (2.76 ± 1.31 mmol/L). Cortisol concentrations significantly decreased (p < 0.01) between 4 (10.46 ± 7.46 µg/dL) and 48 hours (5.21 ± 3.35 µg/dL), with the highest value occurring 4 hours after birth. The common occurrence of laboratory abnormalities in healthy newborn foals reinforces the need to conduct regular clinical examinations and to develop laboratory reference values for different breeds and ages.INDEX TERMS: Neonate equine, apgar score, lactatemia, glycemia, neonatal stress.

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Section: Discussioncontrasting

confidence: 62%

Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Evaluation of neonatal vitality and blood glucose, lactate and cortisol concentrations in foals of the Paint Horse breed

et al. 2017

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“…Among these, the prostaglandins (PGs) play a major role during parturition and in the final multi‐system maturational processes of the newborn, but their exact pattern is poorly understood (Skinner and Challis 1985; Challis et al. 1997; Ousey 2004, 2006; Panzani et al. 2009).…”

Section: Introductionmentioning

confidence: 99%

Comparative Study on 15‐Ketodihydro‐PGF_2α Plasma Concentrations in Newborn Horses, Donkeys and Calves

Panzani¹,

Carluccio²,

Probo³

et al. 2011

Reprod Domestic Animals

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The aim of this study was to compare the plasma profiles of 15-ketodihydro-PGF(2α) (PGM) in healthy neonates of three different species from birth until the third week of life. Twenty-four horse foals, 12 donkey foals, and 9 calves were studied. Blood samples were collected at 10, 20 and 30 min after birth, at 3, 24 and 72 h after birth, and at 7, 10, 17 and 21 days of life. All mothers experienced normal gestation lengths and normal, spontaneous deliveries. All newborns were judged mature and viable. Hormone concentrations were higher (p < 0.05) in horse foals 20 and 30 min after birth compared to later samples, and at 10 min in donkey foals compared to later samples (p < 0.05). In calves, higher (p < 0.05) concentrations of PGM were observed 10, 20, 30 min and 3 hours from parturition compared to later samples. These findings may be related to increased fetal placental unit production during parturition, while the relatively high PGF(2α) levels in the days after parturition may be connected with their role in completing organ maturation. Despite the existing differences between these species, the statistical analysis did not discover significant differences in PGM profiles during the first 3 weeks of life in donkey, horse and cattle newborns. The low levels observed 10 days after birth are possibly due to a fast completion of maturational development in these species.

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Induction of parturition in horses – from physiological pathways to clinical applications

Nagel¹,

Aurich

2022

Domestic Animal Endocrinology

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15-Ketodihydro-PGF2α and cortisol plasma concentrations in newborn foals after spontaneous or oxytocin-induced parturition

Cited by 10 publications

References 23 publications

Evaluation of neonatal vitality and blood glucose, lactate and cortisol concentrations in foals of the Paint Horse breed

Evaluation of neonatal vitality and blood glucose, lactate and cortisol concentrations in foals of the Paint Horse breed

Comparative Study on 15‐Ketodihydro‐PGF_2α Plasma Concentrations in Newborn Horses, Donkeys and Calves

Induction of parturition in horses – from physiological pathways to clinical applications

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15-Ketodihydro-PGF2α and cortisol plasma concentrations in newborn foals after spontaneous or oxytocin-induced parturition

Cited by 10 publications

References 23 publications

Evaluation of neonatal vitality and blood glucose, lactate and cortisol concentrations in foals of the Paint Horse breed

Evaluation of neonatal vitality and blood glucose, lactate and cortisol concentrations in foals of the Paint Horse breed

Comparative Study on 15‐Ketodihydro‐PGF2α Plasma Concentrations in Newborn Horses, Donkeys and Calves

Induction of parturition in horses – from physiological pathways to clinical applications

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Product

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Comparative Study on 15‐Ketodihydro‐PGF_2α Plasma Concentrations in Newborn Horses, Donkeys and Calves