2014
DOI: 10.1002/cam4.222
|View full text |Cite
|
Sign up to set email alerts
|

15‐LOX‐1 suppression of hypoxia‐induced metastatic phenotype and HIF‐1α expression in human colon cancer cells

Abstract: The expression of 15-lipoxygenase-1 (15-LOX-1) is downregulated in colon cancer and other major cancers, and 15-LOX-1 reexpression in cancer cells suppresses colonic tumorigenesis. Various lines of evidence indicate that 15-LOX-1 expression suppresses premetastatic stages of colonic tumorigenesis; nevertheless, the role of 15-LOX-1 loss of expression in cancer epithelial cells in metastases continues to be debated. Hypoxia, a common feature of the cancer microenvironment, promotes prometastatic mechanisms such… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

1
20
0

Year Published

2015
2015
2023
2023

Publication Types

Select...
5
1

Relationship

0
6

Authors

Journals

citations
Cited by 19 publications
(21 citation statements)
references
References 62 publications
1
20
0
Order By: Relevance
“…Reexpression of 15-LOX-1 in CRC cells significantly downregulates HIF1α mRNA expression and affects HIF1α protein levels by enhancing the degradation of HIF1α under hypoxic conditions. This process leads to decreased VEGF expression, reduced cell migration and invasion [141]. Celecoxib treatment of CRC cells markedly upregulates the expression of 15-LOX-1 (Table 1) and induces apoptosis in CRC cells [118].…”
Section: Enzyme Inhibitionmentioning
confidence: 99%
“…Reexpression of 15-LOX-1 in CRC cells significantly downregulates HIF1α mRNA expression and affects HIF1α protein levels by enhancing the degradation of HIF1α under hypoxic conditions. This process leads to decreased VEGF expression, reduced cell migration and invasion [141]. Celecoxib treatment of CRC cells markedly upregulates the expression of 15-LOX-1 (Table 1) and induces apoptosis in CRC cells [118].…”
Section: Enzyme Inhibitionmentioning
confidence: 99%
“…15-LOX-1 overexpression in cells leads to an enhanced production of 13(S)-HODE from the substrate linoleic acid. This bioactive lipid has previously been shown to affect endothelial cell characteristics in models of atherosclerosis [34] as well as cancer [12]. Incubation of HUVECs with a 1:1 mixture of ECM and complete RPMI-1640 containing 25 μM 13(S)-HODE led to reduced motility in a scratch wound assay ( Fig.…”
Section: Incubation Of Ec's With 13(s)-hode Phenocopied Most But Notmentioning
confidence: 83%
“…15-LOX-1 expression is widely suppressed in CRC, primarily through epigenetic mechanisms [2]. Re-expression of the protein in different cancer models has been shown to negate several hallmarks of cancer, including angiogenesis [38,39]. Here, we aimed to understand the mechanism through which 15-LOX-1 re-expression in CRC cell lines inhibited angiogenesis in endothelial cells.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…4A). In addition to being a key redox enzyme in oxidative stress-related cell death, 12/15-LOX has also been shown to regulate HIF1 and induce VEGF [37, 38]. Comparison of one of the best flavones, 3’,4’-dihydroxyflavone to NDGA and FG-4592, a HIF PHD inhibitor developed by Fibrogen (Fig.…”
Section: Methodsmentioning
confidence: 99%