15. Predictors of recurrent spontaneous bacterial peritonitis in patients with cirrhosis of liver

Nair, Sandeep V

doi:10.1016/j.jceh.2018.06.376

Cited by 2 publications

(8 citation statements)

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“…Among these patients, 89 survived and 38 had a recurrence (42.7%). Similar results were obtained in the unicentric prospective study of Nair et al published in 2018 where a recurrence of SBP was noted in 40.5% of patients [ 10 ]. A lower prevalence of recurrent SBP was observed in the study of Marciano et al published in 2019, which included 115 patients with cirrhosis who survived a first SBP episode and who were on norfloxacin antibiotic prophylaxis [ 11 ].…”

Section: Discussionsupporting

confidence: 88%

“…In the study published in 2018 by Nair et al , the presence of fever on admission, hepatic encephalopathy, diuretics, antibiotic prophylaxis, recent use of antibiotics (<30 days), iterative large-volume paracentesis, Child Pugh score C and presence of HTG were significantly associated with recurrent SBP [ 10 ]. In multivariate analysis, HTG was an independent factor of SBP recurrence (p = 0.001) which consolidates the results of our study: Indeed, both the presence of HTG and gastric varices were identified as independent predictive factors of SBP recurrence.…”

Section: Discussionmentioning

confidence: 99%

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Predictive Factors of Recurrence in Spontaneous Bacterial Peritonitis in Tunisian Patients With Cirrhosis

et al. 2023

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Introduction: Recurrent spontaneous bacterial peritonitis (SBP) in patients with cirrhosis is associated with poor prognosis. Aim: To assess the prevalence and the risk factors for recurrence and to evaluate its impact on the prognosis. Materials & methods: We conducted a retrospective study including patients with cirrhosis having a first episode of SBP. Results: A recurrence of SBP was identified in 43.4% of the patients who survived after a first episode of SBP. The mean time to onset of the first SBP recurrence from the first episode was 32 days. Recurrence factors were endoscopic hypertensive signs, a positive ascites culture, diarrhea and the MELD score. Conclusion: There was no impact on survival of recurrent SBP compared with the first SBP episode.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Predictive Factors of Recurrence in Spontaneous Bacterial Peritonitis in Tunisian Patients With Cirrhosis

et al. 2023

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“…Studies with larger populations are necessary to detect further differences with statistical significance. Nonetheless, our population size in a five-year period is comparable with other published literature assessing patients with SBP [ 10 , 11 , 24 – 29 ]. Karvellas et al [ 11 ] analyzed aspects of antimicrobial therapy to mortality in patients with SBP from an international multicenter database over a 15-year time span, yielding a cohort of 126 patients.…”

Section: Discussionsupporting

confidence: 80%

“…Multiple studies have shown the recurrence rate of SBP in patients with previous episodes is > 40% [ 22 , 23 ]. Given that a prior documented history did not affect the timing of paracentesis is another troublesome finding as recurrence of SBP is known to be associated with higher mortality [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…Karvellas et al [ 11 ] analyzed aspects of antimicrobial therapy to mortality in patients with SBP from an international multicenter database over a 15-year time span, yielding a cohort of 126 patients. In three studies assessing factors associated with recurrence of SBP, 139 patients over a 4-year period, 124 patients over a 3-year period, and 111 patients in a 1-year analysis have contributed to practice changing results [ 22 , 24 , 27 ]. In addition, other studies of patients with SBP have shown in-hospital mortality rates of 37–81%, which encompass similar results to our cohort, allowing generalizability to other populations with SBP [ 10 , 11 , 13 , 27 – 29 ].…”

Section: Discussionmentioning

confidence: 99%

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Factors Associated with Delayed Paracentesis in Patients with Spontaneous Bacterial Peritonitis

et al. 2020

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Background and Aim In patients with spontaneous bacterial peritonitis (SBP), studies show that delayed paracentesis (DP) is associated with worse outcomes and mortality. We aimed to assess the rate of DP in the community setting and associated factors with early versus delayed paracentesis. Methods Patients hospitalized with SBP were retrospectively studied between 12/2013 and 12/2018. DP was defined as paracentesis performed > 12 h from initial encounter. Data collected included: patient factors (i.e., age, race, symptoms, history of SBP, MELD) and physician factors (i.e., admission service, shift times, providers ordering and performing paracentesis). Logistic regression analysis was performed to assess for factors associated with DP. Results DP occurred 82% of the time ( n = 97). The most significant factors in predicting timing of paracentesis were ordering physician [emergency department (ED) physician was associated with early paracentesis (57% vs 8%, p < 0.001) and specialty of physician performing paracentesis (interventional radiology was associated with DP (88% vs 48%, p < 0.001)]. Younger patients were more likely to receive early paracentesis. In regression analysis, the factor most associated with early paracentesis was when the order was made by the ED provider (OR 0.07, 95% CI 0.02–0.22). No differences were observed in patients with prior history of SBP, abdominal pain, encephalopathy, or creatinine level. Conclusions Studies have suggested that DP is associated with increased mortality in patients with SBP. Despite this, DP is common in the community setting and is influenced by ordering physician and specialty of physician performing paracentesis. Future efforts should assess interventions to improve this important quality indicator.

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15. Predictors of recurrent spontaneous bacterial peritonitis in patients with cirrhosis of liver

Cited by 2 publications

References 0 publications

Predictive Factors of Recurrence in Spontaneous Bacterial Peritonitis in Tunisian Patients With Cirrhosis

Predictive Factors of Recurrence in Spontaneous Bacterial Peritonitis in Tunisian Patients With Cirrhosis

Factors Associated with Delayed Paracentesis in Patients with Spontaneous Bacterial Peritonitis

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