15-Year lipid profile effects on cardiovascular events adjusted for cardiovascular risk factors: a cohort study from Middle-East

Sadeghi, Masoumeh; Golshahi, Jafar; Talaei, Mohammad; Sheikhbahaei, Erfan; Ghodjani, Erfan; Mansouri, M R; Mansouri, Pejman; Sarrafzadegan, Nizal; Roohafza, Hamidreza

doi:10.1080/00015385.2020.1717096

Cited by 10 publications

(5 citation statements)

References 24 publications

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“…Cardiovascular disease is the primary cause of morbidity and mortality globally. Patients with Coronary artery disease (CAD) patients undergoing percutaneous coronary intervention (PCI) are vulnerable to various cardiovascular complications, including cardiac death, myocardial infarction (MI), in-stent restenosis, and decreased exercise tolerance [1][2][3]. Furthermore, many studies have shown that atherosclerosis is an inflammatory process.…”

Section: Introductionmentioning

confidence: 99%

Effects of cardiac rehabilitation on inflammatory biomarkers in unstable ischemic heart disease patients following percutaneous coronary intervention: a randomized controlled study

Awada,

Sanaei,

Jameie

et al. 2023

Coronary Artery Disease

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Introduction Several blood inflammatory markers, such as high-sensitivity C-reactive protein (hs-CRP), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), are linked to increased risk for cardiovascular diseases. This study aimed to evaluate these inflammatory markers after cardiac rehabilitation (CR) in patients with unstable ischemic heart disease (UIHD) who underwent successful percutaneous coronary intervention (PCI). Methods A cohort of 115 patients with successful PCI due to UIHD enrolled in the study from January 2018 to March 2021. We used a permuted block stratified randomization technique (2 : 1 ratio). Seventy-seven patients were randomized to the CR group and 38 patients to the control group. The CR group underwent a 12-week pre-specified CR regimen. Blood samples were taken at baseline and follow-up at 12 weeks for both groups. Result Among the 115 patients, 33 patients were female. The mean age was (53 ± 5.55 years) in the control and (53 ± 6.09 years) in the CR group. The two groups were comparable regarding their baseline characteristics and the values of the inflammatory markers. By contrast, at 12 weeks, the inflammatory marker values were significantly lower in the CR group compared to the control group; hs-CRP: 0.11 [0.08–0.14] vs. 0.21 [0.19–0.21], P-value <0.001; NLR: 2.17 [1.42–2.43] vs. 2.26 [2.07–2.6], P-value: 0.016; PLR: 91.2821 [63.3333–103.2000] vs. 92.600 [84.6154–110.0000], P-value: 0.027. Conclusion CR after PCI in UIHD patients may attenuate some inflammatory markers, which might benefit cardiovascular health. Further studies are required to evaluate these findings with longer follow-up and the powered to measure major cardiovascular event rates.

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Section: Introductionmentioning

confidence: 99%

Effects of cardiac rehabilitation on inflammatory biomarkers in unstable ischemic heart disease patients following percutaneous coronary intervention: a randomized controlled study

Awada,

Sanaei,

Jameie

et al. 2023

Coronary Artery Disease

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“…Процентное соотношение обнаруженных и необнаруженных каузативных вариантов у пробандов в собственном проводимом исследовании сопоставимо с мировыми данными. К примеру, в работе по полноэкзомному секвенированию 60 человек, выживших после внезапной остановки сердца, только в 45% случаев найдены варианты, объясняющие это событие [29].…”

Section: Discussionunclassified

Sudden cardiac death in young athletes: exome sequencing results

Deev,

Kadykova,

Shilova

et al. 2024

Genes & Cells

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Ranking risks and prevention of sudden cardiac death in professional young athletes is one of the important unresolved problems in sports medicine. Intense physical exertion can lead to adaptive changes in the cardiovascular system, which can mask some inherited diseases with predominant myocardial involvement, such as hypertrophic cardiomyopathy. Undiagnosed cases of such diseases can be a risk factor for fatal outcomes associated with training and competitive activities, making this problem extremely relevant. The aim was to conduct a diagnostic search for possible molecular causes of cardiovascular diseases associated with a high risk of sudden death in young athletes. Methods. Whole-exome sequencing of DNA extracted from two groups of biomaterials was performed: 9 autopsy samples of heart tissues from young athletes who died during intense physical exertion, and 3 samples of venous blood from active athletes of the Russian national teams. The obtained data were subjected to bioinformatic analysis and clinical interpretation. Results. A total of 12 DNA samples were analyzed using a panel of 277 genes associated with the development of cardiovascular diseases with a high risk of sudden death. In 4 out of 12 samples (33.3%), variants likely related to the phenotype were found upon clinical interpretation of the sequencing results. A pathogenic variant was found in the MYBPC3 gene, leading to the development of hypertrophic cardiomyopathy (OMIM: 115197), and a likely pathogenic variant was found in the TRPM4 gene, associated with progressive familial heart block type IB (OMIM: 618531). Two variants with uncertain clinical significance were also found in the CAV3 and SCN1B genes. Conclusion. Currently, data from high-throughput sequencing are being accumulated to search for the molecular basis of cardiovascular diseases with a high risk of sudden cardiac death. Identifying young athletes who are carriers of pathogenic and likely pathogenic gene variants is an effective measure for preventing fatal outcomes and personalizing medical support for professional athletes.

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“…Foi identificado, neste estudo, que níveis elevados de CT estiveram relacionados a maior RCV. Análise de uma coorte iraniana com 6.504 indivíduos revelou que a presença de dislipidemia pode aumentar o risco de DCVs e suas complicações, em 15 anos, em 1,59 vezes mesmo após ajuste para fatores de confundimento 36 .…”

Section: Discussionunclassified

Risco cardiovascular em hipertensos e diabéticos acompanhados em uma unidade básica de saúde

Cunha,

França,

Santos

et al. 2023

SaudPesq

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Determinar o risco cardiovascular pelo Escore de Framingham em indivíduos hipertensos e/ou diabéticos acompanhados em uma unidade de saúde. Estudo transversal com 141 indivíduos com avaliação de dados sociodemográficos, econômicos, clínicos, nutricionais e laboratoriais e aplicação do Escore de Framingham. A média de idade foi 58,5 ±10,5 anos; 67,4% foram mulheres; prevalência de hipertensão arterial, 79,4%, diabetes mellitus, 46,8%; e ambas as comorbidades, 26,2%. A análise apontou diferença por sexo: mulheres apresentaram maior índice de massa corporal (p=0,002), colesterol total (p=0,047) e lipoproteína de alta densidade (p

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15-Year lipid profile effects on cardiovascular events adjusted for cardiovascular risk factors: a cohort study from Middle-East

Cited by 10 publications

References 24 publications

Effects of cardiac rehabilitation on inflammatory biomarkers in unstable ischemic heart disease patients following percutaneous coronary intervention: a randomized controlled study

Effects of cardiac rehabilitation on inflammatory biomarkers in unstable ischemic heart disease patients following percutaneous coronary intervention: a randomized controlled study

Sudden cardiac death in young athletes: exome sequencing results

Risco cardiovascular em hipertensos e diabéticos acompanhados em uma unidade básica de saúde

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