16. Endolumenal Approaches to Gastroesophageal Reflux Disease

Reavis, Kevin M.; Nguyen, Allan

doi:10.1007/978-1-4614-2347-8_16

Cited by 2 publications

(1 citation statement)

References 26 publications

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“…26,27 The mechanisms of action of these procedures included decrease of proximal migration of acid reflux, decrease of transient lower esophageal sphincter relaxation (TLESR) rate, mechanical obstruction of reflux, increase in lower esophageal sphincter (LES) basal pressure, and possibly decrease of esophageal sensitivity to reflux. Currently there are 2 endolumenal procedures that are clinically available and another one that is under investigation.…”

Section: Endoscopic Therapymentioning

confidence: 99%

Nonmedical Therapeutic Strategies for Nonerosive Reflux Disease

Maradey–Romero

Kale

Fass

2014

Journal of Clinical Gastroenterology

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There has been a marked decline over the last several years in drug development for gastroesophageal reflux disease and specifically for nonerosive reflux disease (NERD), despite there being many areas of unmet need. In contrast, we have seen a proliferation, during the same period of time, in development of novel, nonmedical therapeutic strategies for NERD using cutting-edge technology. Presently, compliance and lifestyle modifications are readily available noninvasive therapeutic interventions for NERD. Other nonmedical therapies include, the Stretta procedure, transoral incisionless fundoplication, and the magnetic sphincter augmentation device (LINX). Antireflux surgery, in experienced hands, has been repeatedly shown to be efficacious in resolving NERD-related symptoms. Psychological therapeutic interventions and alternative medicine techniques, such as acupuncture, continue to show promise, especially in NERD patients who failed antireflux treatment.

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Section: Endoscopic Therapymentioning

confidence: 99%