1998
DOI: 10.1089/jir.1998.18.921
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16-Epiestriol, a Novel Anti-Inflammatory Nonglycogenic Steroid, Does Not Inhibit IFN-γ Production by Murine Splenocytes

Abstract: All the steroidal anti-inflammatory drugs currently available are glucocorticoids. The desired anti-inflammatory activities of glucocorticoids frequently are accompanied by adverse side effects, notably glycogenic activities and profound immunosuppression, that can limit clinical use. We recently identified 16-epiestriol, a naturally occurring steroid, as exhibiting significant anti-inflammatory activity without glycogenic activity. In the present study, we compared the effects of 16-epiestriol and hydrocortis… Show more

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“…16-epi-estriol has been demonstrated to possess strong anti-inflammatory effects without profound immunosuppressive or glycogenic activities. 31, 32 17-epi-estriol possesses negative effects on inflammatory and adhesion by suppressing TNFα-induced and nitric oxide-mediated VCAM-1 expression. 33 Thus, since preeclampsia is associated with abnormal increased expression of adhesion molecules and increased levels of pro-inflammatory cytokines that induce alterations in vascular vasodilatory responsiveness, 34 our findings suggest the first possibility that low 16-epi-estriol and 17-epi-estriol may potentially contribute to perturbations in inflammatory and impaired adhesion responses in preeclampsia.…”
Section: Discussionmentioning
confidence: 99%
“…16-epi-estriol has been demonstrated to possess strong anti-inflammatory effects without profound immunosuppressive or glycogenic activities. 31, 32 17-epi-estriol possesses negative effects on inflammatory and adhesion by suppressing TNFα-induced and nitric oxide-mediated VCAM-1 expression. 33 Thus, since preeclampsia is associated with abnormal increased expression of adhesion molecules and increased levels of pro-inflammatory cytokines that induce alterations in vascular vasodilatory responsiveness, 34 our findings suggest the first possibility that low 16-epi-estriol and 17-epi-estriol may potentially contribute to perturbations in inflammatory and impaired adhesion responses in preeclampsia.…”
Section: Discussionmentioning
confidence: 99%