16 Low Molecular Weight Peptides

Reichelt, Karl L.

doi:10.1007/978-0-387-30373-4_16

Cited by 2 publications

(3 citation statements)

References 76 publications

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“…This finding fits similar data from depression reported elsewhere [8]. That most of these peptides present were found in the same peak of material eluting together and later than the standards, demonstrates the problem in peptide work caused by peptide aggregation [12,13]. Peptides like amino acids are really Zwitterions as demonstrated in Figure 5.…”

Section: Discussionsupporting

confidence: 80%

“…The peaks of material retarded and eluting later than 48 ml dominate as usually seen in Depression [8] in this schizoaffective patient without medication. by peptides is extensive [12,13]. In addition adducts with Sodium.…”

Section: Resultsmentioning

confidence: 99%

“…The declustering potential was set to 20 so as to reduce splitting, which we saw at higher potentials. Even so we retained a dimer underlining the problem of adjuncts and aggregation in all peptide work [12].…”

Section: Resultsmentioning

confidence: 99%

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Exorphins in urine from schizoaffective psychotics

Tveiten¹,

Reichelt²

2012

OJPsych

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Hyperpeptiduria and opioid excess have been reported in schizophrenia. According to Prof. Dr. L. Lindström, Sweden opioids may explain the pathophysiology of this syndrome. Therefore it is critical to elucidate the presence and nature of opioids in schizophrenia and diagnostic sub groups. First morning urine from untreated schizoaffective patients (ICD-10: F 25.1) was separated on HPLC and peaks that elute where different opioid standards appear, freeze dried, re-dissolved in methanol/water (50/50) and 10 mM formic acid. Mass spectrometry and MS/MS or fragmentation mass spectrometry was performed. We found fragmentation pattern of beta-casomorphin 1 -3 and 1 -4 (bovine) identical to synthetic standards from Bachem. The aggregation tendency of peptides was much in evidence. The reported exorphins were found in the urine from 8 of 12 untreated schizoaffective patients.

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Section: Discussionsupporting

confidence: 80%

Section: Resultsmentioning

confidence: 99%

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Exorphins in urine from schizoaffective psychotics

Tveiten¹,

Reichelt²

2012

OJPsych

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Genetic and dietary factors related to schizophrenia

Reichelt¹,

Gardner²

2012

OJPsych

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Biochemical, immunological and epidemiological evidence increasingly support the suggestion that there is a causal relationship between gluten/gliadin and schizophrenia as originally proposed by F. C. Dohan. Furthermore the necessary physiological mechanisms exist to explain a mechanism involving bioactive peptides from these proteins, and these show that this mechanism is possible and probable in at least in a substantial subgroup of schizophrenic patients. Evidence shows a fairly strong genetic disposition, and it must be recognised that any genetic mechanism must implicate altered chemistry and function of proteins. Evidence supports the likelihood that dietary intervention is beneficial for some, and this demands further investigation. A similar conclusion may apply to autism spectrum conditions

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16 Low Molecular Weight Peptides

Cited by 2 publications

References 76 publications

Exorphins in urine from schizoaffective psychotics

Exorphins in urine from schizoaffective psychotics

Genetic and dietary factors related to schizophrenia

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