This chapter describes the differences in HIV care and management for persons with HIV who are 50 years old or older compared to their younger counterparts. Importantly, older patients with HIV present unique and complex cases and disease-centric guidelines do not apply to every patient. Management of diseases in older patients with HIV should be individualized based on aging phenotypes identified by the Veterans Aging Cohort Study (VACS) index, interactions with multiple morbidities, and patient preferences. Learners will understand how to conduct a comprehensive geriatric assessment to assess for function, mobility/fall risk, frailty, cognition, mood, and issues related to polypharmacy. Learners will also discuss a comprehensive medication assessment, nutrition and weight changes, social and monetary issues impacting care, symptom burdens and pain, and advance planning. Lastly, learners will be presented with specific coexisting conditions common to aging that are impacted by HIV, including diabetes mellitus, hypertension, bone disease, peripheral neuropathy, certain cancers, and recommended vaccinations.