1670: Neutropenic Septic Shock Outcomes in Cancer Patients and the Influence of Colony-Stimulating Factor

Laserna, Andrés; Fowler, Cosmo; O’Connell, Keara; Manjappachar, Nirmala; Martin, Peyton; Cuenca, John; Urso, Catherine; Gutiérrez, Cristina; Malik, Imrana; Erfe, Rose; Cardenas, Yenny; Price, Kristen; Nates, Joseph

doi:10.1097/01.ccm.0000648584.83810.1e

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Reilly et al reported that neutropenic sepsis was independently associated with a higher risk of acute kidney injury, but not with 30-day mortality [ 31 ]. Furthermore, a previous study investigating 464 septic shock patients admitted to the oncologic ICU showed no difference in mortality between the neutropenic and non-neutropenic groups [ 32 ]. This study showed that neutropenia was independently associated with decreased mortality after adjusting for potential confounders.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Impact of Neutropenia in Cancer Patients with Septic Shock: A 2009–2017 Nationwide Cohort Study

Kim

2022

Cancers

View full text Add to dashboard Cite

(1) Background: Neutropenia’s prognostic impact on mortality in cancer patients with septic shock remains controversial despite recent advances in cancer and sepsis management. This population-based, case–control study aimed to determine whether neutropenia could be related to an increase in short-term and long-term mortality. (2) Methods: This population-based, case–control study used data from the National Health Insurance Service of Korea. Adult cancer patients who presented to the emergency department with septic shock from 2009 to 2017 were included. The 30-day and 1-year mortality rates were evaluated as short-term and long-term outcomes. Cox proportional hazard regression was performed after adjusting for age, sex, Charlson comorbidity index, and neutropenia. (3) Results: In 43,466 adult cancer patients with septic shock, the 30-day and 1-year mortality rates were 52.1% and 81.3%, respectively. In total, 6391 patients had neutropenic septic shock, and the prevalent cancer type was lung cancer, followed by leukemia, non-Hodgkin’s lymphoma, stomach cancer, and colon cancer. Furthermore, 30-day and 1-year mortality was lower in patients with neutropenia than in those without neutropenia. After adjustment for confounders, neutropenia was independently associated with decreased 30-day and 1-year mortality rates. (4) Conclusions: In cancer patients presenting to the emergency department with septic shock, the presence of neutropenia did not increase mortality. This suggests that neutropenia may not be used as a single triage criterion for withholding intensive care in cancer patients presenting to the emergency department with septic shock.

show abstract

Section: Discussionmentioning

confidence: 99%

Prognostic Impact of Neutropenia in Cancer Patients with Septic Shock: A 2009–2017 Nationwide Cohort Study

Kim

2022

Cancers

View full text Add to dashboard Cite

show abstract

1670: Neutropenic Septic Shock Outcomes in Cancer Patients and the Influence of Colony-Stimulating Factor

Cited by 1 publication

References 0 publications

Prognostic Impact of Neutropenia in Cancer Patients with Septic Shock: A 2009–2017 Nationwide Cohort Study

Prognostic Impact of Neutropenia in Cancer Patients with Septic Shock: A 2009–2017 Nationwide Cohort Study

Contact Info

Product

Resources

About