1682P Effects of a walking football program on muscle strength and balance of androgen deprived prostate cancer patients: The Prostata_Move trial

Abstract

Methods: BCS older than 18 yo who had finished their treatment and were able to walk a mile. BMI, waist, and hip perimeter were used to assess body composition. Cardio-respiratory fitness was assessed using the one-mile walk test. Then, VO2peak was estimated according to Kline equation. Handgrip strength (superior muscular strength) was measured using a dynamometer. The sit to stand test (inferior muscular strength) measures the seconds required to perform five consecutive repetitions of sitting down and uprising. Biomarkers potentially related to PA were analysed, namely estrogens, progesterone, testosterone, androsterone, insulin, IGF-I, IGBBP-3, NLR, CRP, cortisol.Results: 84 BCS were recruited. Testosterone levels were associated with recovery heart rate. Insulin levels were inversely associated with estimated VO2peak, gait speed and basal heart rate. CRP was inversely associated with VO2peak, gait speed, inferior muscular strength. CRP was positively associated with BMI and hip perimeter.Conclusions: CRP (but not NLR) was associated with all the domains of physical condition, namely cardiorespiratory fitness, muscular strength, and adiposity. Insulin (but not IGF-I, IGBBP-3) was associated with the cardiorespiratory component. Some biomarkers such as CRP and insulin could be modified by physical condition more than by physical activity. Plasmatic CRP levels have been associated with risk of CV disease. Improving the physical condition of BCS could be useful to improve the CV risk in BCS, which continues to be the most important cause of death in this population.