16α-Hydroxysteroids. XIII.^* Carbonyl Reduction by Streptomyces roseochromogenus

Abstract

Streptomyces roseochromogenus fermentations of 9 -fluorohy drocortisone result in a small amount of C2o-carbonyl reduction, the 20/3-dihydro derivatives of both 9«-fluorohydrocortisone and 16 -hy droxy-9 -fl uorohy drocortisone being formed. Fermentations of 9 a-fluorohydrocortisone-21-aldehyde result in rapid and complete reduction of the aldehyde to 9a-fluorohydrocortisone, which is then altered characteristically by the microorganism.

Bioconversion of steroids by Cochliobolus lunatus. I. Transformation of Reichstein's compound S with cell‐free preparations of Cochliobolus lunatus

“…The combination of steroid hydroxylations with steroid reductase reactions is well known, but so far the simultaneous 20j3-reduction and the hydroxylation of steroid compounds has only been reported in a few communications (SMITH et al 1962, KOGAN et al 1965, ELIN et al 1969, DE ROSA et al 1981.…”