17. Neuroleptic effects on regional brain metabolism in first episode schizophrenics

Cleghorn, John M.; Szechtman, Henry; Garnett, E. S.; Brown, Gregory M.; Nahmias, Claude; Szechtman, Barbara; Kaplan, Ronald D.; Franco, S.

doi:10.1016/0920-9964(91)90077-5

Cited by 13 publications

(10 citation statements)

References 7 publications

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“…In patients with schizophrenia, most (Szechtman et al 1988;Wik et al 1989;Bartlett et al 1991;Buchsbaum et al 1992b;Holcomb et al 1996;Wolkin et al 1996), but not all (Volkow et al 1986;Resnick et al 1988;Cleghorn et al 1991;Buchsbaum et al 1992a), studies also show changes in thalamic activity in response to antipsychotic drugs, as measured by glucose uptake and positron emission tomography (PET). However, in these studies, patients received various drugs and were studied after various lengths of time, from 1 day to 7 years, of treatment, so that the consistent and shared e¤ects of drugs are di¦cult to determine.…”

Section: Introductionmentioning

confidence: 92%

“…Complementing structural studies, most but not all (Kling et al 1986;Volkow et al 1986;Early et al 1987;Cleghorn et al 1991;Gur et al 1995) functional studies of the thalamus report abnormalities in schizophrenia. This includes studies of resting regional cerebral blood ßow (Vita et al 1995;Lewis et al 1992) and regional cerebral metabolism (Wiesel et al 1987;Tamminga et al 1992;Buchsbaum et al 1996).…”

Section: Introductionmentioning

confidence: 93%

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Activation of midline thalamic nuclei by antipsychotic drugs

et al. 1998

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The thalamus has been proposed as a site which may be involved in the production of the syndrome of schizophrenia and the response of schizophrenic symptoms to treatment. These studies test whether, consistent with this hypothesis, the activation of thalamic nuclei is a shared property of neuroleptic antipsychotic drugs. Rats were given single doses of the typical high and low potency neuroleptics haloperidol (1 mg/kg) and chlorpromazine (20 mg/kg), the atypical neuroleptics thiroridazine (20 mg/kg) and clozapine (20 mg/kg), the specific dopamine antagonist raclopride (3 mg/kg), the mixed dopamine/serotonin antagonist risperidone (3 mg/kg) or drug-free vehicle. Increased expression of Fos-like protein was utilized as a marker of cellular activation. All drugs tested, including typical and atypical antipsychotic agents, led to similar effects on the midline thalamic paraventricular, centromedian and rhomboid nuclei and the nucleus reuniens. These results suggest that midline thalamic nuclei may participate in neural circuits mediating some of the shared effects of antipsychotic drugs.

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Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 93%

Activation of midline thalamic nuclei by antipsychotic drugs

et al. 1998

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“…Neuroleptic-related increases in with their diminished potential for motor sidestriatal metabolism were also found in most other effects (Figs 3 and 4). studies (21)(22)(23)(24)(25)(26)(27)(28)(29)(30), but not in all of them (31).…”

Section: Figmentioning

confidence: 99%

Visualizing fronto‐striatal circuitry and neuroleptic effects in schizophrenia

Buchsbaum

Hazlett

Haznedar

et al. 1999

Acta Psychiatr Scand

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Disturbances in fronto‐striatal circuitry have been postulated to be important in schizophrenia. Positron emission tomography typically shows decreased metabolic rates in these areas relative to other brain areas in schizophrenia. After treatment with typical neuroleptics, striatal metabolic rates are increased, but other brain areas tend not to show significant changes. Atypical neuroleptics less markedly affect striatal metabolic rates, but show wider cortical effects. In order to examine fronto‐striatal circuitry, a technique for visualizing the correlations between metabolic rates in all brain areas was applied in 33 controls and 27 unmedicated schizophrenic patients. Correlation images revealed strong fronto‐striatal connections in controls, but weak fronto‐striatal links in schizophrenic patients. Changes in striatal circuits, also reflected in recent anatomical studies, may be important for understanding antipsychotic effects.

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“…Although the use of PET to measure the effects of pharmacological agents on rCBF in schizophrenic patients has not been reported, Cleghorn et al (1991) have demonstrated that the dopamine agonist apomorphine produces a decrease in glucose metabolism in the caudate nucleus in schizophrenic patients, but not in normal subjects.…”

Section: Pharmacological Activationmentioning

confidence: 99%

PET scanning and schizophrenia – what progress?

Liddle¹

1992

Psychol. Med.

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17. Neuroleptic effects on regional brain metabolism in first episode schizophrenics

Cited by 13 publications

References 7 publications

Activation of midline thalamic nuclei by antipsychotic drugs

Activation of midline thalamic nuclei by antipsychotic drugs

Visualizing fronto‐striatal circuitry and neuroleptic effects in schizophrenia

PET scanning and schizophrenia – what progress?

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