1756P Cancer patients infected with COVID-19 at La Princesa Hospital: Real-world data study

Abstract

Background: The COVID-19 pandemic has meant a change in health care worldwide, and cancer patients are a particularly vulnerable population with their own clinical and therapeutic characteristics. Due to the lack of new evidence on what the best approach should be in the context of the current pandemic, it is essential to go further in the knowledge of the characteristics of this infection in cancer patients and its outcomes.Methods: From March 1 to April 30, 2020, we collected and analysed data of 1202 cancer patients who were under active treatment or follow-up at the Medical Oncology Department of La Princesa Hospital and had a COVID-19 PCR test due to clinical symptoms (216 patients tested).Results: We detected a total of 50 patients with positive PCR (a 4,1% of the total number of patients in the period analysed). The mean age at diagnosis of the infection was 69, 52% were women and 16% smokers. The most frequent diagnoses were breast cancer (28%), colon cancer (26%), and lung cancer (14%) (Figure 1). 60% were localized stages, 36% were undergoing chemotherapy and 8% with immunotherapy. Fourteen of the 50 infected patients died (28%), Thirty-seven patients (74%) required hospitalization, with a mean age of 73. Twenty patients received high-dose corticosteroids and four Tocilizumab. One patient was admitted to the ICU. Hospital mortality was 35.1%, being 57% male and with a mean age of 80. Three patients presented grade 3 neutropenia at diagnosis, none of whom died. Two hospitalized patients were diagnosed of acute pulmonary thromboembolism regarding to coronavirus infection. Conclusions:The aggressiveness of COVID-19 infection in cancer patients is high. In our center we had an incidence of 4.1%, an admission rate of 74%, an overall mortality rate of 28%, and a hospital mortality rate of 35%. These figures are higher than those described in non-oncological population. Neutropenia did not seem to be a poor prognostic factor among infected patients in our series.Legal entity responsible for the study: The authors.

Emotional Distress in Cancer Patients During the First Wave of the COVID-19 Pandemic

“…The greater physical vulnerability of cancer patients infected with Sars-Cov-2 seems to be related to the state of immunosuppression associated, caused by the tumor process itself and by the administration of antineoplastic treatments, the presence of comorbidities, and the need to regularly visit a hospital (Miyashita et al, 2020;Petrova et al, 2020;Zhang et al, 2020). At Hospital Universitario de La Princesa we recently published a mortality rate for COVID-19 disease in cancer patients of 33% (Toquero Diez et al, 2020), similar to that reported in other national and international centers (Lee et al, 2020).…”

Data_Sheet_1.docx

“…The greater physical vulnerability of cancer patients infected with Sars-Cov-2 seems to be related to the state of immunosuppression associated, caused by the tumor process itself and by the administration of antineoplastic treatments, the presence of comorbidities, and the need to regularly visit a hospital (Miyashita et al, 2020;Petrova et al, 2020;Zhang et al, 2020). At Hospital Universitario de La Princesa we recently published a mortality rate for COVID-19 disease in cancer patients of 33% (Toquero Diez et al, 2020), similar to that reported in other national and international centers (Lee et al, 2020).…”