1774P The study of physical and mental distress among cancer patients during the COVID-19 epidemic

Abstract

Background: Small case series of patients with active cancer and coronavirus infection have been described since the beginning of the pandemic. The patients most affected by this infection are those with lung cancer but it also affects other types of cancer such as breast cancer. We described the characteristics of patients with breast cancer and COVID 19, their associated risk factors, treatment and evolution.Methods: We reviewed 2216 medical records of all patients admitted to hospitalization with COVID-19 diagnosis between 5 March and 13 May 2020. Study data were collected and managed using RedCap electronic data capture tools. We described breast cancer patients, associated risk factors, mortality and outcome.Results: We detected 85/2216patients cancer with a mortality rate 47% (40/85). Of all cancer patients, 11% (10/85) had breast cancer. Median age breast cancer patients was 70.5 years old (35-86). Most frecuent staging was locally advanced (50 %, 5/10) and most of them were on hormone therapy (50%, 5/10). As associated risk factors, 20% (2/10) had heart disease, 50% (5/10) had hypertension, 20 (2/10) were obese, 30% (3/10) had diabetes, 40% (4/10) had dyslipemia and only 10% (1/10) was smoker. Half the patients 50% (5/10) had bilateral pneumonia, none of them were admitted to the ICU and 20% (2/10) died. All patients were treated with the combination of azithromycin and hydroxychloroquine and 40% (4/10) with lopinavir/ritonavir. Mortality was associate with high LDH levels (1529 vs. 264 U/L, p¼0,0002), high PCR levels (159.15 vs. 29 mg/L, p¼0.0140), ARDS (1/1 vs. 1/9 without ARDS p¼0.035). A posible relation has been found with history of hypertension (2/5 vs. 0/5 without hypertension, p¼0.114) and bilateral pneumonia (2/5 vs. 0/5, p¼ 0.114).Conclusions: COVID 19 appears to have lower mortality in breast cancer patients than in other tumor types. High LDH and PCR levels and ARDS could be related with increased risk of death. Combined treatment in these patients with azithromycin and hydroxychloroquine might be a good option.Legal entity responsible for the study: The authors.

A living systematic review of the psychological problems in people suffering from COVID-19

“…The cumulative number of people infected with SARS-CoV-2 has exceeded 100 million across the globe( WHO, 2021 ). Many studies have confirmed that the global pandemic has caused a wide range of psychosocial problems( Brooks et al, 2020 ; Galea et al, 2020 ; Kisely et al, 2020 ; Naqos and Khouchani, 2020 ). As for people infected by SARS-CoV-2, who have attracted the most concern, great attention must be paid to their psychological problems, regardless of asymptomatic patients, patients with mild symptoms, or clinically cured patients( Bo et al, 2020 ; Mazza et al, 2020 ; Wu et al, 2020 ).…”

Immediate Psychosocial Impact on Healthcare Workers During COVID-19 Pandemic in China: A Systematic Review and Meta-Analysis

“…Due to the unpredictability of the disease and the necessary isolation of patients, those who have been diagnosed with COVID-19 and people who have been medically quarantined were very likely to be anxious and depressed (Bo et al, 2020;Wang C. et al, 2020). According to existing research, patients with cancer and other underlying diseases exhibited increased psychological discomfort during the COVID-19 pandemic and received different levels of mental health services (Naqos and Khouchani, 2020;. Therefore, the COVID-19 pandemic has also posed high risks for other patients.…”