179 Pulmonary deposition of inhaled tobramycin (TOBI), before and after physiotherapy and inhaled salbutamol in Cystic Fibrosis (CF) patients

Original research articles on the cardiopulmonary system recently appeared in Brazilian clinical and surgical journals

“…CyStiC fiBroSiS Pulmonary function. Four articles cover this topic [116][117][118][119] . Respiratory therapy followed by the use of inhaled albuterol was evaluated to determine whether it modifies the pulmonary deposition of inhaled tobramycin in patients with cystic fibrosis and whether pulmonary deposition correlates with disease severity or genotype; it was concluded that the use of a respiratory therapy technique and the administration of inhaled albuterol immediately prior to the use of inhaled tobramycin decreased the pulmonary deposition of the latter in CF patients, and this reduction correlates with disease severity and genotype 116 .…”

“…Four articles cover this topic [116][117][118][119] . Respiratory therapy followed by the use of inhaled albuterol was evaluated to determine whether it modifies the pulmonary deposition of inhaled tobramycin in patients with cystic fibrosis and whether pulmonary deposition correlates with disease severity or genotype; it was concluded that the use of a respiratory therapy technique and the administration of inhaled albuterol immediately prior to the use of inhaled tobramycin decreased the pulmonary deposition of the latter in CF patients, and this reduction correlates with disease severity and genotype 116 . The association between nutritional status measurements and pulmonary function in children and adolescents with cystic fibrosis was analyzed and the conclusion was that all nutritional status measurements correlated directly with the pulmonary function of children and adolescents with cystic fibrosis.…”

Early Evaluation of the Efficiency of Antibiotic Therapy for Nosocomial Pneumonia by Quantifying Lipopolysaccharide

“…Methods of early bacterial identification in concert with the estimation of antibiotic sensitivity might have limited avail ability due to technological problems and high cost of analyz ing equipment and operating materials. The significance of Earlier studies showed an increase in LPS binding pro tein and endotoxin concentrations in patients with severe pneumonia, however, the dynamics of these molecules during the antibacterial therapy was not evaluated [28,29]. Analysis of the arterial venous difference of gram negative bacteria LPS level might provide information on detoxifying activities of the lungs detoxicant activity as well as on the site of the gram negative infection in the pulmonary circuit.…”