17DD yellow fever vaccine

Felzemburgh, Ridalva Dias Martins; Maia, Maria de Lourdes Sousa; Farias, Roberto Henrique Guedes; Camacho, Luiz Antônio Bastos; Freire, Marcos S.; Galler, Ricardo; Yamamura, Anna Maya Yoshida; Almeida, Luiz F.C.; Lima, Sheila Maria Barbosa de; Nogueira, Rita Maria Ribeiro; Sá, Glória Regina Silva e; Hokama, Darcy Akemi; Carvalho, Ricardo de Souza; Freire, Ricardo Aguiar Villanova; Filho, Edson Pereira; Leal, M; Homma, Akira

doi:10.4161/hv.22982

Cited by 106 publications

(69 citation statements)

References 29 publications

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“…The fourth scenario is based on an experimental study [32] in which distinct doses of the YF vaccine were tested. Compared to the standard dose, the experimental study reported that, to some extent, the reduction did not significantly affect the percentage of sero-conversion.…”

Section: Resultsmentioning

confidence: 99%

“…In this scenario, computational experiments are executed several times, using distinct values for the vaccine doses. For comparison purposes, the computational experiments were carried out using the same values of the experimental study [32]. …”

Section: Resultsmentioning

confidence: 99%

“…1 by V (all initial conditions are presented in Table 2). In fact, in the case of the 17DD-YFV the amount of virus particles varies depending on the vaccine lot number, ranging from 2.3 to 12 times the minimum value required by the WHO [32]. The 17DD-YFV is the YF vaccine developed by Bio-Manguinhos/Fiocruz, one of the three producers prequalified by the WHO to supply vaccines to international agencies.…”

Section: Resultsmentioning

confidence: 99%

“…Figure 3 shows the viremia curve obtained by the simulation of the model in comparison with the experimental data obtained from the literature [32].

Fig.…”

Section: Resultsmentioning

confidence: 99%

“…What is the vaccine dose with the best immunogenicity/reatogenicity ratio? There are clinical studies designed to evaluate this [32], but these studies require time and resources, and there are methodological restrains to test several different doses. With the use of mathematical and computational modeling techniques, it is possible to evaluate a larger spectrum of doses in a much shorter time, using far less resources.…”

Section: Introductionmentioning

confidence: 99%

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A qualitatively validated mathematical-computational model of the immune response to the yellow fever vaccine

et al. 2018

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BackgroundAlthough a safe and effective yellow fever vaccine was developed more than 80 years ago, several issues regarding its use remain unclear. For example, what is the minimum dose that can provide immunity against the disease? A useful tool that can help researchers answer this and other related questions is a computational simulator that implements a mathematical model describing the human immune response to vaccination against yellow fever.MethodsThis work uses a system of ten ordinary differential equations to represent a few important populations in the response process generated by the body after vaccination. The main populations include viruses, APCs, CD8+ T cells, short-lived and long-lived plasma cells, B cells and antibodies.ResultsIn order to qualitatively validate our model, four experiments were carried out, and their computational results were compared to experimental data obtained from the literature. The four experiments were: a) simulation of a scenario in which an individual was vaccinated against yellow fever for the first time; b) simulation of a booster dose ten years after the first dose; c) simulation of the immune response to the yellow fever vaccine in individuals with different levels of naïve CD8+ T cells; and d) simulation of the immune response to distinct doses of the yellow fever vaccine.ConclusionsThis work shows that the simulator was able to qualitatively reproduce some of the experimental results reported in the literature, such as the amount of antibodies and viremia throughout time, as well as to reproduce other behaviors of the immune response reported in the literature, such as those that occur after a booster dose of the vaccine.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Figure 3 shows the viremia curve obtained by the simulation of the model in comparison with the experimental data obtained from the literature [32].

Fig.…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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