17α-Ethinylestradiol (EE2) treatment of wild roach (Rutilus rutilus) during early life development disrupts expression of genes directly involved in the feedback cycle of estrogen

Nikoleris, Lina; Hultin, Cecilia; Hallgren, Per; Hansson, Maria

doi:10.1016/j.cbpc.2015.12.002

Cited by 16 publications

(14 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are no available epidemiological reports of EE2 and its effects on human sensory systems. However, EE2 binds to teleost and mammalian ERs ( Aten and Eisenfeld, 1982 ), and environmentally relevant levels adversely affect fish ( Nikoleris et al, 2016 ; Tang et al, 2021 ; Ramirez-Montero et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

The Role of Estrogen and Thyroid Hormones in Zebrafish Visual System Function

et al. 2022

View full text Add to dashboard Cite

Visual system development is a highly complex process involving coordination of environmental cues, cell pathways, and integration of functional circuits. Consequently, a change to any step, due to a mutation or chemical exposure, can lead to deleterious consequences. One class of chemicals known to have both overt and subtle effects on the visual system is endocrine disrupting compounds (EDCs). EDCs are environmental contaminants which alter hormonal signaling by either preventing compound synthesis or binding to postsynaptic receptors. Interestingly, recent work has identified neuronal and sensory systems, particularly vision, as targets for EDCs. In particular, estrogenic and thyroidogenic signaling have been identified as critical modulators of proper visual system development and function. Here, we summarize and review this work, from our lab and others, focusing on behavioral, physiological, and molecular data collected in zebrafish. We also discuss different exposure regimes used, including long-lasting effects of developmental exposure. Overall, zebrafish are a model of choice to examine the impact of EDCs and other compounds targeting estrogen and thyroid signaling and the consequences of exposure in visual system development and function.

show abstract

Section: Introductionmentioning

confidence: 99%

The Role of Estrogen and Thyroid Hormones in Zebrafish Visual System Function

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Due to its estrogenic effects and development toxicity, many studies have focused on the impairment caused by EE2 in embryos (Santos et al, 2014; Ortiz‐Zarragoitia et al, 2006) and fry (Nikoleris et al, 2016) or on the impairment of the reproductive system, behaviour and sexual morphology of adult fish (Young et al, 2017; Hua et al, 2016; Sridevi et al, 2015; Kidd et al, 2007; Santos et al, 2007; Forette et al, 2015; Baatrup & Henriksen, 2015; Volkova et al, 2015). However, whether EE2 is capable of disrupting balanced osmoregulation of fish remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Short‐term exposure of 17α‐ethynylestradiol impairs water homeostasis by inhibiting osmoregulatory and cortisol regulating genes in adult zebrafish

Xie

et al. 2022

Aquaculture Research

View full text Add to dashboard Cite

The aim was to study the effect of 17α‐ethynylestradiol (EE2) on osmoregulation of fish, adult zebrafish (Danio rerio) were exposed to 10 ng/L and 100 ng/L of EE2 for 7 days. After exposure, EE2 induced body oedema, trichangiectasis in the skin and protrusion of the proptosis and significantly elevated the condition factor, water weight and water content, decreased the RBC count and HCT of the fish. In addition, various histopathological damages in the gill and kidney were observed. We therefore speculate that EE2 exposure may disrupt water homeostasis in zebrafish. Further research found that the mRNA levels of crh, crhr and acth were remarkably down‐regulated in the brain, in accordance with the decreased level of plasma cortisol. Moreover, remarkably increased aqp3a and aqp1a1 mRNA levels in the gill were observed, suggesting elevated water intake in the gill. Meanwhile, decreased expression of atp1a1a.1 and the activity of Na+, K+‐ATPase in the gill, which might have resulted from lower plasma cortisol levels, were also present, in consistence with the lesions of histocyte. Moreover, suppressed expression of atp1a1a.4 and the activity of Na+, K+‐ATPase in the kidney were probably resulted from decreased plasma cortisol levels and low expression of avp in the brain.

show abstract

“…E2 is one of endocrinedisrupting estrogen compounds, and was selected as a model target because of its frequent occurrence and its effects on the environment and human health. 22,23 Although the detection of E2 using AuNPs and DNA aptamers has been reported, [24][25][26] non-specic aggregation of AuNPs by possible contaminants has not been considered. KN was also selected as a model contaminant since KN has previously been shown to be the antibiotic showing the strongest non-specic aggregating effect on AuNPs.…”

Section: Introductionmentioning

confidence: 99%