17β-Estradiol Activates Adenosine A2a Receptor After Subarachnoid Hemorrhage

Lin, Chih-Lung; Dumont, Aaron S.; Tsai, Yee-Jean; Huang, Jih-Hui; Chang, Kao-Ping; Kwan, Aij‐Lie; Hong, Yi‐Ren; Howng, Shen-Long

doi:10.1016/j.jss.2008.08.021

Cited by 22 publications

(19 citation statements)

References 31 publications

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“…Due to its short half-life and quick desensitization, other upstream targets are currently being explored [78]. One example is estrogen, which significantly increases A 2A receptor expression [81]. Another agent, ORF4-PE, is a TNF-α-specific antisense oligodeoxynucleotide, and its intracerebral administration after ICH led to decrease in cell death and neurobehavioral deficits [82].…”

Section: Therapeutic Targets and Strategiesmentioning

confidence: 99%

Advances in Neuroprotective Strategies: Potential Therapies for Intracerebral Hemorrhage

et al. 2010

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Intracerebral hemorrhage (ICH) is associated with higher mortality and morbidity than any other form of stroke. However, there currently are no treatments proven to improve outcomes after ICH, and therefore, new effective therapies are urgently needed. Growing insight into ICH pathophysiology has led to the development of neuroprotective strategies that aim to improve the outcome through reduction of secondary pathologic processes. Many neuroprotectants target molecules or pathways involved in hematoma degradation, inflammation or apoptosis, and have demonstrated potential clinical benefits in experimental settings. We extensively reviewed the current understanding of ICH pathophysiology as well as promising experimental neuroprotective agents with particular focus on their mechanisms of action. Continued advances in ICH knowledge, increased understanding of neuroprotective mechanisms, and improvement in the ability to modulate molecular and pathologic events with multitargeting agents will lead to successful clinical trials and bench-to-bedside translation of neuroprotective strategies.

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Section: Therapeutic Targets and Strategiesmentioning

confidence: 99%

Advances in Neuroprotective Strategies: Potential Therapies for Intracerebral Hemorrhage

et al. 2010

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“…Recently, we found that, in neurones, Ngb was pivotal for hormone-induced anti-apoptotic effects against H2O2 toxicity, which may protect brain tissue from oxidative inflammatory injury [54], while E2 increased Ngb expression. (4)E2 has been found to exert antiapoptotic effects through upregulation of adenosine A2a receptor (A2aAR) and extracellular signal-regulated kinases 1 and 2 (ERK1/2) expression [55]. (5)The current in vivo evidence presented by Kao et al [56] implicates Akt signaling pathway in E2-mediated neuroprotection.…”

Section: Estrogenmentioning

confidence: 99%

Drug treatment of cerebral vasospasm after subarachnoid hemorrhage following aneurysms

Liu

Qiu

et al. 2016

Chin Neurosurg Jl

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Cerebral vasospasm (CVS) is a common and severe complication of aneurysmal subarachnoid hemorrhage (aSAH). Despite the improvement in treatment of aSAH, CVS complicating aSAH has remained the main cause of death. CVS begins most often on the third day after the ictal event and reaches the maximum on the 5th-7th postictal days. Several therapeutic modalities have been employed to prevent or reverse CVS. The aim of this review is to summate all the available drug treatment modalities for vasospasm.

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“…This time window may allow for therapeutic intervention with TNF-α modulators, including adenosine receptor antagonists, estrogen, and anti-sense oligodeoxynucleotides such as ORF4-PE. These agents have been shown to decrease cell death, inflammation and neurobehavioral deficits [51][52][53].…”

Section: Tnf-αmentioning

confidence: 99%

Serum biomarkers of spontaneous intracerebral hemorrhage induced secondary brain injury

Brunswick

Hwang

Appelboom

et al. 2012

Journal of the Neurological Sciences

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17β-Estradiol Activates Adenosine A2a Receptor After Subarachnoid Hemorrhage

Cited by 22 publications

References 31 publications

Advances in Neuroprotective Strategies: Potential Therapies for Intracerebral Hemorrhage

Advances in Neuroprotective Strategies: Potential Therapies for Intracerebral Hemorrhage

Drug treatment of cerebral vasospasm after subarachnoid hemorrhage following aneurysms

Serum biomarkers of spontaneous intracerebral hemorrhage induced secondary brain injury

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