17β-Estradiol INCREASES LEISHMANIA MEXICANA KILLING IN MACROPHAGES FROM DBA/2 MICE BY ENHANCING PRODUCTION OF NITRIC OXIDE BUT NOT PRO-INFLAMMATORY CYTOKINES

Lezama-Dávila, Claudio M.; Isaac-Márquez, Angélica Patricia; Barbi, Joseph; Oghumu, Steve; Satoskar, Abhay R.

doi:10.4269/ajtmh.2007.76.1125

Cited by 30 publications

(41 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Infected male mice given intralesion IFN-c exhibited decreased lesion progression compared to control male mice (Satoskar et al 1998). The effects of sex steroid hormones is further evidenced by studies where estrogen treatment of bone marrow-derived macrophages from mice of both sexes demonstrated increased parasite killing and nitric oxide production without an increase in proinflammatory cytokines (Lezama-Davila et al 2007a).…”

Section: Parasitic Infectionsmentioning

confidence: 91%

Gender Specific Differences in the Immune Response to Infection

McClelland

Smith

2011

Arch. Immunol. Ther. Exp.

159

134

View full text Add to dashboard Cite

There are many instances where males and females differ in the susceptibility to infections. The reason for these differences in susceptibility is multifactorial. The primary cause is thought to be due to differences induced by sex hormones and their effects on gene expression as well as the immune system, but may also be due to innate physiological differences between males and females. This review summarizes gender specific differences seen in infections caused by bacteria, fungi, parasites and viruses. Ultimately, gender specific differences appear to be dependent on the microbe causing the infection, as not every infection with a specific microbial type results in increased susceptibility of one gender over the other. This suggests that there is an interaction between gender specific immune differences and the specific immune response to individual microbes.

show abstract

Section: Parasitic Infectionsmentioning

confidence: 91%

Gender Specific Differences in the Immune Response to Infection

McClelland

Smith

2011

Arch. Immunol. Ther. Exp.

159

134

View full text Add to dashboard Cite

show abstract

“…Finally, BMDMs were stained with Giemsa, and the infection rates, blinded by the number of parasites per 100 macrophages, were determined in triplicate. 58 …”

Section: Methodsmentioning

confidence: 99%

A Novel Sterol Isolated from a Plant Used by Mayan Traditional Healers Is Effective in Treatment of Visceral Leishmaniasis Caused by Leishmania donovani

et al. 2015

View full text Add to dashboard Cite

*Corresponding Author: Phone: (614) .edu. Δ Author Contributions: G.G., K.J.P., and D.A. contributed equally to this work Supporting Information The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acsinfecdis.5b00081. Procedures and spectral data for the stepwise synthesis of pentalinonsterol (PDF) NotesThe authors declare no competing financial interest. HHS Public AccessAuthor manuscript ACS Infect Dis. Author manuscript; available in PMC 2017 December 15. Author Manuscript Author Manuscript Author Manuscript Author ManuscriptVisceral leishmaniasis (VL), caused by the protozoan parasite Leishmania donovani, is a global health problem affecting millions of people worldwide. Treatment of VL largely depends on therapeutic drugs such as pentavalent antimonials, amphotericin B, and others, which have major drawbacks due to drug resistance, toxicity, and high cost. In this study, for the first time, we have successfully demonstrated the synthesis and antileishmanial activity of the novel sterol pentalinonsterol (PEN), which occurs naturally in the root of a Mexican medicinal plant, Pentalinon andrieuxii. In the experimental BALB/c mouse model of VL induced by infection with L. donovani, intravenous treatment with liposome-encapsulated PEN (2.5 mg/kg) led to a significant reduction in parasite burden in the liver and spleen. Furthermore, infected mice treated with liposomal PEN showed a strong host-protective TH 1 immune response characterized by IFN-γ production and formation of matured hepatic granulomas. These results indicate that PEN could be developed as a novel drug against VL. Graphical abstractKeywords visceral leishmaniasis; liposome; novel sterol synthesis; antileishmanial Visceral leishmaniasis (VL) is caused by the obligate intracellular parasites Leishmania donovani and Leishmania infantum chagasi via transmission by a sand fly vector. Half a million people are infected with VL, and over 60 000 succumb to the disease annually. The WHO classifies VL as a neglected tropical disease of global health concern. As a potentially life-threatening disease, VL is characterized by parasitic invasion of the blood and reticuloendothelial system, which affects internal organs such as the spleen, liver, and bone marrow. 1 There are currently no licensed vaccines, and chemotherapy is the mainstay to combat the disease. Generally, treatments utilize antileishmanial drugs such as sodium stibogluconate (SSG), pentamidine, amphotericin B (AmpB), liposomal AmpB, miltefosine, and others. 2 These drugs suffer from significant drawbacks, including the need for parenteral routes of administration, poor patient compliance due to long treatment lengths and toxicity, and/or high cost, which limit their use in disease-endemic regions. For more than 50 years, the most common treatment has been antimony, which has potentially cardiotoxic side effects. 3 Additionally, AmpB has been associated with nephrotoxicity. 4 The only promising oral treatment, miltefosine (Impavido, ...

show abstract

“…Both human and mouse monocytes and M/ express estrogen receptors (ERs) [23,25,26]. However, the effect of E2 on M/ depends on the cell, species, and cellular activation state [27], however, the consensus is that E2 usually biases the macrophage to produce non-inflammatory mediators, even during a parasitic infection [28]. The effect of P4 on M/ is less understood, mainly because M/ lack progesterone receptors (PR); however, M/ can still respond to P4 as P4 can act (with lower affinity) through the glucocorticoid receptor (GR) [29].…”

Section: Macrophagesmentioning

confidence: 99%

Immunoregulation of fetal and anti-paternal immune responses

Seavey

Mosmann

2007

Immunol Res

View full text Add to dashboard Cite

Immunological tolerance to the fetus is essential for fetal survival during pregnancy. The semi-allogeneic fetus expresses genes foreign to the mother that can be recognized by maternal T cells. Under times of stress or infection, deleterious immune responses can result in fetal destruction and/or maternal death. Exposure to non-maternal antigens begins as early as insemination and some of the mechanisms required to prevent maternal priming against these antigens are in place before sexual encounter. Continuous and overlapping regulatory mechanisms must cooperate to allow the best chances for fertilization, implantation, and healthy gestation, simultaneously protecting the fetus from maternal immune attack yet making minimal compromises in resistance to infection. Several types of immune cell from both the innate and adaptive arms of the immune system help protect both the mother and fetus during pregnancy. It's the intricate communication and interplay between the immune system and the endocrine system that will ultimately decide the success or fate of the developing fetus.

show abstract

17β-Estradiol INCREASES LEISHMANIA MEXICANA KILLING IN MACROPHAGES FROM DBA/2 MICE BY ENHANCING PRODUCTION OF NITRIC OXIDE BUT NOT PRO-INFLAMMATORY CYTOKINES

Cited by 30 publications

References 12 publications

Gender Specific Differences in the Immune Response to Infection

Gender Specific Differences in the Immune Response to Infection

A Novel Sterol Isolated from a Plant Used by Mayan Traditional Healers Is Effective in Treatment of Visceral Leishmaniasis Caused by Leishmania donovani

Immunoregulation of fetal and anti-paternal immune responses

Contact Info

Product

Resources

About