17β-Estradiol protects female rats from bilateral oophorectomy-induced nonalcoholic fatty liver disease induced by improving linoleic acid metabolism alteration and gut microbiota disturbance

Tian, Ying; Xie, Yuan; Hong, Xinyu; Guo, Zaixin; Yu, Qi

doi:10.1016/j.heliyon.2024.e29013

Cited by 2 publications

(1 citation statement)

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“…Indeed, estrogen plays a crucial role in steatogenesis and lipidomics. Experimental rat models have consistently demonstrated estrogen deficiency results in reduced concentrations of peroxisome proliferator-activated receptor and upregulation of genes mediating endogenous synthesis of cholesterol and free fatty acids culminating in hepatic steatosis[ 17 , 18 ]. Post menopause, as the protective effect of estrogen weans, the risk of developing NAFLD becomes similar to males.…”

Section: Influence Of Sex On Nafld Related Cvd Outcomesmentioning

confidence: 99%

Excess cardiovascular mortality in men with non-alcoholic fatty liver disease: A cause for concern!

Batta,

Hatwal

2024

World J Cardiol

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Non-alcoholic fatty liver disease (NAFLD) has emerged as the commonest cause of chronic liver disease worldwide in recent years. With time, our understanding of NAFLD has evolved from an isolated liver condition to a systemic disease with significant manifestations beyond the liver. Amongst them, cardiovascular diseases (CVDs) are the most important and clinically relevant. Recent research supports a strong independent link between NALFD and CVD beyond the shared risk factors and pathophysiology. Female sex hormones are well known to not only protect against CVD in pre-menopausal females, but also contribute to improved adipose tissue function and preventing its systemic deposition. Recent research highlights the increased risk of major adverse cardiovascular-cerebral events (MACCE) amongst male with NAFLD compared to females. Further, racial variation was observed in MACCE outcomes in NAFLD, with excess mortality in the Native Americans and Asian Pacific Islanders compared to the other races.

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Section: Influence Of Sex On Nafld Related Cvd Outcomesmentioning

confidence: 99%