17β-Estradiol Regulates Glucose Metabolism and Insulin Secretion in Rat Islet β Cells Through GPER and Akt/mTOR/GLUT2 Pathway

Bian, Che; Bai, Bowen; Gao, Qian; Li, Siyi; Yang, Zhao

doi:10.3389/fendo.2019.00531

Cited by 51 publications

(34 citation statements)

References 52 publications

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“…However, little is known about the mechanisms through which androgens are orexigenic [54,76]. ES increase insulin secretion and sensitivity, and suppress gluconeogenesis metabolism [77,78]. Pro-opiomelanocortin (POMC) neurons in the arcuate (ARC) nucleus of the hypothalamus, providing anorexigenic activity, express ERs.…”

Section: Discussionmentioning

confidence: 99%

Soft Drink Consumption in Young Mexican Adults Is Associated with Higher Total Body Fat Percentage in Men but Not in Women

Campos-Ramírez

Ramírez‐Amaya

Olalde-Mendoza

et al. 2020

Foods

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A high consumption of soft drinks (SDs) has been linked with the development of anthropometric and metabolic alterations. We evaluate the association between SD consumption and some anthropometric and metabolic variables. This study is an observational study, using a sample of 394 university students, of which 158 were men (40.1%) and 238 women (59.9%), between 18 and 30 years. An SD intake questionnaire provided the consumption of different SDs. The participants’ weight, height, and waist and hip circumferences were collected. Metabolic biomarkers were analyzed. The average intake of caloric SDs (CSDs) was 1193.6 ± 1534.8 mL/week and 84.5 ± 115.02 mL/week for non-caloric SDs (NCSDs). Sex differences were found in the amount of SD consumption and these statistical differences were driven by those men subjects with a high total body fat percentage (TBF%). In men, correlations were found between the intake of CSDs and the body mass index, waist and hip circumferences, TBF%, and visceral fat percentage. In woman, a correlation was found with glucose and triglycerides. The prediction model revealed that the intake of CSDs predicts TBF% and low-density lipoprotein only in men. A high amount of CSD consumption in men was associated with a high TBF%, and this may be predictive of future development of metabolic abnormalities.

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Section: Discussionmentioning

confidence: 99%

Soft Drink Consumption in Young Mexican Adults Is Associated with Higher Total Body Fat Percentage in Men but Not in Women

Campos-Ramírez

Ramírez‐Amaya

Olalde-Mendoza

et al. 2020

Foods

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“…Two weeks after surgery, the OVX rats were began to receive different treatments. The doses of RJ and Es used in this study were selected according to previous studies (Ahmed, Khalaf, Moselhy, & Safwat, 2014;Bian, Bai, Gao, Li, & Zhao, 2019;Yang et al, 2012). The RJ groups were intragastrically administered RJ (RJL group, 150 mg kg -1 day -1 , RJM group, 300 mg kg -1 day -1 , RJH group, 450 mg kg -1 day -1 ) once per day for 8 weeks.…”

Section: Ovariectomy and Administrationmentioning

confidence: 99%

Royal jelly attenuates nonalcoholic fatty liver disease by inhibiting oxidative stress and regulating the expression of circadian genes in ovariectomized rats

et al. 2020

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Nonalcoholic fatty liver disease (NAFLD) has a high incidence in postmenopausal women and is accompanied by insulin resistance, obesity, and dyslipidemia. Royal jelly (RJ), a natural substance derived from hive, possesses numerous health‐beneficial properties. Here, we evaluated the effects of RJ (150, 300, and 450 mg kg–1 day–1, 8 weeks) on NAFLD in ovariectomized (OVX) rats. Based on the results, RJ ameliorated the degree of anxiety, improved serum lipid profile, and attenuated the hepatic steatosis and liver injury in OVX rats. Furthermore, the protective effects of RJ could be attributed to its antioxidant properties, which enhance the levels of hepatic antioxidant enzymes. The qRT‐PCR results also suggest that RJ improves the disturbances of circadian genes by downregulating their expression, including that of Per1 and Per 2, in the liver of OVX rats. Altogether, our findings suggest that RJ may be a promising agent for the treatment of NAFLD. Practical applications Postmenopausal women are at an increased risk of NAFLD. Currently, there are no licensed therapies for NAFLD. Although hormone replacement therapy (HRT) is reported to inhibit the development of NAFLD, it causes unexpected adverse effects. As HRT is controversial, the use of natural supplements to counteract the detrimental effects of menopause has recently attracted more attention. RJ is a natural product secreted from the hypopharyngeal and mandibular glands of worker bees. The present study illustrates the protective effect of the natural product, RJ, and its underlying mechanisms on NAFLD. This is the first study to assess the effect of RJ on NAFLD under estrogen deficiency. Such findings contribute to the further utilization of RJ, which might serve as a promising therapeutic option and natural food for the treatment of NAFLD.

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“…And the PI3K‐Akt pathway can regulate the expression of GLUT2 in liver tissue to regulate glucose and lipid metabolism. It has been found that the decreased expression of p‐Akt mRNA can also inhibit the expression of GLUT2 gene in patients with type 2 diabetes, and GLUT2 is mainly found in liver, kidney, and pancreas (Bian, Bai, Gao, Li, & Zhao, 2019). Our results showed that AUR can increase the protein levels of GLUT2 in liver.…”

Section: Discussionmentioning

confidence: 99%

Aurantio‐obtusin improves obesity and insulin resistance induced by high‐fat diet in obese mice

Guo

Liao

Qiu³

et al. 2020

Phytotherapy Research

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Aurantio‐obtusin (AUR) is the main bioactive compound among the anthraquinones, from Cassia seed extract. This study was conducted to identify whether AUR could improve obesity and insulin resistance, induced by a high‐fat diet in obese mice. Mice were fed a high‐fat diet for 6 weeks and were then assigned to the high‐fat diet (HFD) control group, the AUR 5 mg/kg group, or the AUR 10 mg/kg group. AUR improves glucose by activating the expression of PI3K, Akt and GLUT4, GLUT2. AUR altered the expression levels of several lipid metabolism‐related and adipokine genes. AUR decreased the mRNA expression of PPAR‐γ, FAS and increased the mRNA expression of PPAR‐α in liver. AUR lowered SREBP‐1c, FAS, SCD‐1, inflammatory cytokines, and increased the expression of PPAR‐γ, PPAR‐α, CPT‐1, and adiponectin in white adipose tissue (WAT). AUR docking with the insulin receptor showed that the residues of the insulin receptor, ectodomain, were the same as those around the emodin. The effect of AUR may be elicited by regulating the activity of the insulin signaling pathway, expression of lipid metabolism‐related genes, and expression of inflammatory cytokine markers to improve adiposity, insulin resistance, and dyslipidemia.

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17β-Estradiol Regulates Glucose Metabolism and Insulin Secretion in Rat Islet β Cells Through GPER and Akt/mTOR/GLUT2 Pathway

Cited by 51 publications

References 52 publications

Soft Drink Consumption in Young Mexican Adults Is Associated with Higher Total Body Fat Percentage in Men but Not in Women

Soft Drink Consumption in Young Mexican Adults Is Associated with Higher Total Body Fat Percentage in Men but Not in Women

Royal jelly attenuates nonalcoholic fatty liver disease by inhibiting oxidative stress and regulating the expression of circadian genes in ovariectomized rats

Aurantio‐obtusin improves obesity and insulin resistance induced by high‐fat diet in obese mice

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