18.2 Model-based analysis of gated cardiac PET images to assess left-ventricular volume and contractile function

Khorsand, Aliasghar; S, Graf; Pirich, C.; Wagner, G; Moertl, Deddo; Frank, Herbert; Kletter, Kurt; Sochor, Heinz; Maurer, Gerald; Porenta, Gerold

doi:10.1016/s1071-3581(01)80854-0

Cited by 12 publications

(24 citation statements)

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“…Assessment of cardiac function by gated FDG PET without the need for other clinical modalities will significantly reduce the time and costs of pre-revascularization work-up. While MRI is considered the reference method for the assessment of LV volumes, most studies compared gated FDG PET with other techniques like gated SPECT, left ventriculography, and 2D echocardiography [75][76][77][78][79][80].…”

Section: Gated Fdg Petmentioning

confidence: 99%

Imaging Techniques in Nuclear Cardiology for the Assessment of Myocardial Viability

Slart

Bax

Veldhuisen

et al. 2005

Int J Cardiovasc Imaging

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The assessment of myocardial viability has become an important aspect of the diagnostic and prognostic work-up of patients with ischemic cardiomyopathy. Although revascularization may be considered in patients with sufficient viable myocardium, patients with predominantly scar tissue should be treated medically. Patients with left ventricular dysfunction who have viable myocardium are the patients at highest risk because of the potential for ischemia but at the same time benefit most from revascularization. It is important to identify viable myocardium in these patients, and radionuclide myocardial scintigraphy is an excellent tool for this. Single-photon emission computed tomography perfusion scintigraphy (SPECT), whether using (201)thallium, (99m)Tc-sestamibi, or (99m)Tc-tetrofosmin, in stress and/or rest protocols, has consistently been shown to be an effective modality for identifying myocardial viability and guiding appropriate management. Metabolic and perfusion imaging with positron emission tomography (PET) radiotracers frequently adds additional information and is a powerful tool for predicting which patients will have an improved outcome from revascularization. New techniques in the nuclear cardiology field, like attenuation corrected SPECT, dual isotope simultaneous acquisition (DISA) SPECT and gated FDG PET are promising and will further improve the detection of myocardial viability. Also the combination of multislice computed tomography scanners with PET opens possibilities of adding coronary calcium scoring and non-invasive coronary angiography to myocardial perfusion imaging and quantification. Evaluation of the clinical role of these creative new possibilities warrants investigation.

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Section: Gated Fdg Petmentioning

confidence: 99%

Imaging Techniques in Nuclear Cardiology for the Assessment of Myocardial Viability

Slart

Bax

Veldhuisen

et al. 2005

Int J Cardiovasc Imaging

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“…This leads to a significant improvement in image quality in humans. Beside that, ECG gating allows the calculation of functional parameters, such as volumes, ejection fraction or wall motion [5,8,16] which provides additional clinical parameters "for free" and was shown to improve diagnostic accuracy [1,11].…”

Section: Introductionmentioning

confidence: 99%

Gated Listmode Acquisition with the QuadHIDAC Animal PET to Image Mouse Hearts

Schäfers

Lang

Stegger

et al. 2006

Zeitschrift für Medizinische Physik

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“…The correlation coefficient for m LV was higher than those found in two previously published studies (r 5 0.82 (7) and 0.7 (9)), with a smaller difference and narrower range (2.3 6 18.1 g in our study as compared with 4 6 32 g in one of those previously published studies (9)). However, both of those studies (7,9) included patients with large defects whereas the current study did not. Areas with low tracer uptake may be more challenging to accurately delineate, explaining the difference in correlation between those two studies and ours.…”

Section: Discussionmentioning

confidence: 67%

“…In addition, electrocardiogram-gated PET can be used to assess LV function, mass, and volume using a variety of PET tracers (6)(7)(8)(9)(10)(11). However, quantification of molecular processes via tracer kinetic analysis requires dynamic scans whereas functional assessments of LV mass (m LV ) and volume require electrocardiogram-gated PET images.…”

mentioning

confidence: 99%

Automatic Extraction of Myocardial Mass and Volume Using Parametric Images from Dynamic Nongated PET

et al. 2016

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Dynamic cardiac PET is used to quantify molecular processes in vivo. However, measurements of left ventricular (LV) mass and volume require electrocardiogram-gated PET data. The aim of this study was to explore the feasibility of measuring LV geometry using nongated dynamic cardiac PET. Methods: Thirty-five patients with aortic-valve stenosis and 10 healthy controls underwent a 27-min 11 C-acetate PET/CT scan and cardiac MRI (CMR). The controls were scanned twice to assess repeatability. Parametric images of uptake rate K 1 and the blood pool were generated from nongated dynamic data. Using software-based structure recognition, the LV wall was automatically segmented from K 1 images to derive functional assessments of LV mass (m LV ) and wall thickness. Endsystolic and end-diastolic volumes were calculated using blood pool images and applied to obtain stroke volume and LV ejection fraction (LVEF). PET measurements were compared with CMR. Results: High, linear correlations were found for LV mass (r 5 0.95), end-systolic volume (r 5 0.93), and end-diastolic volume (r 5 0.90), and slightly lower correlations were found for stroke volume (r 5 0.74), LVEF (r 5 0.81), and thickness (r 5 0.78). Bland-Altman analyses showed significant differences for m LV and thickness only and an overestimation for LVEF at lower values. Intra-and interobserver correlations were greater than 0.95 for all PET measurements. PET repeatability accuracy in the controls was comparable to CMR. Conclusion: LV mass and volume are accurately and automatically generated from dynamic 11 C-acetate PET without electrocardiogram gating. This method can be incorporated in a standard routine without any additional workload and can, in theory, be extended to other PET tracers.Key Words: dynamic PET; stroke volume; myocardial mass; 11 C-acetate; ejection fraction; myocardial wall thickness PET has been used extensively for evaluation of molecular processes of the heart (5). In addition, electrocardiogram-gated PET can be used to assess LV function, mass, and volume using a variety of PET tracers (6-11). However, quantification of molecular processes via tracer kinetic analysis requires dynamic scans whereas functional assessments of LV mass (m LV ) and volume require electrocardiogram-gated PET images. The need for separate reconstructions to assess LV volume and to quantify molecular processes increases workload significantly and has limited the use of combined functional and molecular assessments of the heart. In addition, for some PET tracers such as 15 O-water, no specific uptake is seen in the myocardium, ruling out the use of electrocardiogram-gated reconstructions to assess myocardial function.Recently, automatic parametric imaging became available for 15 O-water (12), and the same methodology can be applied to most other tracers. Parametric images visualize tracer kinetic parameters on the pixel level and are generated during routine quantitative analysis of dynamic PET images. For a single-tissue-compartment model, used for tracers such as 82 Rb...

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18.2 Model-based analysis of gated cardiac PET images to assess left-ventricular volume and contractile function

Cited by 12 publications

References 0 publications

Imaging Techniques in Nuclear Cardiology for the Assessment of Myocardial Viability

Imaging Techniques in Nuclear Cardiology for the Assessment of Myocardial Viability

Gated Listmode Acquisition with the QuadHIDAC Animal PET to Image Mouse Hearts

Automatic Extraction of Myocardial Mass and Volume Using Parametric Images from Dynamic Nongated PET

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