18-F FDG-PET in the staging of lymphocyte-predominant Hodgkin's disease

Ansquer, C.; Hervouet, T.; Devillers, Anne; Guibert, Sophie de; Gastinne, Thomas; Gouill, Steven Le; Garin, Étienne; Moreau, Anne; Kraeber-Bodéré, Françoise; Lamy, Thierry

doi:10.3324/haematol.11661

Cited by 25 publications

(17 citation statements)

References 18 publications

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“…This tool is now the standard for staging and evaluating the treatment response and detecting the aggressiveness of the disease. Recently, it has been proposed to guide the biopsies [5,6] to detect low-grade lymphoma transformation, which is associated with a higher SUV [4,7]. A similar result was reported concerning splenic SUV in low-grade non-Hodgkin’s lymphoma [8].…”

Section: Figsupporting

confidence: 66%

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Failure of <sup>18</sup>Fluorodeoxyglucose Positron Emission Tomography to Detect the High-Grade Transformation of Nodular Lymphocyte Predominant Hodgkin’s Lymphoma

Puyade¹,

Yacoub

Tomowiak³

et al. 2013

Acta Haematol

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Section: Figsupporting

confidence: 66%

“…The suggested cut-off value for the distinction between indolent and high-grade lymphoma, with 100% specificity, was 13, using a receiver operating characteristic (ROC) technique. In a large series of NLPHL, the median SUV was 6.1 (range, 1.2–20.1) [6]. No SUV data were available concerning an aggressive transformation.…”

Section: Figmentioning

confidence: 99%

Failure of <sup>18</sup>Fluorodeoxyglucose Positron Emission Tomography to Detect the High-Grade Transformation of Nodular Lymphocyte Predominant Hodgkin’s Lymphoma

Puyade¹,

Yacoub

Tomowiak³

et al. 2013

Acta Haematol

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“…Glucose uptake and metabolism in the tumor cells may, therefore, be less important in LP cells of NLPHL than in HRS cells of classical HL, as suggested by Hutchings et al, who, in a PET study, found significantly lower standardized glucose uptake values in NLPHL than in classical HL [13]. Nonetheless, a different study showed that staging by PET scan is applicable in NLPHL [30]. We observed GLUT1 expression in the reactive B cell infiltrate in lymphocyte rich HL subtypes (Figure 1f), while the T cell dominated areas were GLUT1-negative.…”

Section: Resultsmentioning

confidence: 99%

GLUT1 expression patterns in different Hodgkin lymphoma subtypes and progressively transformed germinal centers

et al. 2012

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BackgroundIncreased glycolytic activity is a hallmark of cancer, allowing staging and restaging with 18F-fluorodeoxyglucose-positron-emission-tomography (PET). Since interim-PET is an important prognostic tool in Hodgkin lymphoma (HL), the aim of this study was to investigate the expression of proteins involved in the regulation of glucose metabolism in the different HL subtypes and their impact on clinical outcome.MethodsLymph node biopsies from 54 HL cases and reactive lymphoid tissue were stained for glucose transporter 1 (GLUT1), lactate dehydrogenase A (LDHA) and lactate exporter proteins MCT1 and MCT4. In a second series, samples from additional 153 HL cases with available clinical data were stained for GLUT1 and LDHA.ResultsMembrane bound GLUT1 expression was frequently observed in the tumor cells of HL (49% of all cases) but showed a broad variety between the different Hodgkin lymphoma subtypes: Nodular sclerosing HL subtype displayed a membrane bound GLUT1 expression in the Hodgkin-and Reed-Sternberg cells in 56% of the cases. However, membrane bound GLUT1 expression was more rarely observed in tumor cells of lymphocyte rich classical HL subtype (30%) or nodular lymphocyte predominant HL subtype (15%). Interestingly, in both of these lymphocyte rich HL subtypes as well as in progressively transformed germinal centers, reactive B cells displayed strong expression of GLUT1. LDHA, acting downstream of glycolysis, was also expressed in 44% of all cases. We evaluated the prognostic value of different GLUT1 and LDHA expression patterns; however, no significant differences in progression free or overall survival were found between patients exhibiting different GLUT1 or LDHA expression patterns. There was no correlation between GLUT1 expression in HRS cells and PET standard uptake values.ConclusionsIn a large number of cases, HRS cells in classical HL express high levels of GLUT1 and LDHA indicating glycolytic activity in the tumor cells. Although interim-PET is an important prognostic tool, a predictive value of GLUT1 or LDHA staining of the primary diagnostic biopsy could not be demonstrated. However, we observed GLUT1 expression in progressively transformed germinal centers and hyperplastic follicles, explaining false positive results in PET. Therefore, PET findings suggestive of HL relapse should always be confirmed by histology.

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“…Positron emission tomography plays an important role in evaluation of Hodgkin lymphoma, for staging and therapeutic assessment [18, 19]. The PET scan has a prognostic value for evaluation of therapy [20–22].…”

Section: Discussionmentioning

confidence: 99%

Clinical features and treatment outcomes of Hodgkin’s lymphoma in Hong Kong Chinese

Law¹,

Ng²,

Chan³

et al. 2014

aoms

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IntroductionLittle information is available on the outcomes of Hodgkin's lymphoma in Chinese patients. We analyzed the clinical and histopathological characteristics, treatment types, clinical course and treatment outcomes of Hong Kong Chinese patients.Material and methodsPatients with Hodgkin's lymphoma diagnosed from January 1991 to December 2010 were recruited. A retrospective analysis of these patients was performed.ResultsSixty-seven Chinese patients (38 males and 29 females) were identified and the median age was 36 (range 16–80). Nodular sclerosis was the most common histology (54%), followed by mixed cellularity (36%). Twenty-four patients had early favorable, 20 patients had early unfavorable and 23 patients had advanced-stage diseases. The most common presentation was palpable lymph node or mass (85%) followed by fever, weight loss, night sweating and mediastinal mass. Ninety percent of patients received chemotherapy and 40% received radiotherapy as consolidation. Seven patients with stage I lymphoma received radiotherapy alone. ABVD (doxorubicin, bleomycin, vinblastine and dacarbazine) was the most commonly used chemotherapeutic regimen. Following treatment, 87% of patients achieved complete remission. Six patients relapsed after first remission and 3 achieved second remission after re-induction therapy. The 5-year overall survival of the entire cohort was 89% and the freedom from treatment failure (FFTF) at 5 years was 82%. The 5-year overall survival rate for early favorable, early unfavorable and advanced stages was 95.7%, 95.0% and 74.7%, respectively.ConclusionsDespite the relatively low incidence of Hodgkin's lymphoma in Hong Kong Chinese, the treatment outcomes are comparable to Caucasian patients.

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18-F FDG-PET in the staging of lymphocyte-predominant Hodgkin's disease

Cited by 25 publications

References 18 publications

Failure of <sup>18</sup>Fluorodeoxyglucose Positron Emission Tomography to Detect the High-Grade Transformation of Nodular Lymphocyte Predominant Hodgkin’s Lymphoma

Failure of <sup>18</sup>Fluorodeoxyglucose Positron Emission Tomography to Detect the High-Grade Transformation of Nodular Lymphocyte Predominant Hodgkin’s Lymphoma

GLUT1 expression patterns in different Hodgkin lymphoma subtypes and progressively transformed germinal centers

Clinical features and treatment outcomes of Hodgkin’s lymphoma in Hong Kong Chinese

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