182 patients with occupational allergic epoxy contact dermatitis over 22 years

Jolanki, R; Estlander, Tuula; Kanerva, L

doi:10.1034/j.1600-0536.2001.440209-20.x

Cited by 11 publications

(22 citation statements)

References 11 publications

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“…These findings are in agreement with other studies. In a Finnish study, 80% of the epoxy‐allergic patients reacted to epoxy resins of the DGEBA type (epoxy resin MW 340), whereas approximately 20% had negative test results with DGEBA but positive test results with other ERSs (8). Therefore, it is obvious that the baseline series may be insufficient in the event of a negative test result with epoxy resin (MW 340).…”

Section: Discussionmentioning

confidence: 99%

“…It is common to add reactive thinners to epoxy resins in order to reduce the viscosity during mixing. Jolanki et al investigated 182 patients with allergic contact dermatitis following exposure to epoxy resins (8). The authors reported finding allergic reactions to the thinners in 29 patients (16%).…”

Section: Discussionmentioning

confidence: 99%

“…The hardener gives epoxy resins their three‐dimensional final structure. The polyamine hardeners methylenedianiline, isophoronediamine and diethylenetriamine are also known to be strongly sensitizing chemicals (4, 8). In addition, hardeners are often responsible for skin irritation because of their caustic nature, which may facilitate sensitization with the epoxy resin itself.…”

Section: Discussionmentioning

confidence: 99%

“…In previous studies, skin reactions appearing within a short time of airborne exposure to ERSs have been interpreted as type IV allergy caused by reactive volatile thinners and hardeners. Cases of acute contact urticaria (IgE‐mediated, type I allergy), after contact with certain highly sensitizing hardeners such as methylhexahydrophthalic anhydride, hexahydrophthalic anhydride, and DGEBA epoxy resin, have also been reported (8, 10).…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Epoxy pipe relining—an emerging contact allergy risk for workers

Berglind¹,

Lind²,

Lidén³

2012

Contact Dermatitis

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Epoxy pipe relining—an emerging contact allergy risk for workers

Berglind¹,

Lind²,

Lidén³

2012

Contact Dermatitis

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“…According to reports from occupational health clinic populations [62,66,102], in a former study one of the authors (H.D.) found epoxy resin sensitization in the group of patients with suspicion of an OSD [23].…”

Section: Epoxy Resinmentioning

confidence: 99%

Occupational relevance of positive standard patch-test results in employed persons with an initial report of an occupational skin disease

Dickel

Kuß

Schmidt³

et al. 2002

International Archives of Occupational and Environmental Health

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Reduced Sensitizing Capacity of Epoxy Resin Systems: A Structure−Activity Relationship Study

Niklasson

Broo

Jonsson

et al. 2009

Chem. Res. Toxicol.

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Epoxy resins can be prepared from numerous chemical compositions. Until recently, alternatives to epoxy resins based on diglycidyl ethers of bisphenol A (DGEBA) or bisphenol F (DGEBF) monomers have not received commercial interest, but are presently doing so, as epoxy resins with various properties are desired. Epoxy resin systems are known to cause allergic contact dermatitis because of contents of uncured monomers, reactive diluents, and hardeners. Reactive diluents, for example, glycidyl ethers, which also contain epoxide moieties, are added to reduce viscosity and improve polymerization. We have investigated the contact allergenic properties of a series of six analogues to phenyl glycidyl ether (PGE), all with similar basic structures but with varying carbon chain lengths and degrees of saturation. The chemical reactivity of the compounds in the test series toward the hexapeptide H-Pro-His-Cys-Lys-Arg-Met-OH was investigated. All epoxides were shown to bind covalently to both cysteine and proline residues. The percent depletion of nonreacted peptide was also studied resulting in 88% depletion when using PGE and 46% when using butyl glycidyl ether (5) at the same time point, thus revealing a large difference between the fastest and the slowest reacting epoxide. The skin sensitization potencies of the epoxides using the murine local lymph node assay (LLNA) were evaluated in relation to the observed physicochemical and reactivity properties. To enable determination of statistical significance between structurally closely related compounds, a nonpooled LLNA was performed. It was found that the compounds investigated ranged from strong to weak sensitizers, congruent with the reactivity data, indicating that even small changes in chemical structure result in significant differences in sensitizing capacity.

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182 patients with occupational allergic epoxy contact dermatitis over 22 years

Cited by 11 publications

References 11 publications

Epoxy pipe relining—an emerging contact allergy risk for workers

Epoxy pipe relining—an emerging contact allergy risk for workers

Occupational relevance of positive standard patch-test results in employed persons with an initial report of an occupational skin disease

Reduced Sensitizing Capacity of Epoxy Resin Systems: A Structure−Activity Relationship Study

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