186. Attitudes Toward HIV Pre-Exposure Prophylaxis In A Sample of Adolescents And Young Adults Attending A U.S. Urban Primary Care Clinic

Garrett, William S.; Wheeler, Noah J.; Oliva, Miles; Reed, Christopher Robert; Conley, James; Alvarenga, Aubrey; Marcell, Arik V.; Fields, Errol L.; Arrington‐Sanders, Renata

doi:10.1016/j.jadohealth.2018.10.203

Cited by 4 publications

(10 citation statements)

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“…PrEP awareness among Black and Latinx adolescents in this study is similar to other studies with community samples of Black and Latinx young adults [ 12 , 22 , 23 ]. Our finding that PrEP awareness is associated with prior HIV testing may be related to higher risk perception and greater exposure to PrEP promotion messages for adolescents who have received an HIV test.…”

Section: Discussionsupporting

confidence: 89%

“…While a number of studies investigate factors associated with PrEP awareness and interest in young adults, limited attention has been given to sexually active racial/ethnic minority adolescents. PrEP awareness among Black and Latinx adolescents in this study is similar to other studies with community samples of Black and Latinx young adults [12,22,23]. Our finding that PrEP awareness is associated with prior HIV testing may be related to higher risk perception and greater exposure to PrEP promotion messages for adolescents who have received an HIV test.…”

Section: Plos Onesupporting

confidence: 87%

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Awareness of and willingness to use PrEP among Black and Latinx adolescents residing in higher prevalence areas in the United States

Taggart

Pina

et al. 2020

PLoS ONE

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This mixed-methods study examined awareness of and willingness to use pre-exposure prophylaxis (PrEP) among sexually active Black and Latinx adolescents (13-17 years) residing in five cities in the United States with some of the highest burden of HIV. Data are from adolescents who participated in a cross-sectional survey (n = 208) and one-on-one interviews and focus groups (n = 26) conducted from September 2017-August 2019. Approximately 50% of the sample were recruited through community efforts, and the other half through a panel. Logistic regression with covariates including sexual orientation, relationship status, socioeconomic status, and race/ethnicity were used to assess factors associated with PrEP awareness and willingness. For the qualitative data, thematic analysis was used to develop a codebook of a-priori and inductive codes while analytic memos were written to identify key themes. PrEP awareness was reported by 38% of the sample and was associated with Black race (AOR = 0.49; 95% CI = 0.27, 0.90) and prior HIV testing (AOR = 3.89, 95% CI = 1.25, 12.08). PrEP willingness (defined as "definitely would use PrEP") was reported by 22% of the sample and was associated with higher age, more education, having had condomless sex in the past 6 months (AOR = 0.23; 95% CI = 0.10, 0.56), perceived likelihood of acquiring HIV (AOR = 3.59; 95% CI = 1.06, 12.21), and PrEP awareness (AOR = 0.41; 95% CI = 0.19, 0.89). Qualitative data showed that misconceptions about PrEP persist and PrEP stigma, fear of being punished, provider attitudes and recommendations, and empowerment were related to adolescents' willingness to use PrEP. Study findings reveal important strategies for improving PrEP delivery and scale-up to Black and Latinx adolescents. These strategies include using sociodemographic and health behavior data to target adolescents who may be more or less willing to use PrEP, improving provider communication about PrEP, and creating culturally and developmentally appropriate PrEP education materials that address common misconceptions held by adolescents.

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Section: Discussionsupporting

confidence: 89%

Section: Plos Onesupporting

confidence: 87%

Awareness of and willingness to use PrEP among Black and Latinx adolescents residing in higher prevalence areas in the United States

Taggart

Pina

et al. 2020

PLoS ONE

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“…The belief held by a few of our participants that they did not need to take PrEP because they were not at risk or had other HIV prevention methods, corroborates the findings of other studies which show that individuals exhibiting optimal beliefs in susceptibility are not likely to accept any recommended health action [25,40]. Therefore, HIV prevention interventions need to be explicit as to what might cause HIV risk if these interventions are to benefit the targeted groups of key or high risk populations [41].…”

Section: Plos Onesupporting

confidence: 89%

“…influence from other people as well as the lingering doubts regarding the drug's efficacy negatively influenced uptake. In addition, the limited understanding of PrEP as well as the fears/ concerns exhibited by our study participants prevented some of them from taking up the intervention much as they considered it beneficial, as documented in other studies [25]. Research has shown how anticipation of negative effects can influence intervention acceptance, uptake, and adherence [23,26,27].…”

Section: Plos Onementioning

confidence: 78%

Assessing acceptability of pre-exposure prophylaxis (PrEP) among participants in an HIV vaccine preparedness study in southwestern Uganda

Nakamanya

Kawuma²,

Kibuuka³

et al. 2022

PLoS ONE

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Background Daily oral pre-exposure prophylaxis (PrEP) use is highly effective against HIV infection. However, the uptake of PrEP among individuals at high-risk of HIV acquisition in sub-Saharan Africa varies because of availability and acceptability. We assessed the acceptability of PrEP among participants in a prospective HIV vaccine preparedness study in Masaka, southwestern Uganda. Methods From November 2018 to August 2019, 20 participants (10 female) were purposively selected for in-depth interviews (IDIs) at 3 and 9 months’ post-enrolment in the vaccine preparedness study. Four focus group discussions (FGD) (two among men) were conducted with 29 individuals categorized as: younger (18–24 years) men, younger (18–24 years) women, older (≥30 years) men, and older (≥30 years) women. Apart from IDI specific questions on recent life history including work experience, relationship history and places lived, topics for IDIs and FGDs included knowledge of HIV, perceptions of HIV risk (including own risk), knowledge of and use of PrEP. The Theoretical Framework of Acceptability was used to structure a thematic framework approach for data analysis. Results Participants understood that PrEP was an oral pill taken daily by HIV negative individuals to prevent acquisition of HIV. Overall, interest in and acceptability of PrEP was high, more than half expressed positivity towards PrEP but were not ready to initiate taking it citing the burden of daily oral pill taking, related side effects, stigma and distrust of PrEP. Fourteen participants (from IDI and FGD) initiated PrEP, although some (one FGD and two IDI participants) stopped taking it due to side effects or perceived reduced risk. Conclusion We observed a keen interest in PrEP initiation among our study participants. However, a limited understanding of PrEP and associated concerns impeded uptake and sustained use. Hence, interventions are needed to address end-user challenges to increase uptake and support adherence.

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“…[22] Studies have shown that self-perceived low risk of HIV infection is a major factor in the low uptake of PrEP. [23] We found that residence was significantly associated with PrEP uptake with individuals who lived in nonfishing communities having higher odds of uptake. Compared to fishing communities, nonfishing communities in Uganda generally have better access to healthcare services.…”

Section: Discussionmentioning

confidence: 63%

Predictors of oral pre-exposure prophylaxis (PrEP) uptake among individuals in a HIV vaccine preparedness cohort in Masaka, Uganda

et al. 2021

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Oral pre-exposure prophylaxis (PrEP) significantly reduces human immunodeficiency virus (HIV) acquisition risk. However, data on predictors of PrEP uptake in sub-Saharan Africa are limited. We assessed predictors of PrEP uptake among HIV-uninfected high risk individuals enrolled in a HIV vaccine preparedness study in Masaka, Uganda.Between July 2018 and October 2020, we recruited adults (18–40 years) from sex work hotspots along the trans-African highway and Lake Victoria fishing communities. We collected baseline data on socio-demographics and PrEP awareness, and provided HIV counselling and testing, information on PrEP, and PrEP referrals at quarterly visits. Urine pregnancy tests (women) and data collection on sexual risk behaviour and PrEP uptake were performed every 6 months. We analysed PrEP uptake among participants who had completed 6 months of follow-up.Of the 588 cohort participants, 362 (62%) were included in this analysis. Of these, 176 (49%) were female, 181 (50%) were aged ≤24 years, 104 (29%) worked in sex work hotspots, 74 (20%) were fisher folk. Only 75 (21%) participants initiated PrEP. Predictors of PrEP uptake included having ≥6 sex partners (adjusted odds ratio [aOR] = 2.29; 95% confidence interval [CI] 1.26–4.17), engaging in transactional sex (aOR = 2.23; 95% CI 0.95–5.20), and residence in a nonfishing community (aOR = 2.40; 95% CI 1.14–5.08). The commonest reasons for not starting PrEP were pill burden (38%) and needing more time to decide (27%).PrEP uptake was low and associated with HIV risk indicators in this cohort. Interventions are needed to improve access to PrEP especially in fishing communities.

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186. Attitudes Toward HIV Pre-Exposure Prophylaxis In A Sample of Adolescents And Young Adults Attending A U.S. Urban Primary Care Clinic

Cited by 4 publications

References 0 publications

Awareness of and willingness to use PrEP among Black and Latinx adolescents residing in higher prevalence areas in the United States

Awareness of and willingness to use PrEP among Black and Latinx adolescents residing in higher prevalence areas in the United States

Assessing acceptability of pre-exposure prophylaxis (PrEP) among participants in an HIV vaccine preparedness study in southwestern Uganda

Predictors of oral pre-exposure prophylaxis (PrEP) uptake among individuals in a HIV vaccine preparedness cohort in Masaka, Uganda

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