186: Delayed Functional Recovery in Diabetic Rats after Simulated Childbirth

Kim, Ja-Hong; Moore, Courtenay; Saffore, Lateef; Bena, James; Damaser, Margot S.; Daneshgari, Firouz

doi:10.1016/s0022-5347(18)32453-4

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Using a female diabetic rat model to study stress urinary incontinence (SUI), Daneshgari noted a delayed recovery of sphincteric function after simulated childbirth among rats with experimentally induced diabetes compared with age-matched controls, suggesting that, even acutely, hyperglycemia can impact on urethral function [8]. These findings suggest that normal reparative mechanisms to prevent stress leakage may be diminished in diabetics.…”

Section: Physiology Of Bladder Dysfunction In Diabetesmentioning

confidence: 99%

Lower Urinary Tract Dysfunction in the Diabetic Elderly

Lemack¹

2007

Aging Health

View full text Add to dashboard Cite

Elderly patients with diabetes appear to be particularly susceptible to urological complications. Diabetes impacts the urological quality of life as bothersome urinary symptoms (including incontinence) are clearly associated with the development and progression of diabetes. When recognized early, many symptoms can be treated through a combination of behavioral and pharmacological management. Without attention to the early signs of urinary symptoms in elderly patients, significant urological dysfunction may occur, leading to morbidity and often-preventable symptomatic deterioration.It has been estimated that diabetes affects over 246 million people worldwide, with the prevalence clearly on the rise over the last several decades [101]. Indeed, the prevalence of this condition may double by the year 2030. Among those hardest hit by this condition are the elderly, in whom systemic manifestations, such as retinopathy, peripheral neuropathy and nephropathy can result in serious and costly health consequences. The WHO has estimated that in 2007, US$232 billion will be spent worldwide to evaluate and treat diabetes, and that 6% of all deaths are attributable to complications associated with diabetes.Bladder dysfunction in the setting of diabetes, often referred to as diabetic cystopathy, is perhaps more poorly defined and certainly less well recognized that some of the other manifestations of diabetes [1]. Still, it has been estimated that up to 50% of diabetic patients will experience complications related to neurogenic bladder dysfunction resulting from diabetes [2]. Clinical manifestations may start out innocuous, an occasional urinary tract infection or mild urinary frequency, but ultimately can become quite severe. Debilitating urinary incontinence, acute and chronic pyelonephritis, and even renal failure related to a progressive impairment in detrusor function have all been described in diabetic patients. As with other sequelae of diabetes, the early clinical signs of neurogenic bladder dysfunction may be difficult to recognize, often leading to late diagnosis and a missed opportunity for early prevention of serious complications.In the current review, we will first focus on the physiological basis for lower urinary tract dysfunction in diabetic patients and describe the clinical manifestations of that dysfunction. The tools utilized to evaluate bladder dysfunction are discussed, with the typical findings of diabetic patients highlighted. Last, we offer recommendations for recognizing and treating bladder dysfunction related to diabetes, with the goal of minimizing urological complications.

show abstract

Section: Physiology Of Bladder Dysfunction In Diabetesmentioning

confidence: 99%